Results 51 to 60 of about 6,058 (200)

DISC1 is needed for the organization of cellular components at the immunological synapse. [PDF]

, 2019
T-cells carry out their immune functions through receptor-based recognition and adhesion to target cells. The cell-cell junction that is created from this connection is known as the immunological synapse (IS); a cellular structure composed of organized ...
Ramakrishnan, Adarsh
core   +1 more source

Targeted mutagenesis of Lis1 disrupts cortical development and LIS1 homodimerization [PDF]

Proceedings of the National Academy of Sciences, 2001
Lissencephaly is a severe brain malformation in humans. To study the function of the gene mutated in lissencephaly ( LIS1 ), we deleted the first coding exon from the mouse Lis1 gene. The deletion resulted in a shorter protein (sLIS1) that initiates from the second methionine, a unique ...
Cahana, A., Escamez, T., Nowakowski, R., Hayes, N., Giacobini, M., Holst, A., Shmueli, O., Sapir, T., McConnell, S., Wurst, W., Martinez, S., Reiner, O.   +11 more
openaire   +3 more sources

Responsible Genes for Neuronal Migration in the Chromosome 17p13.3: Beyond Pafah1b1(Lis1), Crk and Ywhae(14-3-3ε)

Brain Sciences, 2021
The 17p13.3 chromosome region is often deleted or duplicated in humans, resulting in severe neurodevelopmental disorders such as Miller–Dieker syndrome (MDS) and 17p13.3 duplication syndrome.
Xiaonan Liu, Sarah A. Bennison, Lozen Robinson, Kazuhito Toyo-oka   +3 more
doaj   +1 more source

Locomotor hyperactivity in 14-3-3Zeta KO mice is associated with dopamine transporter dysfunction [PDF]

, 2013
Dopamine (DA) neurotransmission requires a complex series of enzymatic reactions that are tightly linked to catecholamine exocytosis and receptor interactions on pre- and postsynaptic neurons.
A Abi-Dargham, A Aitken, A Breier, A Vina-Vilaseca, AA Williams, AH Wong, B Giros, B Giros, BL Summers, BT Baune, C Itagaki, CA Tamminga, D Berg, D Sulzer, DL Levy, FA Middleton, H Fu, H Jaaro-Peled, H Khoshbouei, H Koike, HC Baxter, J Sun, J Wang, JA English, JA English, JA Lieberman, JA Lieberman, JH Son, JM van Rossum, K Toska, K Toyo-oka, K Toyo-Oka, KL Holton, M Laruelle, M Laruelle, M Miranda, M Rosner, M van den Buuse, M van den Buuse, MS Samuel, O Halskau Jr., P Coyle, PC Hart, PS Cheah, S Leucht, S Sivagnanasundaram, S Sivagnanasundaram, SG Amara, SR Jones, T Ichimura, T Ichimura, WC Drevets, WT Carpenter, Y Jia   +53 more
core   +2 more sources

Lissencephaly-1 dependent axonal retrograde transport of L1-type CAM Neuroglian in the adult drosophila central nervous system. [PDF]

PLoS ONE, 2017
Here, we established the Drosophila Giant Fiber neurons (GF) as a novel model to study axonal trafficking of L1-type Cell Adhesion Molecules (CAM) Neuroglian (Nrg) in the adult CNS using live imaging.
Sirisha R Kudumala, Tyrone Penserga, Jana Börner, Olesya Slipchuk, Priyanka Kakad, LaTasha H Lee, Aater Qureshi, Jan Pielage, Tanja A Godenschwege   +8 more
doaj   +1 more source

A realistic assessment of methods for extracting gene/protein interactions from free text [PDF]

, 2009
Background: The automated extraction of gene and/or protein interactions from the literature is one of the most important targets of biomedical text mining research.
A Moschitti, AB Clegg, Adrian J Shepherd, AM Cohen, Andrew B Clegg, AS Yeh, B Settles, C Nédellec, D Rebholz-Schuhmann, H Jose, HL Johnson, J Ding, J Fluck, JD Kim, JD Kim, K Franzén, K Fundel, K Sagae, L Hunter, M Krallinger, N Domedel-Puig, R Bunescu, R Hoffmann, R Kabiljo, R Kabiljo, R Leaman, R Sætre, Renata Kabiljo, S Pyysalo, S Pyysalo, S Pyysalo, T Hara, WA Baumgartner   +32 more
core   +4 more sources

Special Values of Generalized Polylogarithms

, 2007
We study values of generalized polylogarithms at various points and relationships among them. Polylogarithms of small weight at the points 1/2 and -1 are completely investigated. We formulate a conjecture about the structure of the linear space generated
D Bowman, EA Ulanskii, HN Minh, HRP Ferguson, J Sondow, JAM Vermaseren, JM Borwein, L Lewin, M Abramowitz, ME Hoffman, N Nielsen, P Deligne, P Flajolet, S. A. Zlobin, SA Zlobin, T Terasoma, VN Sorokin, WW Zudilin   +17 more
core   +1 more source

Assessment of Molecular Cytogenetic Methods for the Detection of Chromosomal Abnormalities [PDF]

, 2006
Some marker chromosomes and chromosome rearrangements are difficult to identify using G-bands by Giemsa staining after trypsin treatment (G-banding) alone.
Maruyama, Hidehiko, Morishima, Tsuneo, Ninomiya, Shinsuke, Shinozuka, Masako, Une, Tomoka, Yokoyama, Yuji   +5 more
core   +1 more source

Mechanism Of Lis1 In Promoting Perineural Invasion Of Hnscc

International Dental Journal
Aim or purpose: This study investigates the role of LIS1 in promoting perineural invasion (PNI) and metastasis in HNSCC. Materials and methods: LIS1 expression was assessed in HNSCC using TCGA datasets. To evaluate the correlation between LIS1 and PNI in
Ao Dai, Lu Gao, Xiang yu Zhu
doaj   +1 more source

Interplay of LIS1 and MeCP2: Interactions and Implications With the Neurodevelopmental Disorders Lissencephaly and Rett Syndrome

Frontiers in Cellular Neuroscience, 2019
LIS1 is the main causative gene for lissencephaly, while MeCP2 is the main causative gene for Rett syndrome, both of which are neurodevelopmental diseases.
Liraz Keidar, Gabi Gerlitz, Aditya Kshirsagar, Michael Tsoory, Tsviya Olender, Xing Wang, Ying Yang, Yu-Sheng Chen, Yun-Gui Yang, Irina Voineagu, Orly Reiner   +10 more
doaj   +1 more source