Results 91 to 100 of about 6,058 (200)
BicD and MAP7 Collaborate to Activate Homodimeric Drosophila Kinesin‐1 by Complementary Mechanisms
Traffic, Volume 26, Issue 4-6, April‐June 2025.Kinesin‐1 is auto‐inhibited and binds microtubules weakly. Binding of kinesin‐1 to the adaptor protein BicD enhances processive motion, while the microtubule‐associated protein MAP7 recruits more kinesin to the microtubule and enhances run length.
M. Yusuf Ali +4 more
wiley +1 more source
Dynamic regulation of dynein localization revealed by small molecule inhibitors of ubiquitination enzymes [PDF]
, 2019 Cytoplasmic dynein is a minus-end-directed microtubule-based motor that acts at diverse subcellular sites. During mitosis, dynein localizes simultaneously to the mitotic spindle, spindle poles, kinetochores and the cell cortex.
Cheeseman, Iain M, Monda, Julie Kathryn
core +1 more source
At the nucleus of cancer: how the nuclear envelope controls tumor progression
MedComm, Volume 6, Issue 2, February 2025.The review is focused on exploring novel intriguing perspectives on the role of the nuclear envelope in tumor progression. Alterations of nuclear envelope proteins result in the dysregulation of cellular pathways and promote tumorigenesis, highlighting that complex regulatory mechanisms lie behind the alterations in nuclear shape in cancer, thus ...
Francesca Paganelli +6 more
wiley +1 more source
Nitrogen Isotopic Fractionation in Interstellar Ammonia [PDF]
, 2010 Using the Green Bank Telescope (GBT), we have obtained accurate measurements of the $^{14}$N/$^{15}$N isotopic ratio in ammonia in two nearby cold, dense molecular clouds, Barnard~1 and NGC 1333. The $^{14}$N/$^{15}$N ratio in Barnard~1, $334 \pm 50$ (3$\
Abbas +7 more
core +3 more sources
Journal of Cell Biology, 2012 ![Figure][1] Endosomes (green) move in normal fungi (top) but stay put if Lis1 is absent (bottom). Egan et al. clarify the role of the dynein co-factor Lis1 in cargo transport. The molecular motor dynein ferries cargoes toward the minus ends of microtubules, typically toward the nucleus.
openaire +2 more sources
14‐3‐3ε conditional knockout mice exhibit defects in the development of the epidermis
FEBS Letters, Volume 598, Issue 24, Page 3005-3020, December 2024.A knockout of 14‐3‐3ε in the basal layer of the epidermis in mice leads to a decrease in proliferation and the thickness of the epidermis and decreased expression of differentiation markers. The knockout cells also show centrosome amplification, suggesting that centrosome amplification leads to decreased proliferation and subsequent thinning of the ...
Sarika Tilwani +2 more
wiley +1 more source
Dual pathway spindle assembly increases both the speed and the fidelity of mitosis [PDF]
, 2011 Roughly half of all animal somatic cell spindles assemble by the classical prophase pathway, in which the centrosomes separate ahead of nuclear envelope breakdown (NEBD).
Cross, R. A. +2 more
core +2 more sources
Structural Consequence of Non-Synonymous Single-Nucleotide Variants in the N-Terminal Domain of LIS1 [PDF]
, 2022 Ho Jin Choi +8 more
openalex +1 more source
Linking secretion and cytoskeleton in immunity– a case for Arabidopsis TGNap1
BioEssays, Volume 46, Issue 11, November 2024.Intracellular trafficking, particularly in defense, depends on F‐actin and microtubules (MTs). Cytoskeleton‐Organelle Bridging Proteins (COBPs) link vesicles to these structures, ensuring directional transport. While the specifics of this association are unclear, TGNap1 has been identified as a crucial MT‐binding COBP for defense trafficking ...
Deepak D. Bhandari, Federica Brandizzi
wiley +1 more source
Scientific ReportsSpermatogenesis involves complex dynamic mechanisms. Dynein-1 is a key carrier in cellular cargo transport, participating in nuclear deformation and acrosome formation during spermatogenesis.
Le Chang +6 more
doaj +1 more source