Results 31 to 40 of about 188,935 (276)
Biochemistry and Biophysics Reports, 2022 The human antimicrobial peptide LL-37 permeabilizes the plasma membrane of host cells, but LL-37-induced direct effects on mitochondrial membrane permeability and function has not been reported.
Elisabeth Bankell +6 more
doaj +1 more source
Antimicrobial peptides and eicosanoids : roles and interactions in inflammation and host defense [PDF]
, 2017 Antimicrobial peptides (AMPs) have a broad spectrum of activities and exert their functions by both direct killing of microbes through the interaction with the microbial membrane, and modulation of innate and adaptive immunity of the host.
Tang, Xiao
core +1 more source
The Antimicrobial Peptide, LL-37, Inhibits in vitro Osteoclastogenesis [PDF]
Journal of Dental Research, 2012 Uncoupled bone resorption leads to net alveolar bone loss in periodontitis. The deficiency of LL-37, the only human antimicrobial peptide in the cathelicidin family, in patients with aggressive periodontitis suggests that LL-37 may play a pivotal role in the inhibition of alveolar bone destruction in periodontitis.
Supanchart, C. +6 more
openaire +6 more sources
LL-37 boosts immunosuppressive function of placenta-derived mesenchymal stromal cells [PDF]
, 2016 Background: Although promising for graft-versus-host disease (GvHD) treatment, MSC therapy still faces important challenges. For instance, increasing MSC migratory capacity as well as potentializing immune response suppression are of interest.
Araujo, Felipe Saldanha de +9 more
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Regulation of LL-37 in Bone and Periodontium Regeneration
Life, 2022 The goal of regenerative therapy is to restore the structure and function of the lost tissues in the fields of medicine and dentistry. However, there are some challenges in regeneration therapy such as the delivery of oxygen and nutrition, and the risk of infection in conditions such as periodontitis, osteomyelitis, etc. Leucine leucine-37 (LL-37) is a
Zahra Chinipardaz +2 more
openaire +3 more sources
Frontiers in Bioscience-Landmark, 2021 Human cathelicidin antimicrobial peptide LL-37 (LL-37) is an antimicrobial peptide derived from its precursor protein hCAP18, which is an only cathelicidin in human.
Keqiang Chen +4 more
doaj +1 more source
Bicarbonate induces high-level resistance to the human antimicrobial peptide LL-37 in Staphylococcus aureus small colony variants [PDF]
, 2017 Objectives: Staphylococcus aureus small colony variants (SCVs) cause persistent infections and are resistant to cationic antibiotics. Antimicrobial peptides (AMPs) have been suggested as promising alternatives for treating antibiotic-resistant bacteria ...
Nair, SP, Tymon, A, Wright, JA, Zhang, P
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Significance of LL‐37 on Immunomodulation and Disease Outcome
BioMed Research International, 2020 LL‐37, also called cathelicidin, is an important part of the human immune system, which can resist various pathogens. A plethora of experiments have demonstrated that it has the multifunctional effects of immune regulation, in addition to antimicrobial activity. Recently, there have been increasing interest in its immune function.
Binbin Yang +11 more
openaire +4 more sources
Activation of TRPV2 and BKCa channels by the LL-37 enantiomers stimulates calcium entry and migration of cancer cells. [PDF]
, 2016 International audienceExpression of the antimicrobial peptide hCAP18/LL-37 is associated to malignancy in various cancer forms, stimulating cell migration and metastasis. We report that LL-37 induces migration of three cancer cell lines by activating the
Aucagne, Vincent +13 more
core +2 more sources
In vivo therapeutic efficacy of frog skin-derived peptides against Pseudomonas aeruginosa-induced pulmonary infection [PDF]
, 2017 Pseudomonas aeruginosa is an opportunistic and frequently drug-resistant pulmonary pathogen especially in cystic fibrosis sufferers. Recently, the frog skin-derived antimicrobial peptide (AMP) Esc(1-21) and its diastereomer Esc(1-21)-1c were found to ...
Chen, Chen +2 more
core +1 more source