Results 61 to 70 of about 6,058 (200)

Brain Pathways in LIS1-Associated Lissencephaly Revealed by Diffusion MRI Tractography

Brain Sciences, 2023
Lissencephaly (LIS) is a rare neurodevelopmental disorder with severe symptoms caused by abnormal neuronal migration during cortical development. It is caused by both genetic and non-genetic factors.
Alpen Ortug, Briana Valli, José Luis Alatorre Warren, Tadashi Shiohama, Andre van der Kouwe, Emi Takahashi   +5 more
doaj   +1 more source

The mitosis and neurodevelopment proteins NDE1 and NDEL1 form dimers, tetramers and polymers with a folded-back structure in solution [PDF]

, 2012
Paralogs NDE1 (nuclear distribution element 1) and NDEL1 (NDE-like 1) are essential for mitosis and neurodevelopment. Both proteins are predicted to have similar structures, based upon high sequence similarity, and they co-complex in mammalian cells.
Alkuraya, Bakircioglu, Bariola, Bradshaw, Bradshaw, Bradshaw, Bradshaw, Brandon, Braun, Burdick, Chansard, Chen, Collins, Cox, Derewenda, Efimov, Feng, Guo, Hayashi, Ikeda, Ingason, Johnson, Kalkhof, Kirov, Lam, Laskowski, Leliveld, Liang, Ludtke, Magri, Maiolica, Matic, Mori, Narayanan, Need, Niethammer, Ong, Rappsilber, Rappsilber, Rappsilber, Sali, Sasaki, Segal, Shen, Shmueli, Tarricone, Toyo-oka, Ullmann, van Heel, Vriend, Wang, Yan, Zylkiewicz   +52 more
core   +1 more source

LIS1-Related Isolated Lissencephaly [PDF]

Archives of Neurology, 2009
With the largest data set of patients with LIS1-related lissencephaly, the major cause of posteriorly predominant lissencephaly related to either LIS1 mutation or intragenic deletion, described so far, we aimed to refine the spectrum of neurological and radiological features and to assess relationships with the genotype.Retrospective study.
Saillour, Yoann, Carion, Nathalie, Quelin, Chloe, Leger, Pierre-Louis, Boddaert, Nathalie, Elie, Caroline, Toutain, Annick, Mercier, Sandra, Barthez, Marie Anne, Milh, Mathieu, Joriot, Sylvie, Des Portes, Vincent, Philip, Nicole, Broglin, Dominique, Roubertie, Agathe, Pitelet, Gaëlle, Moutard, Marie Laure, Pinard, Jean-Marc, Cancès, Clément, Cances, Claude, Kaminska, Anna, Chelly, Jamel, Beldjord, Chérif, Bahi-Buisson, Nadia   +23 more
openaire   +3 more sources

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

Advanced Science, EarlyView.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei, Huiyan Ji, Jing Guo, Mengdi Liu, Danhua Su, Yiran Zheng, Lin Xu, Qinghua Cao, Tao Ren, Jun Gui, Zhenke Wen   +10 more
wiley   +1 more source

The Cytoplasmic Dynein Associated Protein NDE1 Regulates Osteoclastogenesis by Modulating M-CSF and RANKL Signaling Pathways

Cells, 2021
Cytoskeleton organization and lysosome secretion play an essential role in osteoclastogenesis and bone resorption. The cytoplasmic dynein is a molecular motor complex that regulates microtubule dynamics and transportation of cargos/organelles, including ...
Bhaba K. Das, Jyoti Gogoi, Aarthi Kannan, Ling Gao, Weirong Xing, Subburaman Mohan, Haibo Zhao   +6 more
doaj   +1 more source

Post‐LECA Origin and Diversification of an Axonemal Outer Arm Dynein Motor

Cytoskeleton, EarlyView.
ABSTRACT Dyneins were present in the last eukaryotic common ancestor (LECA) and play key roles in eukaryotic biology. Axonemal dyneins form the inner and outer arms that power ciliary beating, and it has long been recognized that outer arms in some organisms contain two different heavy chain motors, whereas those from other species contain a third unit
Stephen M. King
wiley   +1 more source

Lissencephaly-1 is a context-dependent regulator of the human dynein complex

eLife, 2017
The cytoplasmic dynein-1 (dynein) motor plays a central role in microtubule organisation and cargo transport. These functions are spatially regulated by association of dynein and its accessory complex dynactin with dynamic microtubule plus ends. Here, we
Janina Baumbach, Andal Murthy, Mark A McClintock, Carly I Dix, Ruta Zalyte, Ha Thi Hoang, Simon L Bullock   +6 more
doaj   +1 more source

NudCD1 as a prognostic marker in colorectal cancer and its role in the upregulation of cellular spindle assembly checkpoint genes and LIS1 pathways

BMC Cancer, 2022
Objective To investigate the role of NudCD1 in spindle assembly checkpoint regulation and in the prognosis of colorectal cancer.  Methods Immunohistochemical staining was used to detect in situ expression of NudCD1 in 100 colorectal cancer tissue samples.
Wen-Ming Feng, Hui Gong, Yong-Chun Wang, Yao Wang, Tao Xue, Ting Zhang, Ge Cui   +6 more
doaj   +1 more source

GENOTYPE-PHENOTYPE CORRELATION IN CASES WITH LISSENCEPHALY SPECTRUM

Sabiad, 2022
Objective: In this study, we aimed to evaluate six cases diagnosed with lissencephaly in terms of the genotype-phenotype correlation. Materials and Methods: Six cases with lissencephaly, which were followed up in our outpatient clinic, were included in ...
Ayça Dilruba Aslanger, Zehra Oya Uyguner, Birsen Karaman, Seher Başaran, Hülya Kayserili Karabey   +4 more
doaj   +1 more source

