Results 281 to 290 of about 792,189 (305)

A Natural Product Ligand of the Oxysterol Receptor, Liver X Receptor

The Journal of Pharmacology and Experimental Therapeutics, 2003
Natural products have been identified as ligands for a number of members of the nuclear hormone receptor (NHR) superfamily. Often these natural products are used as dietary supplements to treat myriad ailments ranging from perimenopausal hot flashes to hypercholesterolemia and reduced cognitive function.
Kelli S, Bramlett, Keith A, Houck, Kristen M, Borchert, Michele S, Dowless, Palaniappan, Kulanthaivel, Youyan, Zhang, Thomas P, Beyer, Robert, Schmidt, Jeffrey S, Thomas, Laura F, Michael, Robert, Barr, Chahrzad, Montrose, Patrick I, Eacho, Guoqing, Cao, Thomas P, Burris   +14 more
openaire   +2 more sources

The liver X receptors.

Current opinion in investigational drugs (London, England : 2000), 2005
The liver X receptors (LXRs), members of the nuclear receptor superfamily, are potential targets for a variety of diseases. While there are many opportunities for the development of LXR-based therapeutics, there are some major hurdles, such as the ability of LXRs to cause hypertriglyceridemia, as well as some species-dependent aspects of LXR-mediated ...
openaire   +1 more source

Paeoniflorin acts as a liver X receptor agonist

Journal of Asian Natural Products Research, 2013
Paeoniflorin is one of the active ingredients of Paeonia lactiflora Pall., a novel traditional herbal medicine exerting pharmacological effects including antihyperlipidemic, neuroprotective, and anti-hepatofibrosis effects. Liver X receptor (LXR) acts as a ligand-activated transcription factor to exhibit antihyperlipidemic and neuroprotective effects ...
openaire   +2 more sources

Liver X Receptors

Current Medicinal Chemistry-Immunology, Endocrine & Metabolic Agents, 2002
Xiao Hu, Deepak Lala
openaire   +1 more source

Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Özge Gumusay, Damé Idossa   +2 more
exaly  

Liver X receptors and atherosclerosis.

IDrugs : the investigational drugs journal, 2004
Cardiovascular disease, the primary cause of death and illness in the industrialized world, is typically due to complications of atherosclerosis, a multifactorial disease of the arterial intima. The liver X receptors (LXRs), LXRalpha and LXRbeta, are intracellular receptors that appear to play an important role in protection against atherosclerosis ...
openaire   +1 more source

The Nuclear Receptor PXR in Chronic Liver Disease

Cells, 2022
Francesco Paolo Russo, Daniela Gabbia, Sara de Martin   +2 more
exaly  

Disparities in liver cancer occurrence in the United States by race/ethnicity and state

Ca-A Cancer Journal for Clinicians, 2017
Farhad Islami, Kimberly D Miller, Rebecca L Siegel   +2 more
exaly  

Role of farnesoid X receptor and bile acids in alcoholic liver disease

Acta Pharmaceutica Sinica B, 2015
Sharon Manley
exaly  

Major histocompatibility complex class I related molecules control the development of CD4+8- and CD4-8- subsets of natural killer 1.1+ T cell receptor-alpha/beta+ cells in the liver of mice.

Journal of Experimental Medicine, 1994
Toshiaki Ohteki, H R MacDonald
exaly