Results 71 to 80 of about 8,390 (226)

Lissencephaly-1 dependent axonal retrograde transport of L1-type CAM Neuroglian in the adult drosophila central nervous system. [PDF]

PLoS ONE, 2017
Here, we established the Drosophila Giant Fiber neurons (GF) as a novel model to study axonal trafficking of L1-type Cell Adhesion Molecules (CAM) Neuroglian (Nrg) in the adult CNS using live imaging.
Sirisha R Kudumala, Tyrone Penserga, Jana Börner, Olesya Slipchuk, Priyanka Kakad, LaTasha H Lee, Aater Qureshi, Jan Pielage, Tanja A Godenschwege   +8 more
doaj   +1 more source

Interplay of LIS1 and MeCP2: Interactions and Implications With the Neurodevelopmental Disorders Lissencephaly and Rett Syndrome

Frontiers in Cellular Neuroscience, 2019
LIS1 is the main causative gene for lissencephaly, while MeCP2 is the main causative gene for Rett syndrome, both of which are neurodevelopmental diseases.
Liraz Keidar, Gabi Gerlitz, Aditya Kshirsagar, Michael Tsoory, Tsviya Olender, Xing Wang, Ying Yang, Yu-Sheng Chen, Yun-Gui Yang, Irina Voineagu, Orly Reiner   +10 more
doaj   +1 more source

Special Values of Generalized Polylogarithms

, 2007
We study values of generalized polylogarithms at various points and relationships among them. Polylogarithms of small weight at the points 1/2 and -1 are completely investigated. We formulate a conjecture about the structure of the linear space generated
D Bowman, EA Ulanskii, HN Minh, HRP Ferguson, J Sondow, JAM Vermaseren, JM Borwein, L Lewin, M Abramowitz, ME Hoffman, N Nielsen, P Deligne, P Flajolet, S. A. Zlobin, SA Zlobin, T Terasoma, VN Sorokin, WW Zudilin   +17 more
core   +1 more source

DISC1 is needed for the organization of cellular components at the immunological synapse. [PDF]

, 2019
T-cells carry out their immune functions through receptor-based recognition and adhesion to target cells. The cell-cell junction that is created from this connection is known as the immunological synapse (IS); a cellular structure composed of organized ...
Ramakrishnan, Adarsh
core   +1 more source

The Cytoplasmic Dynein Associated Protein NDE1 Regulates Osteoclastogenesis by Modulating M-CSF and RANKL Signaling Pathways

Cells, 2021
Cytoskeleton organization and lysosome secretion play an essential role in osteoclastogenesis and bone resorption. The cytoplasmic dynein is a molecular motor complex that regulates microtubule dynamics and transportation of cargos/organelles, including ...
Bhaba K. Das, Jyoti Gogoi, Aarthi Kannan, Ling Gao, Weirong Xing, Subburaman Mohan, Haibo Zhao   +6 more
doaj   +1 more source

Assessment of Molecular Cytogenetic Methods for the Detection of Chromosomal Abnormalities [PDF]

, 2006
Some marker chromosomes and chromosome rearrangements are difficult to identify using G-bands by Giemsa staining after trypsin treatment (G-banding) alone.
Maruyama, Hidehiko, Morishima, Tsuneo, Ninomiya, Shinsuke, Shinozuka, Masako, Une, Tomoka, Yokoyama, Yuji   +5 more
core   +1 more source

Genetic Mosaic Dissection of Lis1 and Ndel1 in Neuronal Migration [PDF]

Neuron, 2010
Coordinated migration of newly born neurons to their prospective target laminae is a prerequisite for neural circuit assembly in the developing brain. The evolutionarily conserved LIS1/NDEL1 complex is essential for neuronal migration in the mammalian cerebral cortex. The cytoplasmic nature of LIS1 and NDEL1 proteins suggest that they regulate neuronal
Kazunari Miyamichi, Anthony Wynshaw-Boris, Simon Hippenmeyer, Liqun Luo, Yong Ha Youn, Hyang Mi Moon, Hui Zong, Hui Zong   +7 more
openaire   +3 more sources

NudCD1 as a prognostic marker in colorectal cancer and its role in the upregulation of cellular spindle assembly checkpoint genes and LIS1 pathways

BMC Cancer, 2022
Objective To investigate the role of NudCD1 in spindle assembly checkpoint regulation and in the prognosis of colorectal cancer.  Methods Immunohistochemical staining was used to detect in situ expression of NudCD1 in 100 colorectal cancer tissue samples.
Wen-Ming Feng, Hui Gong, Yong-Chun Wang, Yao Wang, Tao Xue, Ting Zhang, Ge Cui   +6 more
doaj   +1 more source

GENOTYPE-PHENOTYPE CORRELATION IN CASES WITH LISSENCEPHALY SPECTRUM

Sabiad, 2022
Objective: In this study, we aimed to evaluate six cases diagnosed with lissencephaly in terms of the genotype-phenotype correlation. Materials and Methods: Six cases with lissencephaly, which were followed up in our outpatient clinic, were included in ...
Ayça Dilruba Aslanger, Zehra Oya Uyguner, Birsen Karaman, Seher Başaran, Hülya Kayserili Karabey   +4 more
doaj   +1 more source

The mitosis and neurodevelopment proteins NDE1 and NDEL1 form dimers, tetramers and polymers with a folded-back structure in solution [PDF]

, 2012
Paralogs NDE1 (nuclear distribution element 1) and NDEL1 (NDE-like 1) are essential for mitosis and neurodevelopment. Both proteins are predicted to have similar structures, based upon high sequence similarity, and they co-complex in mammalian cells.
Alkuraya, Bakircioglu, Bariola, Bradshaw, Bradshaw, Bradshaw, Bradshaw, Brandon, Braun, Burdick, Chansard, Chen, Collins, Cox, Derewenda, Efimov, Feng, Guo, Hayashi, Ikeda, Ingason, Johnson, Kalkhof, Kirov, Lam, Laskowski, Leliveld, Liang, Ludtke, Magri, Maiolica, Matic, Mori, Narayanan, Need, Niethammer, Ong, Rappsilber, Rappsilber, Rappsilber, Sali, Sasaki, Segal, Shen, Shmueli, Tarricone, Toyo-oka, Ullmann, van Heel, Vriend, Wang, Yan, Zylkiewicz   +52 more
core   +1 more source