Results 51 to 60 of about 8,390 (226)

Lis1 regulates dynein by sterically blocking its mechanochemical cycle

eLife, 2014
Regulation of cytoplasmic dynein's motor activity is essential for diverse eukaryotic functions, including cell division, intracellular transport, and brain development.
Katerina Toropova, Sirui Zou, Anthony J Roberts, William B Redwine, Brian S Goodman, Samara L Reck-Peterson, Andres E Leschziner   +6 more
doaj   +1 more source

Molecular and Genetic Determinants of Glioma Cell Invasion. [PDF]

, 2017
A diffusely invasive nature is a major obstacle in treating a malignant brain tumor, "diffuse glioma", which prevents neurooncologists from surgically removing the tumor cells even in combination with chemotherapy and radiation.
Kato, Yoichiro, Masui, Kenta, Mischel, Paul S, Sawada, Tatsuo, Shibata, Noriyuki   +4 more
core   +2 more sources

Molecular mechanism of dynein-dynactin complex assembly by LIS1. [PDF]

Science
Cytoplasmic dynein is a microtubule motor vital for cellular organization and division. It functions as a ~4-megadalton complex containing its cofactor dynactin and a cargo-specific coiled-coil adaptor. However, how dynein and dynactin recognize diverse adaptors, how they interact with each other during complex formation, and the role of critical ...
Singh K, Lau CK, Manigrasso G, Gama JB, Gassmann R, Carter AP.   +5 more
europepmc   +3 more sources

A developmental and genetic classification for malformations of cortical development: update 2012. [PDF]

, 2012
Malformations of cerebral cortical development include a wide range of developmental disorders that are common causes of neurodevelopmental delay and epilepsy. In addition, study of these disorders contributes greatly to the understanding of normal brain
Barkovich, A James, Dobyns, William B, Guerrini, Renzo, Jackson, Graeme D, Kuzniecky, Ruben I   +4 more
core   +3 more sources

Lis1 controls dynamics of neuronal filopodia and spines to impact synaptogenesis and social behaviour

EMBO Molecular Medicine, 2013
LIS1 (PAFAH1B1) mutation can impair neuronal migration, causing lissencephaly in humans. LIS1 loss is associated with dynein protein motor dysfunction, and disrupts the actin cytoskeleton through disregulated RhoGTPases.
Anamaria Sudarov, Frank Gooden, Debbie Tseng, Wen‐Biao Gan, Margaret Elizabeth Ross   +4 more
doaj   +1 more source

Abnormalities in Cortical GABAergic Interneurons of the Primary Motor Cortex Caused by Lis1 (Pafah1b1) Mutation Produce a Non-drastic Functional Phenotype

Frontiers in Cell and Developmental Biology, 2022
LIS1 (PAFAH1B1) plays a major role in the developing cerebral cortex, and haploinsufficient mutations cause human lissencephaly type 1. We have studied morphological and functional properties of the cerebral cortex of mutant mice harboring a deletion in ...
E. Domínguez-Sala, L. Valdés-Sánchez, S. Canals, O. Reiner, A. Pombero, R. García-López, A. Estirado, D. Pastor, E. Geijo-Barrientos, S. Martínez, S. Martínez   +10 more
doaj   +1 more source

LIS1-Related Isolated Lissencephaly [PDF]

Archives of Neurology, 2009
With the largest data set of patients with LIS1-related lissencephaly, the major cause of posteriorly predominant lissencephaly related to either LIS1 mutation or intragenic deletion, described so far, we aimed to refine the spectrum of neurological and radiological features and to assess relationships with the genotype.Retrospective study.
Saillour, Yoann, Carion, Nathalie, Quelin, Chloe, Leger, Pierre-Louis, Boddaert, Nathalie, Elie, Caroline, Toutain, Annick, Mercier, Sandra, Barthez, Marie Anne, Milh, Mathieu, Joriot, Sylvie, Des Portes, Vincent, Philip, Nicole, Broglin, Dominique, Roubertie, Agathe, Pitelet, Gaëlle, Moutard, Marie Laure, Pinard, Jean-Marc, Cancès, Clément, Cances, Claude, Kaminska, Anna, Chelly, Jamel, Beldjord, Chérif, Bahi-Buisson, Nadia   +23 more
openaire   +3 more sources

Global developmental gene expression and pathway analysis of normal brain development and mouse models of human neuronal migration defects. [PDF]

PLoS Genetics, 2011
Heterozygous LIS1 mutations are the most common cause of human lissencephaly, a human neuronal migration defect, and DCX mutations are the most common cause of X-linked lissencephaly.
Tiziano Pramparo, Ondrej Libiger, Sonia Jain, Hong Li, Yong Ha Youn, Shinji Hirotsune, Nicholas J Schork, Anthony Wynshaw-Boris   +7 more
doaj   +1 more source

NudC regulated Lis1 stability is essential for the maintenance of dynamic microtubule ends in axon terminals

iScience, 2022
Summary: In the axon terminal, microtubule stability is decreased relative to the axon shaft. The dynamic microtubule plus ends found in the axon terminal have many functions, including serving as a docking site for the Cytoplasmic dynein motor. Here, we
Dane Kawano, Katherine Pinter, Madison Chlebowski, Ronald S. Petralia, Ya-Xian Wang, Alex V. Nechiporuk, Catherine M. Drerup   +6 more
doaj   +1 more source

Lis1 has two opposing modes of regulating cytoplasmic dynein [PDF]

Cell, 2017
SummaryRegulation is central to the functional versatility of cytoplasmic dynein, a motor involved in intracellular transport, cell division, and neurodevelopment. Previous work established that Lis1, a conserved and ubiquitous regulator of dynein, binds to its motor domain and induces a tight microtubule-binding state in dynein.
Morgan E. DeSantis, Michael A. Cianfrocco, Zaw Min Htet, Phuoc Tien Tran, Samara L. Reck‐Peterson, Andrés E. Leschziner   +5 more
openalex   +8 more sources