Results 181 to 190 of about 35,405 (287)

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Novel Vascularized Human Liver Organoids for Modeling Alcohol‐Induced Liver Injury and Developing Hepatoprotective Therapy

Advanced Science, EarlyView.
This study successfully engineered vascularized liver organoids (3HLOs) by co‐culturing human reprogrammed hepatocyte‐like cells (hrHLs) with human umbilical vein endothelial cells (HUVECs) and human umbilical mesenchymal stem cells (HUMSCs). Upon implantation, the 3HLOs established functional vascular anastomosis with the host circulation and ...
Kangdi Yang, Xiayan Chu, Xuerui Wang, Wenkun Zhang, Jinnuo Lu, Chuting Xu, Shoucheng Hu, Guoyu Pan, Chih‐Tsung Yang, Xiaohui Zhang, Shaojin Li, Zhaobin Guo, Hanyang Liu, Guangbo Ge   +13 more
wiley   +1 more source

Synthetic augmentation of bilirubin metabolism in human pluripotent stem cell-derived liver organoids. [PDF]

Stem Cell Reports, 2023
Reza HA, Farooqui Z, Reza AA, Conroy C, Iwasawa K, Ogura Y, Okita K, Osafune K, Takebe T.   +8 more
europepmc   +1 more source

Pharmacodynamic Studies of Fluorescent Diamond Carriers of Doxorubicin in Liver Cancer Cells and Colorectal Cancer Organoids

, 2021
Ron Firestein, Cezary Marcinkiewicz, Linyan Nie, H. Chua, Inés Velázquez‐Quesada, Marco D. Torelli, Mark Sternberg, Bojana Gligorijevic, Olga Shenderova, Romana Schirhagl, Giora Feuerstein   +10 more
openalex   +2 more sources

Conformable Device for Independent Measurements of Mucosal and Vascular Barriers in a Complex In Vitro Intestinal Model

Advanced Science, EarlyView.
Development of more complex in vitro models necessitates the development of improved monitoring approaches. This work demonstrates a novel conformable device capable of measuring the resistance of two cell barriers within a single model independently, a significant advantage over conventional trans‐epithelial/endothelial electrical resistance (TEER ...
Alexandra Elisabeth Wheeler, Sonja Blasche, Rob Bradley, Rachana Acharya, Sophie Oldroyd, David Bulmer, Kiran R. Patil, Róisín Meabh Owens   +7 more
wiley   +1 more source

Toward Transplantation of Liver Organoids: From Biology and Ethics to Cost-effective Therapy. [PDF]

Transplantation, 2023
Ten Dam MJM, Frederix GWJ, Ten Ham RMT, van der Laan LJW, Schneeberger K.   +4 more
europepmc   +1 more source

Regenerative Human Liver Organoids (Hlos) in a Pillar/Perfusion Plate for Hepatotoxicity Assays

Moo‐Yeal Lee, Sunil Shrestha, Prabha Acharya, Soo Yeon Kang, Manav Goud Vanga, L. Vinod Kumar Reddy, Jiafeng Liu, Yong Yang, Pranav Joshi   +8 more
openalex   +1 more source

Drug screening against complement disorders using human stem cell-derived endothelium and liver organoids

, 2020
Yasunori Nio, Momoko Ohori, Eri Kawakami, Tadahiro Shinozawa, Norikazu Saiki, Takanori Takebe   +5 more
openalex   +1 more source

Elemene Augments the Effects of Anti‐PD‐1 Immunotherapy on Hepatocellular Carcinoma by Regulating the miR‐130a‐5p/SPP/MHC‐I Axis

Advanced Science, EarlyView.
Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang, Mengqing Sun, Heng Dong, Xiaoting Zhang, Jingbo Zhang, Zhengguo Zhang, Mengjie Ni, Lina Li, Yunxin Pei, Xiaoyu Chen, Qian Li, Fangtian Bu, Jiacheng Huang, Liangyu Jiang, Zhuting Fang, Xuliang Chen, Jianxiang Chen, Yiting Qiao, Tian Xie   +18 more
wiley   +1 more source

Expandable liver organoids generated from human chemically derived hepatic progenitor enable alcoholic liver modeling

, 2022
Elsy Soraya SALAS SILVA, Yohan KIM, Myounghoi Kim, Taehun KIM, Daekwan SEO, Jaeming JEONG, Dongho Choi   +6 more
openalex   +2 more sources