Results 221 to 230 of about 26,317 (246)

Liver Organoids: Formation Strategies and Biomedical Applications

Tissue Engineering and Regenerative Medicine, 2021
The liver is the most important digestive organ in the body. Several studies have explored liver biology and diseases related to the liver. However, most of these studies have only explored liver development, mechanism of liver regeneration and pathophysiology of liver diseases mainly based on two-dimensional (2D) cell lines and animal models ...
Xinglong Zhu, Bingqi Zhang, Yuting He, Ji Bao   +3 more
openaire   +2 more sources

Tissue Organoids: Liver

2017
The development of novel and consistent biologic surrogates for drug discovery, toxicology, and cancer research is presently intense and involves a growing number of research groups and institutions around the world. The Twilight of the days of immortalized cell lines as the workhorse of most of our drug development and cancer research efforts seem now
Solanas Villacampa, Estela Maria, Pla-Palacín, Iris, Sainz-Arnal, Pilar, Almeida, Manuel, Lué, Alberto, Serrano Aulló, M. Trinidad, Baptista, Pedro   +6 more
openaire   +1 more source

Ethical challenges for pediatric liver organoid transplantation

Science Translational Medicine, 2020
The authors discuss whether it is ethically acceptable to include children in a first-in-human clinical trial of liver organoid transplantation.
Sarah A. Schneemann, Sarah N. Boers, Johannes J. M. van Delden, Edward E. S. Nieuwenhuis, Sabine A. Fuchs, Annelien L. Bredenoord   +5 more
openaire   +2 more sources

Human liver organoids as in vitro models of the liver

Zeitschrift für Gastroenterologie, 2022
K. Breitkopf-Heinlein, H. Gaitantzi, E. Birgin, E. Rasbach, N. Rabahri   +4 more
openaire   +1 more source

Hydrogels derived from decellularized liver tissue support the growth and differentiation of cholangiocyte organoids

Biomaterials, 2022
Kerstin Schneeberger, Monique M A Verstegen, Luc J.W. van der Laan   +2 more
exaly  

PROLIFERATIVE LIVER ORGANOID, METABOLICCALY ACTIVATED LIVER ORGANOID, AND USE THEREOF

2021
MASUDA NORIO, SATO TOSHIRO, IGARASHI RYO
openaire   +3 more sources

Generation of Liver Organoid

2023
openaire   +1 more source

Liver sinusoidal endothelial cells promote the differentiation and survival of mouse vascularised hepatobiliary organoids

Biomaterials, 2020
George C Yeoh, Aaron M Dingle, Yi-Wen Gerrand   +2 more
exaly  

[Progress and application of liver organoids in the study of liver cancer].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
The incidence rate of liver cancer has been rising in recent years. Traditional cell line culture and human patient-derived tumor xenograft models, which are commonly used tools to simulate the occurrence of human liver cancer, have deepened the understanding of tumor occurrence, development, and drug resistance mechanisms. However, they cannot reflect
M, Wang, Z Y, Xu, C, Yu, X Y, Zhang, H Y, Cao, Y, Ma   +5 more
openaire   +1 more source

Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids

Cell Stem Cell, 2019
Benedetta Artegiani, Huili Hu, Hans Clevers   +2 more
exaly