Results 271 to 280 of about 792,189 (305)
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The Liver X Receptor and Atherosclerosis
New England Journal of Medicine, 2007Atherosclerosis can be prevented in mice by treating them with a ligand of the liver X receptor β, a protein expressed by macrophages.
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Liver X Receptors, Atherosclerosis and Inflammation
Current Atherosclerosis Reports, 2012Liver X receptors (LXRs) belong to the nuclear receptor superfamily of ligand-dependent transcription factors. LXRs are activated by oxysterols, metabolites of cholesterol, and therefore act as intracellular sensors of this lipid. There are two LXR genes (α and β) that display distinct tissue/cell expression profiles.
Daryn R, Michael +3 more
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Liver X Receptor and Farnesoid X Receptor as Therapeutic Targets
The American Journal of Cardiology, 2007Despite the success of existing therapies, new therapies targeted toward dyslipidemia are still needed. Liver X receptor (LXR) and farnesoid X receptor (FXR) represent 2 very different attractive targets for new therapeutic development. LXR is a nuclear receptor that primarily acts to rid cells and the body of excess cholesterol. LXR agonists have been
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Liver X receptor: from metabolism to cancer
Biochemical Journal, 2014Cholesterol plays an indispensable role in regulating the properties of cell membranes in mammalian cells. Accumulation of cholesterol and its intermediates, such as oxysterols, lead to activation of the nuclear receptors LXRs (liver X receptors).
Nicolas, Venteclef, Pascal, Ferré
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Targeting liver X receptors in cancer therapeutics
Nature Reviews Cancer, 2015Members of the nuclear receptor superfamily of ligand-dependent transcription factors carry out vital cellular functions and are highly druggable therapeutic targets. Liver X receptors (LXRs) are nuclear receptor family members that function in cholesterol transport, glucose metabolism and the modulation of inflammatory responses.
Chin-Yo, Lin, Jan-Åke, Gustafsson
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Liver X receptors in cardiovascular and metabolic disease
Cellular and Molecular Life Sciences, 2006Liver X receptors (LXRs) alpha and beta are nuclear oxysterol receptors and metabolic sensors initially found to regulate cholesterol metabolism and lipid biosynthesis. Recent studies have elucidated the importance of LXR in the development of cardiovascular diseases and metabolic disorders.
R, Geyeregger, M, Zeyda, T M, Stulnig
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Natural modulators of liver X receptors
Journal of Integrative Medicine, 2014Nuclear receptor transcription factors are ligand-activated proteins that control various biological events from cell growth and development to lipid metabolism, and energy and glucose homeostasis. Nuclear receptors are important drug targets for metabolic diseases. Liver X receptors (LXRs) are nuclear receptor transcription factors that play essential
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Regulation of cholesterol homeostasis by liver X receptors
Clinica Chimica Acta, 2010Cellular cholesterol levels reflect a balance between uptake, efflux, and endogenous synthesis. The sterol-responsive transcription factors liver X receptors (LXRalpha and LXRbeta) help maintain cholesterol homeostasis, not only through promotion of cholesterol efflux from peripheral tissues but also through suppression of de novo synthesis and ...
Yan-Wei, Hu, Lei, Zheng, Qian, Wang
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Cardiology in Review, 2010
Liver X receptors (LXRs) are nuclear receptors that play a major role in the expression of genes which are involved in lipid metabolism. LXRs are part of the superfamily of steroid receptors that work to deliver metabolic signals on the transcriptional level to either suppress or activate target genes.
Neil, Parikh, William H, Frishman
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Liver X receptors (LXRs) are nuclear receptors that play a major role in the expression of genes which are involved in lipid metabolism. LXRs are part of the superfamily of steroid receptors that work to deliver metabolic signals on the transcriptional level to either suppress or activate target genes.
Neil, Parikh, William H, Frishman
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Xol INXS: role of the liver X and the farnesol X receptors
Current Opinion in Lipidology, 2001Cholesterol and bile acid metabolism is tightly controlled by nuclear receptors. The liver X receptor, an oxysterol-activated nuclear receptor, limits cholesterol accumulation in the body both by stimulating reverse cholesterol transport and by inhibiting intestinal cholesterol absorption.
Fayard, Elisabeth +2 more
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