Results 211 to 220 of about 24,091 (241)
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Advances in liver organoids: model systems for liver disease
Archives of Pharmacal Research, 2022Reliable in vitro models with human-derived cells that recapitulate in vivo-like physiologies are required for drug discovery and development to reduce the gap between the results of cell-based drug testing, animal testing, and human clinical trials. Liver organoid models have emerged as novel tools for hepatotoxicity evaluation, liver disease modeling,
Myung Jin Son, Seon Ju Mun, Jaeseo Lee
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Liver Organoids, Novel and Promising Modalities for Exploring and Repairing Liver Injury
Stem Cell Reviews and Reports, 2022 The past decades have witnessed great advances in organoid technology. Liver is the biggest solid organ, performing multifaceted physiological functions. Nowadays, liver organoids have been applied in many fields including pharmaceutical research, precision medicine and disease models. Compared to traditional 2-dimensional cell line cultures and animal
Xiao Xu, Di Lu, Modan Yang
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Culture of Mouse Liver Ductal Organoids
20223D organoid culture has become a powerful tool and model for various human diseases, including liver diseases, such as non-alcoholic steatohepatitis (NASH). Hepatic organoids have significant advantages over traditional primary cell cultures. The hepatic progenitor cells can be induced to form hepatic organoids.
Junkai, Yan, Yunling, Tai, Huiping, Zhou
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Organoids for Liver Stage Malaria Research
Trends in Parasitology, 2020Plasmodium parasites cause malaria and are maintained between Anopheles mosquitoes and mammalian hosts in a complex life cycle. Malaria parasites occupy tissue niches that can be difficult to access, and models to study them can be challenging to recapitulate experimentally, particularly for Plasmodium species that infect humans.
Ronan, Mellin, Justin A, Boddey
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Liver Organoids: Formation Strategies and Biomedical Applications
Tissue Engineering and Regenerative Medicine, 2021The liver is the most important digestive organ in the body. Several studies have explored liver biology and diseases related to the liver. However, most of these studies have only explored liver development, mechanism of liver regeneration and pathophysiology of liver diseases mainly based on two-dimensional (2D) cell lines and animal models ...
Xinglong Zhu +3 more
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2017
The development of novel and consistent biologic surrogates for drug discovery, toxicology, and cancer research is presently intense and involves a growing number of research groups and institutions around the world. The Twilight of the days of immortalized cell lines as the workhorse of most of our drug development and cancer research efforts seem now
Solanas Villacampa, Estela Maria +6 more
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The development of novel and consistent biologic surrogates for drug discovery, toxicology, and cancer research is presently intense and involves a growing number of research groups and institutions around the world. The Twilight of the days of immortalized cell lines as the workhorse of most of our drug development and cancer research efforts seem now
Solanas Villacampa, Estela Maria +6 more
openaire +1 more source
Ethical challenges for pediatric liver organoid transplantation
Science Translational Medicine, 2020The authors discuss whether it is ethically acceptable to include children in a first-in-human clinical trial of liver organoid transplantation.
Sarah A. Schneemann +5 more
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Human liver organoids as in vitro models of the liver
Zeitschrift für Gastroenterologie, 2022K. Breitkopf-Heinlein +4 more
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PROLIFERATIVE LIVER ORGANOID, METABOLICCALY ACTIVATED LIVER ORGANOID, AND USE THEREOF
2021MASUDA NORIO, SATO TOSHIRO, IGARASHI RYO
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The Potential Clinical Use of Stem/Progenitor Cells and Organoids in Liver Diseases
Cells, 2022Maria G Roubelakis, Roubelakis Maria G
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