Results 101 to 110 of about 35,405 (287)

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

Efficient hepatocyte differentiation of primary human hepatocyte-derived organoids using three dimensional nanofibers (HYDROX) and their possible application in hepatotoxicity research

Scientific Reports
Human liver organoids are in vitro three dimensionally (3D) cultured cells that have a bipotent stem cell phenotype. Translational research of human liver organoids for drug discovery has been limited by the challenge of their low hepatic function ...
Yanran Tong, Yukiko Ueyama-Toba, Jumpei Yokota, Hayato Matsui, Masaki Kanai, Hiroyuki Mizuguchi   +5 more
doaj   +1 more source

A Review on the Application of Organoids in Food Science Research [PDF]

Shipin Kexue
Organoids are three-dimensional cell cultures that possess some key properties of organs, and their application in food science research has been increasingly emphasized.
MA Aijin, BAI Rujin, ZHOU Junjun, JIA Yingmin
doaj   +1 more source

Decellularized Extracellular Matrix Scaffolds to Engineer the Dormant Landscape of Microscopic Colorectal Cancer Liver Metastasis

Advanced Healthcare Materials, EarlyView.
Decellularized liver extracellular matrix scaffolds provide a platform to study dormant liver‐metastatic colorectal cancer. They induce reversible dormancy, in combination with nutrient depletion and low dose chemotherapy, through cell cycle arrest and chemotherapy resistance.
Sabrina N. VandenHeuvel, Lucia L. Nash, Abigail J. Clevenger, Claudia A. Collier, Oscar R. Benavides, Sanjana Roy, Brinlee Goggans, Aelita Salikhova, Anvitha Tharakesh, Svasti Haricharan, Amber N. Stratman, Scott Kopetz, Alex J. Walsh, Shreya A. Raghavan   +13 more
wiley   +1 more source

Cholangiocyte Organoids in Liver Transplantation; a Comprehensive Review

Transplant International
Liver transplantation is the only curative option for many liver diseases that end up in liver failure, and cholangiopathy remains a challenging complication post-liver transplant, associated with significant morbidity and potential graft loss.
C. Rejas, H. Junger
doaj   +1 more source

Customized liver organoids as an advanced in vitro modeling and drug discovery platform for non-alcoholic fatty liver diseases [PDF]

, 2023
Dong‐Wook Han, KangHe Xu, Zhe‐Long Jin, Yongnan Xu, Yinghua Li, Lin Wang, Qilong Cao, Kee-Pyo Kim, Dong Hee Ryu, Kwonho Hong, Hyung Nam Kim   +10 more
openalex   +1 more source

Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells. [PDF]

, 2015
The field of tissue engineering entered a new era with the development of human pluripotent stem cells (hPSCs), which are capable of unlimited expansion whilst retaining the potential to differentiate into all mature cell populations.
Brafman, David, Bush, Kevin T, Cutts, Josh, Gaasterland, Terry, Kumar, Nathan, Nigam, Sanjay K, Richter, Jenna, Trujillo, Cleber, Willert, Karl   +8 more
core   +3 more sources

Ultrasound‐Triggered Gelation for Restoring Biomechanical Properties of Degenerated Functional Spinal Units

Advanced Healthcare Materials, EarlyView.
This study introduces an innovative approach to treating intervertebral disc degeneration using ultrasound‐triggered in situ hydrogel formation. Proof‐of‐concept experiments using optimized biomaterial and ultrasound parameters demonstrate partial restoration of biomechanical function and successful integration into degenerated disc tissue, offering a ...
Veerle A. Brans, Anna P. Constantinou, Matthew J. Kibble, Valeria Nele, Daniel Reumann, Luca Bau, Sebastien J. P. Callens, James P. K. Armstrong, Nicolas Newell, Constantin C. Coussios, Molly M. Stevens, Michael D. Gray   +11 more
wiley   +1 more source

Canonical Wnt signalling is activated during BEC-to-hepatocyte conversion in vivo and modulates liver epithelial cell plasticity in hepatic organoids [PDF]

, 2020
Eider Valle-Encinas, Niya Aleksieva, Carmen Velasco Martinez, Michael Dawes, Matthew Zverev, Miryam Müller, Anika Offergeld, Matthew J. Smalley, Catherine Hogan, Stuart J. Forbes, Thomas G. Bird, Trevor Dale   +11 more
openalex   +1 more source

Human liver organoids generated with single donor-derived multiple cells rescue mice from acute liver failure [PDF]

, 2018
BackgroundAcute liver failure (ALF) is a life-threatening disease with a high mortality rate. However, there are limited treatments or devices available for ALF therapy.
Miyagi Etsuko, Nie Yun-Zhong, Ogawa Miyuki, Taniguchi Hideki, Zheng Yun-Wen, 鄭 允文   +5 more
core   +2 more sources