Results 211 to 220 of about 26,317 (246)

Reversal of ACLF and ALF using whole blood extracorporeal system combining HLA-depleted liver organoids with granulocyte-monocyte apheresis. [PDF]

J Hepatol
Yamaguchi H, Yoneyama Y, Ichimura K, Ohtsu K, Soen M, Moriya C, Kumagai M, Myers RP, Subramanian GM, Takebe T.   +9 more
europepmc   +1 more source

Liver organoids: updates on generation strategies and biomedical applications. [PDF]

Stem Cell Res Ther
Liu S, Cheng C, Zhu L, Zhao T, Wang Z, Yi X, Yan F, Wang X, Li C, Cui T, Yang B.   +10 more
europepmc   +1 more source

Current hPSC-derived liver organoids for toxicity testing: Cytochrome P450 enzymes and drug metabolism. [PDF]

Toxicol Res
Kim H, Park HJ.
europepmc   +1 more source

Human iPSC-derived liver organoids model multicellular tissue responses and therapeutic rescue in Wolman disease

Selvestrel D, Da Rodda C, Anfuso B, Laurent M, Antona A, Mattivi A, Velnati S, Hofmann K, Conti L, Bonazza D, Zanconati F, Mastronardi M, De Manzini N, Rosso N, Bertolio R, Marfoglia A, Tiribelli C, Manfredi M, Capello D, Drabent P, Fava LL, Palmisano S, Del Sal G, Amendola M, Sorrentino G.   +24 more
europepmc   +1 more source

Novel hepatocyte-like liver organoids recapitulate crucial mature hepatic functions

Ardisasmita AI, Joore IP, Levy N, Myszczyszyn A, Marsee A, Sinnige T, Ruiter J, Ferdinandusse S, Dudaryeva O, Gruber E, Daive V, Levato R, Spee B, Verstegen M, van der Laan L, Nieuwenhuis EES, Schene IF, Fuchs SA.   +17 more
europepmc   +1 more source

Organoids to model liver disease [PDF]

JHEP Reports, 2021
The organoid model represents a major breakthrough in cell biology that has revolutionised biomedical research. Organoids are 3D physiological in vitro structures that recapitulate morphological and functional features of in vivo tissues and offer significant advantages over traditional cell culture methods.
Sandro Nuciforo, Markus H Heim
exaly   +4 more sources

Liver Organoids, Novel and Promising Modalities for Exploring and Repairing Liver Injury

Stem Cell Reviews and Reports, 2022
The past decades have witnessed great advances in organoid technology. Liver is the biggest solid organ, performing multifaceted physiological functions. Nowadays, liver organoids have been applied in many fields including pharmaceutical research, precision medicine and disease models. Compared to traditional 2-dimensional cell line cultures and animal
Xiao Xu, Di Lu, Modan Yang
exaly   +5 more sources

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Advances in liver organoids: model systems for liver disease

Archives of Pharmacal Research, 2022
Reliable in vitro models with human-derived cells that recapitulate in vivo-like physiologies are required for drug discovery and development to reduce the gap between the results of cell-based drug testing, animal testing, and human clinical trials. Liver organoid models have emerged as novel tools for hepatotoxicity evaluation, liver disease modeling,
Jaeseo Lee, Seon Ju Mun, Yongbo Shin, Seonbhin Lee, Myung Jin Son   +4 more
openaire   +2 more sources

Culture of Mouse Liver Ductal Organoids

2022
3D organoid culture has become a powerful tool and model for various human diseases, including liver diseases, such as non-alcoholic steatohepatitis (NASH). Hepatic organoids have significant advantages over traditional primary cell cultures. The hepatic progenitor cells can be induced to form hepatic organoids.
Junkai, Yan, Yunling, Tai, Huiping, Zhou
openaire   +2 more sources

Organoids for Liver Stage Malaria Research

Trends in Parasitology, 2020
Plasmodium parasites cause malaria and are maintained between Anopheles mosquitoes and mammalian hosts in a complex life cycle. Malaria parasites occupy tissue niches that can be difficult to access, and models to study them can be challenging to recapitulate experimentally, particularly for Plasmodium species that infect humans.
Ronan, Mellin, Justin A, Boddey
openaire   +2 more sources