Results 241 to 250 of about 35,405 (287)

Generation of Multicellular 3D Liver Organoids From Induced Pluripotent Stem Cells as a Tool for Modelling Liver Diseases. [PDF]

Bio Protoc
Maepa SW, Marakalala MJ, Ndlovu H.
europepmc   +1 more source

Mesenchymal stem cell-derived extracellular vesicles attenuate periductal fibrosis by inhibiting Th17 differentiation in human liver multilineage organoids and Mdr2−/− mice [PDF]

Wenyi Chen, Xinyi Chen, Feiqiong Gao, Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Jinfeng Yang, Guanghua Ma, Jianan Gong, Qian Li, Yunhua Chen, Lee Wei Lim, Ilia Stambler, Georgina M. Ellison, Brun Ulfhake, Robert Chunhua Zhao, Hongcui Cao   +17 more
openalex   +1 more source

One‐Step Coaxial 3D Printing of Pre‐Vascularized Skin Organoid Models with ADSC Microspheres for Enhanced Wound Healing

Advanced Science, EarlyView.
A multifunctional vascular bed platform is created using coaxial 3D printing, allowing the one‐step integration of organoid microspheres with perfusable vascular structures. This strategy enables rapid and functional vascularization of organoids to support tissue repair and vascularization, providing a scalable and translationally promising approach ...
Kunrui Wang, Xiang Lan, Jianwei Chen, Yu Wu, Delong Zhu, Xiangkai Kong, Ying Hu, Qian Liu, Kun Wang, Tao Xu, Lei Zhu   +10 more
wiley   +1 more source

Establishment and characterization of turtle liver organoids provides a potential model to decode their unique adaptations. [PDF]

Commun Biol
Zdyrski C, Gabriel V, Gessler TB, Ralston A, Sifuentes-Romero I, Kundu D, Honold S, Wickham H, Topping NE, Sahoo DK, Bista B, Tamplin J, Ospina O, Piñeyro P, Arriaga M, Galan JA, Meyerholz DK, Allenspach K, Mochel JP, Valenzuela N.   +19 more
europepmc   +1 more source

Endothelial Cell‐Based Vascular Bandages for Blood–Brain Barrier Repair and Targeted siRNA Delivery

Advanced Science, EarlyView.
mECs restore blood–brain barrier function after cerebral ischemia–reperfusion by simultaneously targeting, supporting, and regulating the damaged vasculature. mECs home to injured cerebral vessels through interactions with highly expressed VLA‐4, reinforce endothelial integrity by forming new junctions, and, upon OGD‐SN treatment, acquire enhanced ...
Yaosheng Li, Yunfei Dong, Yaode He, Juanjuan Zheng, Hui Liu, Lu Li, Xiaoxu Hao, Yanli Zhao, Zefeng Yang, Yuankai Sun, Zhiwei Du, Bo Zhao, Weihang Zhou, Honghui Wu, Tianyuan Zhang, Jiahe Wu, Xiangrui Liu, Xianzhen Yin, Zhicai Chen, Rui Xue, Min Lou, Zhen Gu, Xinchi Jiang, Jianqing Gao   +23 more
wiley   +1 more source

A High-Throughput Microphysiological Liver Chip System to Model Drug-Induced Liver Injury Using Human Liver Organoids. [PDF]

Gastro Hep Adv
Meyer SR, Zhang CJ, Garcia MA, Procario MC, Yoo S, Jolly AL, Kim S, Kim J, Baek K, Kersten RD, Fontana RJ, Sexton JZ.   +11 more
europepmc   +1 more source

Single‐Cell Mitochondrial Lineage Tracing Decodes Fate Decision and Spatial Clonal Architecture in Human Hematopoietic Organoids

Advanced Science, EarlyView.
This study repurposes mitochondrial DNA mutations as endogenous barcodes for lineage tracing in human pluripotent stem cell‐derived organoids. Integrated with transcriptomic and spatial data, it reveals NOTCH‐mediated stromal‐progenitor crosstalk orchestrates clonal dynamics and spatial zonation during early hematopoietic development, offering a non ...
Yan Xue, Junhao Su, Yiming Chao, Lu Liu, Xinyi Lin, Yang Xiang, Mun Kay Ho, Zezhuo Su, Junyi Chen, Zhuojuan Luo, Chengqi Lin, Ruibang Luo, Theo Aurich, Jianfeng Wu, Kelvin Sin Chi Cheung, Yuanhua Huang, Joshua W. K. Ho, Ryohichi Sugimura   +17 more
wiley   +1 more source

Reproducible generation of human liver organoids (HLOs) on a pillar plate platform <i>via</i> microarray 3D bioprinting. [PDF]

Lab Chip
Shrestha S, Lekkala VKR, Acharya P, Kang SY, Vanga MG, Lee MY.   +5 more
europepmc   +1 more source

Mechanical Stimuli‐Induced Manipulation of Malignant Behavior in Bioprinted Cancer Microtissues via PI3K/NF‐κB Activation

Advanced Science, EarlyView.
A mechanically tunable ECM platform is created by integrating dECM–alginate matrices with in‐bath tumor printing. The mechanically tunable ECM environment drives tumors to acquire hypoxia, mechanotransduction signaling, metastatic traits, and drug‐resistant phenotypes that collectively promote malignant transformation.
Seok‐Hyeon Lee, Jeongho Lee, Min‐Seo Choi, Minjun Ahn, Sik Yoon, Dongjun Lee, Sae‐Ock Oh, Won‐Woo Cho, Byoung Soo Kim   +8 more
wiley   +1 more source

Hepatic miR-149-5p upregulation fosters steatosis, inflammation and fibrosis development in mice and in human liver organoids. [PDF]

JHEP Rep
Correia de Sousa M, Delangre E, Berthou F, El Harane S, Maeder C, Fournier M, Krause KH, Gjorgjieva M, Foti M.   +8 more
europepmc   +1 more source