Results 41 to 50 of about 6,058 (200)
Teaming up: from motors to people. [PDF]
, 2013 When I reflect on how I became a cell biologist and why I love being one today, one thing that comes to mind is the many terrific collaborations I have had.
Reck-Peterson, Samara L
core +1 more source
eLife, 2020 Heterozygous loss of human PAFAH1B1 (coding for LIS1) results in the disruption of neurogenesis and neuronal migration via dysregulation of microtubule (MT) stability and dynein motor function/localization that alters mitotic spindle orientation ...
Hyang Mi Moon +3 more
doaj +1 more source
Global developmental gene expression and pathway analysis of normal brain development and mouse models of human neuronal migration defects. [PDF]
PLoS Genetics, 2011 Heterozygous LIS1 mutations are the most common cause of human lissencephaly, a human neuronal migration defect, and DCX mutations are the most common cause of X-linked lissencephaly.
Tiziano Pramparo +7 more
doaj +1 more source
Functional coupling of microtubules to membranes - implications for membrane structure and dynamics [PDF]
, 2012 The microtubule network dictates much of the spatial patterning of the cytoplasm, and the coupling of microtubules to membranes controls the structure and positioning of organelles and directs membrane trafficking between them.
Stephens, David J
core +2 more sources
LIS1 and Spindle Orientation in Neuroepithelial Cells [PDF]
Cell Stem Cell, 2008 Asymmetric stem cell division is thought to require precise orientation of the mitotic spindle. However, a recent study in Cell (Yingling et al., 2008) analyzes the role of LIS1 in the developing mouse brain and shows that spindle orientation is more important during early, symmetric progenitor cell divisions than for later asymmetric divisions.
Schwamborn, Jens C. +1 more
openaire +2 more sources
Cell Reports, 2018 Summary: Intracellular transport of membranous organelles and protein complexes to various destinations is fundamental to signaling transduction and cellular function.
Liansheng Liu +7 more
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Both doublecortin and doublecortin-like kinase play a role in cortical interneuron migration [PDF]
, 2007 Type I lissencephaly, a genetic disease characterized by disorganized cortical layers and gyral abnormalities, is associated with severe cognitive impairment and epilepsy.
Antypa, M +5 more
core +1 more source
iScience, 2022 Summary: In the axon terminal, microtubule stability is decreased relative to the axon shaft. The dynamic microtubule plus ends found in the axon terminal have many functions, including serving as a docking site for the Cytoplasmic dynein motor. Here, we
Dane Kawano +6 more
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Reconstitution of dynein transport to the microtubule plus end by kinesin [PDF]
, 2014 Cytoplasmic dynein powers intracellular movement of cargo toward the microtubule minus end. The first step in a variety of dynein transport events is the targeting of dynein to the dynamic microtubule plus end, but the molecular mechanism underlying this
Goodman, Brian S +2 more
core +4 more sources
Developmental downregulation of LIS1 expression limits axonal extension and allows axon pruning
Biology Open, 2017 The robust axonal growth and regenerative capacities of young neurons decrease substantially with age. This developmental downregulation of axonal growth may facilitate axonal pruning and neural circuit formation but limits functional recovery following ...
Kanako Kumamoto +5 more
doaj +1 more source