Results 241 to 250 of about 25,342 (266)

Advances in liver organoids: model systems for liver disease

Archives of Pharmacal Research, 2022
Reliable in vitro models with human-derived cells that recapitulate in vivo-like physiologies are required for drug discovery and development to reduce the gap between the results of cell-based drug testing, animal testing, and human clinical trials. Liver organoid models have emerged as novel tools for hepatotoxicity evaluation, liver disease modeling,
Jaeseo Lee, Seon Ju Mun, Yongbo Shin
exaly   +3 more sources

Liver sinusoidal endothelial cells promote the differentiation and survival of mouse vascularised hepatobiliary organoids

Biomaterials, 2020
The structural and physiological complexity of currently available liver organoids is limited, thereby reducing their relevance for drug studies, disease modelling, and regenerative therapy.
Yi-Wen Gerrand, Aaron M Dingle, George C T Yeoh   +2 more
exaly   +2 more sources

Culture of Mouse Liver Ductal Organoids

2022
3D organoid culture has become a powerful tool and model for various human diseases, including liver diseases, such as non-alcoholic steatohepatitis (NASH). Hepatic organoids have significant advantages over traditional primary cell cultures. The hepatic progenitor cells can be induced to form hepatic organoids.
Junkai, Yan, Yunling, Tai, Huiping, Zhou
openaire   +2 more sources

Organoids for Liver Stage Malaria Research

Trends in Parasitology, 2020
Plasmodium parasites cause malaria and are maintained between Anopheles mosquitoes and mammalian hosts in a complex life cycle. Malaria parasites occupy tissue niches that can be difficult to access, and models to study them can be challenging to recapitulate experimentally, particularly for Plasmodium species that infect humans.
Ronan, Mellin, Justin A, Boddey
openaire   +2 more sources

Liver Organoids: Formation Strategies and Biomedical Applications

Tissue Engineering and Regenerative Medicine, 2021
The liver is the most important digestive organ in the body. Several studies have explored liver biology and diseases related to the liver. However, most of these studies have only explored liver development, mechanism of liver regeneration and pathophysiology of liver diseases mainly based on two-dimensional (2D) cell lines and animal models ...
Xinglong Zhu, Bingqi Zhang, Yuting He, Ji Bao   +3 more
openaire   +2 more sources

Cellulose Nanofibril Hydrogel Promotes Hepatic Differentiation of Human Liver Organoids [PDF]

Advanced Healthcare Materials, 2020
To replicate functional liver tissue in vitro for drug testing or transplantation, 3D tissue engineering requires representative cell models as well as scaffolds that not only promote tissue production but also are applicable in a clinical setting ...
Melanie Kruger, Loes A Oosterhoff, Monique E Van Wolferen   +2 more
exaly   +2 more sources

Tissue Organoids: Liver

2017
The development of novel and consistent biologic surrogates for drug discovery, toxicology, and cancer research is presently intense and involves a growing number of research groups and institutions around the world. The Twilight of the days of immortalized cell lines as the workhorse of most of our drug development and cancer research efforts seem now
Solanas Villacampa, Estela Maria, Pla-Palacín, Iris, Sainz-Arnal, Pilar, Almeida, Manuel, Lué, Alberto, Serrano Aulló, M. Trinidad, Baptista, Pedro   +6 more
openaire   +1 more source

Ethical challenges for pediatric liver organoid transplantation

Science Translational Medicine, 2020
The authors discuss whether it is ethically acceptable to include children in a first-in-human clinical trial of liver organoid transplantation.
Sarah A. Schneemann, Sarah N. Boers, Johannes J. M. van Delden, Edward E. S. Nieuwenhuis, Sabine A. Fuchs, Annelien L. Bredenoord   +5 more
openaire   +2 more sources

3D multi-cell-type liver organoids: A new model of non-alcoholic fatty liver disease for drug safety assessments

Toxicology in Vitro
International audienceThe development of in vitro models that recapitulate critical liver functions is essential for accurate assessments of drug toxicity.
Bronsard, J., Clement, B., Corlu, A., Fromenty, B., Catheline, Daniel, D., Savary, C., Rioux, V., Massart, J., Viel, R., Moutaux, L., Ferron, P.J.   +10 more
exaly   +2 more sources

Human liver organoids as in vitro models of the liver

Zeitschrift für Gastroenterologie, 2022
K. Breitkopf-Heinlein, H. Gaitantzi, E. Birgin, E. Rasbach, N. Rabahri   +4 more
openaire   +1 more source