Results 241 to 250 of about 26,671 (292)

Organoids in Cancer Research and Regenerative Medicine: Current Status, Challenges, and Future Prospects. [PDF]

MedComm (2020)
Li R, Wu Y, Zheng Z, Zhou F, Xu K, Su J.
europepmc   +1 more source

Precision modulation of tumor excitability: Targeting cell phenotypic heterogeneity for next‐generation cancer therapy

BMEMat, EarlyView.
This Perspective introduces tumor electrical excitability as a previously overlooked dimension of cancer biology. It proposes that tumor–neural interactions enable malignant cells to acquire neuron‐like properties and form bidirectional chemical and electrical communications with nerves.
Zonghao Liu, Xingwu Jiang, Gang Liu, Jian Chen, Kun Song, Xu Li, Siew Yee Wong, Ruicheng Shi, Yanyan Liu, Wenbo Bu   +9 more
wiley   +1 more source

Organoids for disease modeling and treatment: state-of-the-art. [PDF]

Exp Hematol Oncol
Xu M, Kong D, Sun S, Wang Y, Su G, Zhang S, Yan J, Han Z, Li J, Zhang L.   +9 more
europepmc   +1 more source

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, EarlyView.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

A convective transport-enhanced multi-organoid device for therapeutic modeling of the liver-pancreas axis in obesity. [PDF]

Theranostics
Kim J, Bae J, Cui B, Cho SW, Yang K.
europepmc   +1 more source

Capability Development in the European Medicines Regulatory Network—A European Learning Needs Analysis and Survey Study

Clinical Pharmacology &Therapeutics, EarlyView.
The European Medicines Regulatory Network plays a critical role in safeguarding public health through the assessment and supervision of human medicines. However, rapid scientific and technological advancements have exposed capability deficits across the network, threatening timely and effective regulatory decision‐making.
Naomi Beard, Marko J. Kallio, Luca Kosec, Ulrika Espefält Westin, on behalf of the IncreaseNET consortium   +4 more
wiley   +1 more source

Advances in In Vitro Vascularization of Engineered Tissues: From Microvessel Formation to Hepatic Tissue Integration. [PDF]

Regen Ther
Huang YH, Ono A, Sudo R.
europepmc   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

4D fabrication of scaffolds facilitates the construction of cholangiocyte monolayers from human and mouse liver derived organoids. [PDF]

Mater Today Bio
Li J, Chen S, Chu J, Fei Y, Chung PH, Wong KKY, Lui VCH, Tam PKH.   +7 more
europepmc   +1 more source

Harnessing induced pluripotent stem cells and organoids for disease modeling and precision medicine. [PDF]

Stem Cell Res Ther
Lee CJ, Nam Y, Rim YA, Ju JH.
europepmc   +1 more source