Results 81 to 90 of about 35,405 (287)
An individual based computational model of intestinal crypt fission and its application to predicting unrestrictive growth of the intestinal epithelium. [PDF]
, 2014 Intestinal crypt fission is a homeostatic phenomenon, observable in healthy adult mucosa, but which also plays a pathological role as the main mode of growth of some intestinal polyps.A. Patrick Gunning, Aimee Parker, Andreu, Arber, Barker, Barker, Bashir, Berlanga-Acosta, Buczacki, Buske, Buske, Cairnie, Carmen Pin, Cheng, Cheng, Clarke, Clevers, Cummins, Cummins, Dehmer, Dekaney, Drasdo, Drasdo, Dunn, Durand, Edwards, Fauser, Galle, Hannezo, Haramis, Hirata, Humphries, Humphries, Hutter, Ian T. Johnson, Leushacke, Li, Li, Loeffler, Loeffler, Loeffler, Loeffler, Meineke, Milicic, Miyoshi, Nelson, Nelson, Ootani, Osborne, Pin, Pitt-Francis, Potten, Roth, Rothenberg, Sato, Sato, Sato, Sato, Simon R. Carding, Snippert, St Clair, Toshiro Sato, Totafurno, van Es, Wasan, Wong, Wright, Wright, Wright, Yuki Ohta +69 morecore +1 more sourceDeveloping evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking +43 morewiley +1 more sourceTargeting colorectal cancer via its microenvironment by inhibiting IGF-1 receptor-insulin receptor substrate and STAT3 signaling. [PDF]
, 2016 The tumor microenvironment (TME) exerts critical pro-tumorigenic effects through cytokines and growth factors that support cancer cell proliferation, survival, motility and invasion.Flashner-Abramson, E, Karin, M, Levitzki, A, Sanchez-Lopez, E, Shalapour, S, Taniguchi, K, Zhong, Z +6 morecore +1 more sourceLDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber +13 morewiley +1 more sourceBioengineering thymus organoids to restore thymic function and induce donor-specific immune tolerance to allografts [PDF]
, 2015 One of the major obstacles in organ transplantation is to establish immune tolerance of allografts. Although immunosuppressive drugs can prevent graft rejection to a certain degree, their efficacies are limited, transient, and associated with severe side Alpdogan, Anderson, Anderson, Antonina Coppola, Asako Tajima, Bennett, Bleul, Boehm, Bonfanti, Bonner, Bredenkamp, Bredenkamp, Calderón, Chu, Chung, Corbeaux, De Barros, Depreter, Dudakov, Erickson, Falcon, Fan, Fan, Fan, Fink, Fletcher, Flomerfelt, Foss, Gilbert, Gill, Giulio Gualtierotti, Goh, Goh, Gottrand, Heng, Hogquist, Hsu, Inami, Ipsita Banerjee, Jin, Kermani, Klein, Komori, Krell, Macchiarini, Mali, Manley, Maria Grupillo, Marshall, Massimo Trucco, Mathis, Min, Nitta, Orlando, Ott, Ott, Parent, Petersen, Pinto, Posselt, Poznansky, Quah, Rae, Rita Bottino, Saik Kia Goh, Schechner, Seach, Seach, Shin’oka, Sjöqvist, Song, Sun, Suzanne Bertera, Takada, Thornton, Uygun, van Ewijk, Wekerle, William A Rudert, Wong, Xuehui Geng, Yong Fan, Zartman +82 morecore +1 more sourceGenetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova +25 morewiley +1 more sourcePU.1 controls fibroblast polarization and tissue fibrosis [PDF]
, 2019 Fibroblasts are polymorphic cells with pleiotropic roles in organ morphogenesis, tissue homeostasis and immune responses. In fibrotic diseases, fibroblasts synthesize abundant amounts of extracellular matrix, which induces scarring and organ failure.Beyer, Christian, Boykin, David W., Butter, Falk, Chen, Chih-Wei, Daniel, Christoph, Dees, Clara, Distler, Jörg H. W., Distler, Oliver, Ekici, Arif, Finotto, Susetta, Gay, Steffen, Gelse, Kolja, Jüngel, Astrid, Kaplan, Mark H., Karouzakis, Emmanuel, Kiener, Hans P., Kremer, Andreas E., Kreuter, Alexander, Luber, Markus, Maier, Christiane, Matei, Alexandru-Emil, Naschberger, Elisabeth, Nutt, Stephen L., Pachera, Elena, Poon, Gregory M. K., Ramming, Andreas, Rauber, Simon, Schett, Georg, Soare, Alina, Sticherling, Michael, Stürzl, Michael, Uebe, Steffen, Weber, Stefanie, Wohlfahrt, Thomas +33 morecore +1 more sourceImpact of sitagliptin on endometrial mesenchymal stem-like progenitor cells : a randomised, double-blind placebo-controlled feasibility trial [PDF]
, 2020 Background:
Recurrent pregnancy loss (RPL) is associated with the loss of endometrial mesenchymal stem-like progenitor cells (eMSC). DPP4 inhibitors may increase homing and engraftment of bone marrow-derived cells to sites of tissue injury.Brighton, Paul (Paul J.), Brosens, Jan J., Da Costa, Maria José Minhoto Diniz, Ewington, Lauren J., Fishwick, Katherine, Fujihara, Risa, Kimani, Peter K., Lacey, Lauren, Lucas, Emma S., Muter, Joanne, Polanco, Angela, Quenby, Siobhan, Takeda, Satoru, Tewary, Shreeya +13 morecore +1 more sourceA 3D Biofabricated Disease Model Mimicking the Brain Extracellular Matrix Suitable to Characterize Intrinsic Neuronal Network Alterations in the Presence of a Breast Tumor Disseminated to the Brain
Advanced Functional Materials, EarlyView.A 3D disease model is developed using customized hyaluronic‐acid‐based hydrogels supplemented with extracellular matrix (ECM) proteins resembling brain ECM properties. Neurons, astrocytes, and tumor cells are used to mimic the native brain surrounding.Esra Türker, Mateo S. Andrade Mier, Jessica Faber, Mike Friedrich, Zan Lamberger, Jeannette Weigelt, Christian Stigloher, Nicoletta Murenu, Natascha Schaefer, Jörg Tessmar, Gregor Lang, Silvia Budday, Katrin G. Heinze, Antje Appelt‐Menzel, Pamela L. Strissel, Reiner Strick, Carmen Villmann +16 morewiley +1 more sourceLiver ‘organ on a chip’ [PDF]
, 2018 © 2017 The liver plays critical roles in both homeostasis and pathology. It is the major site of drug metabolism in the body and, as such, a common target for drug-induced toxicity and is susceptible to a wide range of diseases.Beckwitt, Colin H., Clark, Amanda M., Griffith, Linda G, Stolz, Donna B., Taylor, D. Lansing, Wells, Alan, Wheeler, Sarah +6 morecore +1 more source
