Results 1 to 10 of about 188,786 (131)

LL-37 and citrullinated-LL-37 enhances oxylipins: citrullination attenuates LL-37-mediated COX-2-dependent chemokine response in human bronchial epithelial cells [PDF]

Respiratory Research
Background During airway inflammation, chemokines, oxylipins (bioactive lipids) and cationic host defence peptides (CHDP) are enhanced in the lungs. However, the interplay of these molecules in the process of airway inflammation is not fully resolved ...
Padmanie Ramotar, Mahadevappa Hemshekhar, Anthony Altieri, Anne M van der Does, Christopher D Pascoe, Neeloffer Mookherjee   +5 more
doaj   +2 more sources

Serum LL‐37 and inflammatory cytokines levels in psoriasis [PDF]

Immunity, Inflammation and Disease, 2023
Background Psoriasis (PsO) is a T‐cell‐associated inflammatory autoimmune dermatitis. Leucine leucine‐37 (LL‐37) is upregulated in PsO patients and correlated with the area and severity of PsO.
Juanfeng Lao, Zhi Xie, Qunshi Qin, Ru Qin, Shangyang Li, Yulin Yuan   +5 more
doaj   +2 more sources

Elevated LL-37/FPR2 Axis and its Regulatory Role for Gingival Fibroblasts in Periodontitis [PDF]

International Dental Journal
Introduction and aims: LL-37, an antimicrobial peptide with dual pro-/anti-inflammatory roles, has been implicated in the pathogenesis of periodontitis, yet its specific action through its receptor Formyl peptide receptor 2 (FPR2) remains unclear.
Tingting Lin, Zhurong Cui, Yue Shen, Ruhan Yang, Weijun Yu, Shucheng Hu, Yuanjie Shi, Bin Jiang, Min Jin, Eryi Lu, Yuting Gu   +10 more
doaj   +2 more sources

LL-37 and citrullinated-LL-37 modulate IL-17A/F-mediated responses and selectively suppress Lipocalin-2 in bronchial epithelial cells [PDF]

Journal of Inflammation
Background Levels of the human cationic antimicrobial host defence peptide LL-37 are enhanced in the lungs during neutrophilic airway inflammation. LL-37 drives Th17 differentiation, and Th17 cells produce IL-17A and IL-17F which form the biologically ...
Anthony Altieri, Dylan Lloyd, Padmanie Ramotar, Anne M van der Does, Mahadevappa Hemshekhar, Neeloffer Mookherjee   +5 more
doaj   +2 more sources

Glioblastoma Multiforme: Sensitivity to Antimicrobial Peptides LL-37 and PG-1, and Their Combination with Chemotherapy for Predicting the Overall Survival of Patients [PDF]

Pharmaceutics
Background/Objectives: Glioblastomas (GBMs) are the most malignant and intractable of all cancers, with an unfavorable clinical prognosis for affected patients. The objective was to analyze the sensitivity of GBM cells to the antimicrobial peptides (AMPs)
Alexander N. Chernov, Sofia S. Skliar, Alexander V. Kim, Anna Tsapieva, Sarng S. Pyurveev, Tatiana A. Filatenkova, Marina V. Matsko, Sergey D. Ivanov, Olga V. Shamova, Alexander N. Suvorov   +9 more
doaj   +2 more sources

Evaluation of the ability of LL-37 to neutralise LPS in vitro and ex vivo. [PDF]

PLoS ONE, 2011
BackgroundHuman cathelicidin LL-37 is a cationic antimicrobial peptide (AMP) which possesses a variety of activities including the ability to neutralise endotoxin. In this study, we investigated the role of LPS neutralisation in mediating LL-37's ability
Aaron Scott, Sinéad Weldon, Paul J Buchanan, Bettina Schock, Robert K Ernst, Danny F McAuley, Michael M Tunney, Chris R Irwin, J Stuart Elborn, Clifford C Taggart   +9 more
doaj   +5 more sources

Identifying the Critical Domain of LL-37 Involved in Mediating Neutrophil Activation in the Presence of Influenza Virus: Functional and Structural Analysis. [PDF]

PLoS ONE, 2015
The human cathelicidin LL-37 has been shown to play a role in host defense against influenza A viruses (IAV) through direct antiviral effects and through modulating inflammatory responses to infection.
Shweta Tripathi, Guangshun Wang, Mitchell White, Michael Rynkiewicz, Barbara Seaton, Kevan Hartshorn   +5 more
doaj   +6 more sources

A Novel Pathway of Platelet Activation in ACS Mediated by LL-37 Immunoglobulin G Autoantibody Immune Complexes [PDF]

JACC: Basic to Translational Science
Summary: The cathelicidin antimicrobial peptide LL-37 is a self-antigen in neutrophil extracellular traps that provokes autoantibody responses in autoimmune/autoinflammatory conditions.
Paul C. Dimayuga, PhD, Kuang-Yuh Chyu, MD, PhD, Xiaoning Zhao, PhD, Jianchang Zhou, PhD, Nicole Wai Man Lio, BS, Fernando Chernomordik, MD, Daniel Berman, MD, Prediman K. Shah, MD, Bojan Cercek, MD, PhD   +8 more
doaj   +2 more sources

The antibacterial effect of human adipose-derived stem cells on LL-37-resistant bacteria. [PDF]

PLoS ONE
Human adipose-derived stem cells (hADSCs) exhibit antibacterial properties, but their effectiveness against bacteria resistant to LL-37- a natural human antimicrobial peptide important in the immune defense- is not fully understood.
Parisa Afzal Haghjoo, Ali Mojtahedi, Malek Moien Ansar, Malek Masoud Ansar, Safieh Danesh Mobarhan   +4 more
doaj   +2 more sources

LL-37 Attenuates Sepsis-Induced Lung Injury by Alleviating Inflammatory Response and Epithelial Cell Oxidative Injury via ZBP1-Mediated Autophagy [PDF]

Toxins
Background: Sepsis-induced acute lung injury (ALI) is a serious disease constituting a heavy burden on society due to high mortality and morbidity. Inflammation and oxidative stress constitute key pathological mechanisms in ALI caused by sepsis.
Hu Gao, Fajuan Tang, Bin Chen, Xihong Li
doaj   +2 more sources