Results 41 to 50 of about 8,390 (226)
Intracellular Logistics Coordinated by LIS1 and Lissencephaly
Seibutsu Butsuri, 2011 Masami Yamada
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An Essential Postdevelopmental Role for Lis1 in Mice [PDF]
eneuro, 2018 LIS1mutations cause lissencephaly (LIS), a severe developmental brain malformation. Much less is known about its role in the mature nervous system. LIS1 regulates the microtubule motor cytoplasmic dynein 1 (dynein), and as LIS1 and dynein are both expressed in the adult nervous system, Lis1 could potentially regulate dynein-dependent processes such as ...
Timothy J. Hines +6 more
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Frontiers in Cell and Developmental Biology, 2021 LIS1 is one of the principal genes related to Type I lissencephaly, a severe human brain malformation characterized by an abnormal neuronal migration in the cortex during embryonic development.
Raquel Garcia-Lopez +5 more
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LIS1 and Spindle Orientation in Neuroepithelial Cells [PDF]
Cell Stem Cell, 2008 Asymmetric stem cell division is thought to require precise orientation of the mitotic spindle. However, a recent study in Cell (Yingling et al., 2008) analyzes the role of LIS1 in the developing mouse brain and shows that spindle orientation is more important during early, symmetric progenitor cell divisions than for later asymmetric divisions.
Jens Christian Schwamborn +1 more
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CNV and nervous system diseases - what's new? [PDF]
, 2008 Several new genomic disorders caused by copy number variation (CNV) of genes whose dosage is critical for the physiological function of the nervous system have been recently identified.
Gu, W., Lupski, J. R.
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Inhibition of PP2A by LIS1 increases HIV-1 gene expression
Retrovirology, 2006 Background Lissencephaly is a severe brain malformation in part caused by mutations in the LIS1 gene. LIS1 interacts with microtubule-associated proteins, and enhances transport of microtubule fragments.
Turner Willie +3 more
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Regulation of Cytoplasmic Dynein ATPase by Lis1 [PDF]
The Journal of Neuroscience, 2006 Mutations in Lis1 cause classical lissencephaly, a developmental brain abnormality characterized by defects in neuronal positioning. Over the last decade, a clear link has been forged between Lis1 and the microtubule motor cytoplasmic dynein. Substantial evidence indicates that Lis1 functions in a highly conserved pathway with dynein to regulate ...
Mesngon, Mariano T. +8 more
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New insights into the mechanism of dynein motor regulation by lissencephaly-1
eLife, 2020 Lissencephaly (‘smooth brain’) is a severe brain disease associated with numerous symptoms, including cognitive impairment, and shortened lifespan. The main causative gene of this disease – lissencephaly-1 (LIS1) – has been a focus of intense scrutiny ...
Steven M Markus +2 more
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LIS1 regulates osteoclast formation and function through its interactions with dynein/dynactin and Plekhm1. [PDF]
PLoS ONE, 2011 Microtubule organization and lysosomal secretion are both critical for the activation and function of osteoclasts, highly specialized polykaryons that are responsible for bone resorption and skeletal homeostasis.
Shiqiao Ye +9 more
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Dynein Regulators Are Important for Ecotropic Murine Leukemia Virus Infection [PDF]
, 2016 Indexación: Web of Science.During the early steps of infection, retroviruses must direct the movement of the viral genome into the nucleus to complete their replication cycle.
Arriagada, Gloria +4 more
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