Results 1 to 10 of about 431,385 (241)
Natural Products Targeting Liver X Receptors or Farnesoid X Receptor [PDF]
Frontiers in Pharmacology, 2022 Nuclear receptors (NRs) are a superfamily of transcription factors induced by ligands and also function as integrators of hormonal and nutritional signals.
Jianglian She +9 more
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Liver X receptor agonist T0901317 alleviates sepsis-induced acute lung injury by enhancing macrophage autophagy [PDF]
Frontiers in PharmacologyBackgroundThis study was aimed at identifying the effects of liver X receptor alpha (LXRα) on sepsis-induced acute lung injury (ALI) and clarifying its novel regulatory mechanisms using bioinformatics and experimental methods.MethodsBioinformatics ...
Ben Wang +6 more
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Dietary Phenolic Compounds Exert Some of Their Health-Promoting Bioactivities by Targeting Liver X Receptor (LXR) and Retinoid X Receptor (RXR) [PDF]
Foods, 2023 Consuming foods of vegetable origin has been shown to exert multiple health-related effects, many of them attributed to their phenolic compounds. These molecules are known for being bioactive across multiple cells and organs, with documented changes in ...
J. Abraham Domínguez-Avila
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The liver X receptor agonist LXR 623 restricts flavivirus replication [PDF]
Emerging Microbes and Infections, 2021 The vector-borne flaviviruses (VBFVs) are well known for causing great misery and death in humans worldwide. The VBFVs include those transmitted by mosquitos, such as Zika virus (ZIKV), dengue virus; and those transmitted by ticks including the tick ...
Luwanika Mlera +6 more
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Liver X receptors and immune regulation
Biomolecular Concepts, 2010 Recent studies suggest that homeostasis of lipid metabolism is crucial for the function of various immune cells. Oxygenated derivatives of cholesterol (oxysterols) are well-known regulators of lipid metabolism and have diverse functions, such as ...
Nunomura Satoshi +2 more
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Development of Agonist-Based PROTACs Targeting Liver X Receptor
Frontiers in Chemistry, 2021 Liver X receptors (LXRs) belong to the nuclear hormone receptor superfamily and function as ligand-dependent transcription factors that regulate cholesterol homeostasis, lipid homeostasis, and immune responses.
Hanqiao Xu +11 more
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Frontiers in Pharmacology, 2023 Introduction: Non-alcoholic fatty liver disease (NAFLD) incidence has been rapidly increasing, and it has emerged as one of the major diseases of the modern world.
Varsha D. Shiragannavar +8 more
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Role of Liver X Receptor in AD Pathophysiology. [PDF]
PLoS ONE, 2015 Alzheimer's disease (AD) is the major cause of dementia worldwide. The pharmacological activation of nuclear receptors (Liver X receptors: LXRs or Retinoid X receptors: RXR) has been shown to induce overexpression of the ATP-Binding Cassette A1 (ABCA1 ...
Adrián G Sandoval-Hernández +4 more
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Journal of Integrative Neuroscience, 2021 The disorder of lipid metabolism, especially cholesterol metabolism, can promote Alzheimer’s Disease. Curcumin can ameliorate lipid metabolic disorder in the brain of Alzheimer’s Disease patients, while the mechanism is not clear.
Mingyuan Tian +6 more
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Liver X receptor in cholesterol metabolism [PDF]
Journal of Endocrinology, 2009 The liver X receptors (LXRs) are nuclear receptors that are activated by endogenous oxysterols, oxidized derivatives of cholesterol. There are two isoforms of LXR, LXRα (NR1H3) and LXRβ (NR1H2). Both LXRα and LXRβ regulate gene expression by binding to DNA sequences associated with target genes as heterodimers with isoforms of the retinoid X receptor ...
Chunyan, Zhao, Karin, Dahlman-Wright
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