Results 241 to 250 of about 23,262 (271)
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Biomaterials
Hepatic organoids (HOs), primarily composed of hepatobiliary cells, do not represent the pathogenesis of liver diseases due to the lack of non-parenchymal cells.
Kyun Yoo Chi +14 more
semanticscholar +1 more source
Hepatic organoids (HOs), primarily composed of hepatobiliary cells, do not represent the pathogenesis of liver diseases due to the lack of non-parenchymal cells.
Kyun Yoo Chi +14 more
semanticscholar +1 more source
Hybrid Artificial Liver Using Hepatocyte Organoid Culture
Artificial Organs, 2001Abstract: We developed 2 types of hybrid artificial liver modules using hepatocyte organoid culture. One was a polyurethane foam (PUF)/hepatocyte spheroid packed‐bed module. Hepatocytes spontaneously formed spheroids in the PUF pores, and they maintained liver‐specific functions well for at least 2 weeks in vitro.
K, Funatsu +5 more
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Talanta: The International Journal of Pure and Applied Analytical Chemistry
Current genotoxicity assessment methods are mainly employed to verify the genotoxic safety of drugs, but do not allow for rapid screening of specific genotoxic impurities (GTIs). In this study, a new approach for the recognition of GTIs has been proposed.
Ying Li +14 more
semanticscholar +1 more source
Current genotoxicity assessment methods are mainly employed to verify the genotoxic safety of drugs, but do not allow for rapid screening of specific genotoxic impurities (GTIs). In this study, a new approach for the recognition of GTIs has been proposed.
Ying Li +14 more
semanticscholar +1 more source
Organoids derived from digestive tract, liver, and pancreas
Journal of Digestive Diseases, 2016Lgr5 marks stem cells in digestive epithelial tissues by lineage tracing, and in vitro ever‐expansion of Lgr5 stem cells form organoids, which can be directed to differentiate into functional somatic cells. Organoids derived from gastrointestinal epithelium even recapitulate the morphologic features of their in vivo counterpart.
An Tao, Xu, Jin Lu, Tong, Zhi Hua, Ran
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Three‐dimensional liver‐derived extracellular matrix hydrogel promotes liver organoids function
Journal of Cellular Biochemistry, 2018AbstractAn important advantage of employing extracellular matrix (ECM)‐derived biomaterials in tissue engineering is the ability to tailor the biochemical and biophysical microenvironment of the cells. This study aims to assess whether three‐dimensional (3D) liver‐derived ECM hydrogel (LEMgel) promotes physiological function of liver organoids ...
Mona Saheli +6 more
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Industrially Scalable Human Liver Organoids
2015Tissue engineering research is a multidisciplinary effort that incorporates the use of resources from various fields to address specific problems. Biomatrix scaffolds have recently been more widely used to improve the culture of cells by supporting their differentiated functions more than any known matrix extract or purified matrix component.
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Human Liver Organoids to Predict the Outcome of Kasai Portoenterostomy.
Journal of Pediatric SurgeryBACKGROUND Kasai portoenterostomy (KPE) remains the primary intervention for biliary atresia (BA), but its outcomes are highly variable. Reliable prognostic biomarkers remain elusive, complicating the management and prediction of postoperative ...
A. Wai +6 more
semanticscholar +1 more source
Organoid-guided precision hepatology for metabolic liver disease
Journal of HepatologyMetabolic dysfunction-associated steatotic liver disease affects millions of people worldwide. Progress towards a definitive cure has been incremental and treatment is currently limited to lifestyle modification. Hepatocyte-specific lipid accumulation is the main trigger of lipotoxic events, driving inflammation and fibrosis.
Sho Osonoi, Takanori Takebe
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