DISC1 genetics, biology and psychiatric illness [PDF]

, 2013
Psychiatric disorders are highly heritable, and in many individuals likely arise from the combined effects of genes and the environment. A substantial body of evidence points towards DISC1 being one of the genes that influence risk of schizophrenia ...
A. Amador-Arjona, A. Ames 3rd, A. Chen, A. Crepel, A. D. Lopez, A. Dammermann, A. Enomoto, A. Giorgio Di, A. Guven, A. Hayashi-Takagi, A. Honda, A. Ingason, A. J. Ramsey, A. K. Alkhaja, A. K. Kähler, A. Kamiya, A. Kamiya, A. Louvi, A. Marley, A. Meyer-Lindenberg, A. Olincy, A. R. Kriegstein, A. Ram Murthy, A. Rastogi, A. Rauch, A. Raznahan, A. Schosser, A. Serretti, A. Steinecke, A. Wynshaw-Boris, A. Wynshaw-Boris, B. A. Karpinski, B. Abazyan, B. C. Carlyle, B. J. Maher, B. K. Tiwary, B. Kirkpatrick, C. H. Chiang, C. Korth, C. Korth, C. L. Frank, C. Lam, C. M. Drerup, C. Ott, C. P. Austin, D. Bartsch, D. C. Soares, D. H. Blackwood, D. Ibi, D. M. Collins, D. P. Prata, D. P. Prata, D. Porteous, D. R. Lemos, D. Wu, D. Zhou, E. A. Nigg, E. K. Green, E. K. Green, E. Kang, E. L. Malavasi, E. S. Gershon, E. Spiteri, E. Sprooten, F. H. Lee, F. Hildebrandt, F. Mouaffak, F. N. Haque, F. Papaleo, F. S. Alkuraya, F. Silva Alves da, F. Zheng, G. B. John, G. Chakirova, G. M. Rice, G. Rienzo De, G. T. Rezin, G. W. Beecham, H. B. Clay, H. C. Whalley, H. J. Carlisle, H. Koike, H. Le-Niculescu, H. Murdoch, H. Murdoch, H. R. Higginbotham, H. Shoji, H. Toda, I. Filges, I. Mata, I. Mathieson, J. A. Lee, J. A. Morris, J. A. Siuciak, J. An, J. C. Crabbe, J. D. Wood, J. E. Buizer-Voskamp, J. E. Chubb, J. E. Eykelenboom, J. E. Landers, J. E. Zimmerman, J. H. Callicott, J. Ikuta, J. J. Breunig, J. K. Millar, J. K. Millar, J. K. Millar, J. K. Millar, J. K. Millar, J. Os van, J. P. McEvoy, J. S. Domire, J. Schumacher, J. Y. Kim, J. Y. Kim, J. Yingling, J.M. Williams, K. Ameri, K. D. Meyer, K. E. Burdick, K. E. Miller, K. Ishizuka, K. Jepsen, K. K. Nicodemus, K. K. Singh, K. K. Singh, K. Kubo, K. Kuroda, K. Maeda, K. Miyoshi, K. Miyoshi, K. Mykytyn, K. Nakata, K. R. Rosenbloom, K. Tomita, K. Ushijima, K. Wulff, K. Wulff, L. A. Greene, L. K. Paul, L. M. Houlihan, L. Ma, L. N. Moens, L. V. Kristiansen, L.M. Camargo, M. A. Carless, M. A. Trinh, M. Ayalew, M. Bakircioglu, M. Costa-Mattioli, M. Costa-Mattioli, M. D. Houslay, M. Gentile, M. Händel, M. Kuijpers, M. Kvajo, M. Kvajo, M. M. Chakravarty, M. Niwa, M. S. Taylor, M. V. Pletnikov, M. Valiente, M. Yi, M.J. Puthuran, N. A. Sachs, N. D. Hanson, N. F. Berbari, N. J. Bradshaw, N. J. Bradshaw, N. J. Bradshaw, N. J. Brandon, N. J. Brandon, N. J. Brandon, N. Kumamoto, N. Osbun, N. Sawamura, N. Sawamura, O. M. Palo, O. Reiner, O. Zuk, P. A. Thomson, P. F. Sullivan, P. Jia, P. Katsel, P. Ottis, P. R. Szeszko, P. Saetre, P. Schulz, Q. Wang, Q. Wei, R. 3. Flores, R. Boxall, R. Debono, R. Hashimoto, R. James, R. L. Faulkner, R. M. Walker, S. Brauns, S. C. Vernes, S. Chiba, S. E. Harris, S. Hoppins, S. J. Clapcote, S. Kim, S. Koyanagi, S. L. Eastwood, S. L. Eastwood, S. M. Brown, S. Narayanan, S. R. Leliveld, S. R. Leliveld, S. Sasaki, S. Seshadri, S. Shen, S. Shimizu, S. Taya, S. Y. Chen, T. A. Atkin, T. A. Atkin, T. A. Green, T. D. Cannon, T. Fujita, T. Fukuda, T. Hikida, T. Igarashi, T. J. Stuhlmiller, T. L. Gasperoni, T. L. Young-Pearse, T. L. Young-Pearse, T. Nagai, T. Namba, T. Shinoda, T. Takahashi, T. V. Lipina, T. V. Lipina, T. V. Lipina, V. M. Pogorelov, W. Hennah, W. Hennah, W. Hennah, W. Li, W. Song, W. Song, X. Duan, X. J. Han, X. Zhou, X. Zhou, Y. Feng, Y. G. Han, Y. Hotta, Y. Mao, Y. Ozeki, Y. U. Park, Y. Wang, Y. Watatani   +255 more
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