Characterizing the role of cell-wall β-1,3-exoglucanase Xog1p in Candida albicans adhesion by the human antimicrobial peptide LL-37. [PDF]
PLoS ONE, 2011 Candida albicans is the major fungal pathogen of humans. Its adhesion to host-cell surfaces is the first critical step during mucosal infection. Antimicrobial peptides play important roles in the first line of mucosal immunity against C.
Pei-Wen Tsai +3 more
doaj +1 more source
Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartment [PDF]
, 2015 This is the peer reviewed version of the following article: Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartment.
Alcala, Sonia +16 more
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Role of antimicrobial peptides in tuberculosis and respiratory tract infections : clinical and mechanistic studies [PDF]
, 2015 Antimicrobial peptides (AMPs) are effector molecules of the innate immune system in multicellular organisms. They are mainly expressed in epithelial cells and immune cells, providing the first line of defense against a wide range of pathogens.
Rekha, Rokeya Sultana
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Cell Death Discovery, 2022 Cathelicidin hCAP18/LL-37 can resist infection from various pathogens and is an essential component of the human immune system. Accumulating evidence has indicated that hCAP18/LL-37 plays a tissue-specific role in human cancer.
Huidan Zhang +7 more
doaj +1 more source
Antimicrobial peptides, disease severity and exacerbations in bronchiectasis [PDF]
, 2019 Rationale: Recently a frequent exacerbator phenotype has been described in bronchiectasis, but the underlying biological mechanisms are unknown. Antimicrobial peptides (AMPs) are important in host defence against microbes but can be proinflammatory in ...
Aliberti, Stefano +14 more
core +2 more sources
Cationic Peptides Facilitate Iron-induced Mutagenesis in Bacteria [PDF]
, 2015 Pseudomonas aeruginosa is the causative agent of chronic respiratory infections and is an important pathogen of cystic fibrosis patients. Adaptive mutations play an essential role for antimicrobial resistance and persistence.
Makarova, Olga +3 more
core +3 more sources
Structural and functional analysis of the pro-domain of human cathelicidin, LL-37 [PDF]
, 2013 Cathelicidins form a family of small host defense peptides distinct from another class of cationic antimicrobial peptides, the defensins. They are expressed as large precursor molecules with a highly conserved pro-domain known as the cathelin-like domain
Beckley, Amy J. +12 more
core +1 more source
Human host-defense peptide LL-37 targets stealth siderophores
Biochemical and Biophysical Research Communications, 2020 A growing number of evidence shows that human-associated microbiota is an important contributor in health and disease. However, much of the complexity of host-microbiota interaction remains to be elucidated both at cellular and molecular levels. Siderophores are chemically diverse, ferric-specific chelators synthesized and secreted by microbes to ...
Ferenc Zsila, Tamás Beke-Somfai
openaire +2 more sources
Efficacy of sodium butyrate adjunct therapy in shigellosis: a randomized, double-blind, placebo-controlled clinical trial [PDF]
, 2012 BACKGROUND: Treatment of shigellosis in rabbits with butyrate reduces clinical severity and counteracts the downregulation of cathelicidin (CAP-18) in the large intestinal epithelia.
Abu Saleh Mohammed Arifuzzaman +9 more
core +1 more source
Transmembrane Pores Formed by Human Antimicrobial Peptide LL-37 [PDF]
Biophysical Journal, 2011 Human LL-37 is a multifunctional cathelicidin peptide that has shown a wide spectrum of antimicrobial activity by permeabilizing microbial membranes similar to other antimicrobial peptides; however, its molecular mechanism has not been clarified. Two independent experiments revealed LL-37 bound to membranes in the α-helical form with the axis lying in ...
Lee, Chang-Chun +3 more
openaire +2 more sources