Results 81 to 90 of about 6,058 (200)

Cytoplasmic dynein and its regulatory proteins in Golgi pathology in nervous system disorders

Frontiers in Neuroscience, 2015
The Golgi apparatus is a dynamic organelle involved in processing and sorting of lipids and proteins. In neurons, the Golgi apparatus is important for the development of axons and dendrites and maintenance of their highly polarized morphology.
Dick eJaarsma, Casper eHoogenraad
doaj   +1 more source

Studies of Recombinant TWA1 Reveal Constitutive Dimerization [PDF]

, 2017
The mammalian muskelin/RanBP9/C-terminal to LisH (CTLH) complex and the Saccharomyces cerevisiae glucose-induced degradation (GID) complex are large, multi-protein complexes that each contain a RING E3 ubiquitin ligase.
Adams, Jo, Baker, Genevieve, Francis, Ore, Race, Paul   +3 more
core   +3 more sources

Aetiopathogenesis of infantile epileptic spasms syndrome and mechanisms of action of adrenocorticotrophin hormone/corticosteroids in children: A scoping review

Developmental Medicine &Child Neurology, Volume 67, Issue 8, Page 1004-1025, August 2025.
Why does infantile epileptic spasms syndrome (IESS) occur with a variety of underlying conditions and why does it respond to adrenocorticotrophin hormone (ACTH)/corticosteroids? Our scoping review summarizes five hypotheses from the literature: gene/epigenetic regulation, stress/HPA axis activation, neuroinflammation/immune function, altered neuronal ...
Emily A. Innes, Velda X. Han, Shrujna Patel, Michelle A. Farrar, Deepak Gill, Shekeeb S. Mohammad, Russell C. Dale   +6 more
wiley   +1 more source

The Autism Related Protein Contactin-Associated Protein-Like 2 (CNTNAP2) Stabilizes New Spines: An In Vivo Mouse Study. [PDF]

, 2015
The establishment and maintenance of neuronal circuits depends on tight regulation of synaptic contacts. We hypothesized that CNTNAP2, a protein associated with autism, would play a key role in this process.
Gdalyahu, Amos, Geschwind, Daniel H, Golshani, Peyman, Lazaro, Maria, Penagarikano, Olga, Trachtenberg, Joshua T   +5 more
core   +2 more sources

Cryo-EM captures early intermediate steps in dynein activation by LIS1

Nature Communications
Cytoplasmic dynein-1 (dynein) is an essential molecular motor in eukaryotic cells. Dynein primarily exists in an autoinhibited Phi state and requires conformational changes to assemble with its cofactors and form active transport complexes.
Kendrick H. V. Nguyen, Eva P. Karasmanis, Agnieszka A. Kendrick, Samara L. Reck-Peterson, Andres E. Leschziner   +4 more
doaj   +1 more source

Centromere Protein F in Tumor Biology: Cancer's Achilles Heel

Cancer Medicine, Volume 14, Issue 10, May 2025.
ABSTRACT Background Centromere protein F (CENP‐F) is an important nuclear matrix protein that regulates mitosis and the cell cycle, and plays a crucial role in recruiting spindle checkpoint proteins to maintain the accuracy of chromosome segregation.
Zitong Wan, Miaomiao Wen, Chunlong Zheng, Ying Sun, Yinxi Zhou, Yahui Tian, Shaowei Xin, Xuejiao Wang, Xiaohong Ji, Jie Yang, Yanlu Xiong, Yong Han   +11 more
wiley   +1 more source

Conformational heterogeneity coupled with β-fibril formation of a scaffold protein involved in chronic mental illnesses

Translational Psychiatry, 2021
Chronic mental illnesses (CMIs) pose a significant challenge to global health due to their complex and poorly understood etiologies and hence, absence of causal therapies.
Abhishek Cukkemane, Nina Becker, Mara Zielinski, Benedikt Frieg, Nils-Alexander Lakomek, Henrike Heise, Gunnar F. Schröder, Dieter Willbold, Oliver H. Weiergräber   +8 more
doaj   +1 more source

Emerging Trends of Nanotechnology towards Picotechnology: Energy and Biomolecules [PDF]

, 2010
In nature, metal oxide particles display their existence at the level of picomolecules in solution state and bioactive states in the body. We present evidence of picomolar behavior of molecules different than nanomolar behavior of particles.
Avdhesh Sharma, Ching J. Chen, Rakesh Sharma   +2 more
core   +2 more sources

Behavioral and other phenotypes in a cytoplasmic Dynein light intermediate chain 1 mutant mouse [PDF]

, 2011
The cytoplasmic dynein complex is fundamentally important to all eukaryotic cells for transporting a variety of essential cargoes along microtubules within the cell. This complex also plays more specialized roles in neurons.
AlQatari, Mona, Banks, Gareth T, Haas, Matilda A, Hafezparast, Majid, Line, Samantha, others,, Philpott, Amelia, Rishal, Ida, Shepherd, Hazel L, Stewart, Sammy   +9 more
core   +1 more source

Antecedents and outcomes of consumer environmentally friendly attitudes and behaviour [PDF]

, 2010
With the intensification of problems relating to the environment, a growing number of consumers are becoming more ecologically conscious in their preferences and purchases of goods.
Aitken L., Bentler P.M., Byrne B.M., Constantinos N. Leonidou, Dunlap R.E., Eigner S., Ellen P.S., Festinger L., Flatters P., García-Rosell J.-C., Hair J.F., Hofstede G., Hofstede G., Jones A., Kim Y., Kline R.B., Leonidas C. Leonidou, Levin G., Light H., Mayer F.S., McCarty J., Melillo W., Newell S.J., Nigbur D., Nisbet E.K., Nunnally J.C., O'Neill J., Olga Kvasova, Olli E., Paim L., Paladino A., Pickett G.M., Porritt J., Schuhwerk M.E., Shabecoff P., Sinha J.B.P., Sohr S., Solomon M., Triandis H.C.   +38 more
core   +3 more sources