Results 11 to 20 of about 431,385 (241)
LXRs: The Key Regulators of Intermediary Metabolism in Metabolic Syndrome [PDF]
Reviews in Clinical Medicine, 2017 Metabolic syndrome and its various manifestations are considered to be a significant health epidemic in the developed and developing countries across the world.
Hassan Mehrad-Majd +2 more
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Inflammation Triggers Liver X Receptor-Dependent Lipogenesis [PDF]
Molecular and Cellular Biology, 2020 Immune cell function can be modulated by changes in lipid metabolism. Our studies indicate that cholesterol and fatty acid synthesis increases in macrophages between 12 and 18 h after the activation of Toll-like receptors with proinflammatory stimuli and that the upregulation of lipogenesis may contribute to the resolution of inflammation.
Sophie R. Liebergall +7 more
openaire +2 more sources
Journal of Lipid Research, 2013 Long-chain acyl-CoA synthetases (ACSL) play key roles in fatty acid metabolism in liver and other metabolic tissues in an isozyme-specific manner. In this study, we examined the effects of a fructose-enriched diet on expressions of ACSL isoforms in the ...
Bin Dong +3 more
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Phosphorylation of the liver X receptors [PDF]
FEBS Letters, 2006 The liver X receptors (LXRs) function as nutritional sensors for cholesterol and have important roles in lipid metabolism, glucose homeostasis, and inflammation. We provide the first evidence that LXRs are phosphorylated proteins. Mutational analysis and metabolic labeling indicate LXRα is phosphorylated on serine 198 in the hinge region.
Chen, Mingyi +3 more
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Journal of Pharmacological Sciences, 2005 Nuclear receptors are ligand-dependent transcription factors that recently have been shown to play important roles in the metabolism of cholesterol and bile acids.
Makoto Makishima
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Liver X Receptors and Male (In)fertility [PDF]
International Journal of Molecular Sciences, 2019 Liver X receptors (LXRs) are ligand-dependent transcription factors acting as ‘cholesterol sensors’ to regulate lipid homeostasis in cells. The two isoforms, LXRα (NR1H3) and LXRβ (NR1H2), are differentially expressed, with the former expressed predominantly in metabolically active tissues and the latter more ubiquitously.
Sheba Jarvis +2 more
openaire +4 more sources
Journal of Pharmacy & Pharmaceutical Sciences, 2012 Purpose. Intestinal ischemia-reperfusion (I/R) damages remote organs, including the liver, and promotes multi-organ failure (MOF). However, the molecular mechanisms underlying acute liver injury after intestinal I/R have not been completely elucidated ...
Jiro Ogura +13 more
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Farnesoid X receptor, the bile acid sensing nuclear receptor, in liver regeneration
Acta Pharmaceutica Sinica B, 2015 The liver is unique in regenerative potential, which could recover the lost mass and function after injury from ischemia and resection. The underlying molecular mechanisms of liver regeneration have been extensively studied in the past using the partial ...
Guodong Li, Grace L. Guo
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Peroxisome Proliferator-Activated Receptor and Retinoic X Receptor in Alcoholic Liver Disease
PPAR Research, 2009 A growing number of new studies demonstrate that nuclear receptors are involved in the development of alcoholic liver disease (ALD). Ethanol metabolism and RXR/PPAR functions are tightly interconnected in the liver.
Tommaso Mello +2 more
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Liver X receptor activation promotes differentiation of regulatory T cells. [PDF]
PLoS ONE, 2017 The nuclear receptor Liver X Receptor (LXR) is a ligand-activated transcription factor that has been implicated in control of chronic inflammation by downregulating pro-inflammatory T cell responses.
Martin Herold +6 more
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