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Liver Organoids: Formation Strategies and Biomedical Applications
Tissue Engineering and Regenerative Medicine, 2021The liver is the most important digestive organ in the body. Several studies have explored liver biology and diseases related to the liver. However, most of these studies have only explored liver development, mechanism of liver regeneration and pathophysiology of liver diseases mainly based on two-dimensional (2D) cell lines and animal models ...
Xinglong Zhu +3 more
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Ethical challenges for pediatric liver organoid transplantation
Science Translational Medicine, 2020The authors discuss whether it is ethically acceptable to include children in a first-in-human clinical trial of liver organoid transplantation.
Sarah A. Schneemann +5 more
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2017
The development of novel and consistent biologic surrogates for drug discovery, toxicology, and cancer research is presently intense and involves a growing number of research groups and institutions around the world. The Twilight of the days of immortalized cell lines as the workhorse of most of our drug development and cancer research efforts seem now
Estela Solanas +6 more
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The development of novel and consistent biologic surrogates for drug discovery, toxicology, and cancer research is presently intense and involves a growing number of research groups and institutions around the world. The Twilight of the days of immortalized cell lines as the workhorse of most of our drug development and cancer research efforts seem now
Estela Solanas +6 more
openaire +1 more source
Transcriptome-Guided Design of Physiological Multilineage Liver Organoids
Trends in Genetics, 2021Despite several technical challenges, human induced pluripotent stem cell (hiPSC)-derived organoids enable biologically and clinically relevant functional study of physiology and disease. In a recent Cell Systems article, Velazquez et al. report a novel strategy to identify regulators of multilineage organoid maturation by reverse-engineering from the ...
Zhu, Shijia +2 more
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Hybrid Artificial Liver Using Hepatocyte Organoid Culture
Artificial Organs, 2001Abstract: We developed 2 types of hybrid artificial liver modules using hepatocyte organoid culture. One was a polyurethane foam (PUF)/hepatocyte spheroid packed‐bed module. Hepatocytes spontaneously formed spheroids in the PUF pores, and they maintained liver‐specific functions well for at least 2 weeks in vitro.
K, Funatsu +5 more
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Organoids derived from digestive tract, liver, and pancreas
Journal of Digestive Diseases, 2016Lgr5 marks stem cells in digestive epithelial tissues by lineage tracing, and in vitro ever‐expansion of Lgr5 stem cells form organoids, which can be directed to differentiate into functional somatic cells. Organoids derived from gastrointestinal epithelium even recapitulate the morphologic features of their in vivo counterpart.
An Tao, Xu, Jin Lu, Tong, Zhi Hua, Ran
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Three‐dimensional liver‐derived extracellular matrix hydrogel promotes liver organoids function
Journal of Cellular Biochemistry, 2018AbstractAn important advantage of employing extracellular matrix (ECM)‐derived biomaterials in tissue engineering is the ability to tailor the biochemical and biophysical microenvironment of the cells. This study aims to assess whether three‐dimensional (3D) liver‐derived ECM hydrogel (LEMgel) promotes physiological function of liver organoids ...
Mona Saheli +6 more
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Industrially Scalable Human Liver Organoids
2015Tissue engineering research is a multidisciplinary effort that incorporates the use of resources from various fields to address specific problems. Biomatrix scaffolds have recently been more widely used to improve the culture of cells by supporting their differentiated functions more than any known matrix extract or purified matrix component.
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Organoid-guided precision hepatology for metabolic liver disease
Journal of HepatologyMetabolic dysfunction-associated steatotic liver disease affects millions of people worldwide. Progress towards a definitive cure has been incremental and treatment is currently limited to lifestyle modification. Hepatocyte-specific lipid accumulation is the main trigger of lipotoxic events, driving inflammation and fibrosis.
Sho Osonoi, Takanori Takebe
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En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH
Cell, 2022Takanori Takebe
exaly