Results 21 to 30 of about 80,618 (294)

Involvement of Cdk5 activating subunit p35 in synaptic plasticity in excitatory and inhibitory neurons

Molecular Brain, 2022
Cyclin-dependent kinase 5 (Cdk5) /p35 is involved in many developmental processes of the central nervous system. Cdk5/p35 is also implicated in synaptic plasticity, learning and memory.
Miyuki Takahashi, Takeru Nakabayashi, Naoki Mita, Xiaohua Jin, Yuta Aikawa, Kodai Sasamoto, Goichi Miyoshi, Mariko Miyata, Takafumi Inoue, Toshio Ohshima   +9 more
doaj   +1 more source

Bidirectional Synaptic Plasticity Is Driven by Sex Neurosteroids Targeting Estrogen and Androgen Receptors in Hippocampal CA1 Pyramidal Neurons

Frontiers in Cellular Neuroscience, 2019
Neuroactive estrogenic and androgenic steroids influence synaptic transmission, finely modulating synaptic plasticity in several brain regions including the hippocampus.
Alessandro Tozzi, Valentina Durante, Paolo Manca, Michela Di Mauro, Juan Blasi, Silvarosa Grassi, Paolo Calabresi, Suguru Kawato, Suguru Kawato, Vito Enrico Pettorossi   +9 more
doaj   +1 more source

The roles of STP and LTP in synaptic encoding [PDF]

PeerJ, 2013
Long-term potentiation (LTP), a cellular model of learning and memory, is generally regarded as a unitary phenomenon that alters the strength of synaptic transmission by increasing the postsynaptic response to the release of a quantum of neurotransmitter.
Arturas Volianskis, Graham L. Collingridge, Morten S. Jensen   +2 more
doaj   +2 more sources

Cardiac Arrest Induces Ischemic Long-Term Potentiation of Hippocampal CA1 Neurons That Occludes Physiological Long-Term Potentiation

Neural Plasticity, 2018
Ischemic long-term potentiation (iLTP) is a form of synaptic plasticity that occurs in acute brain slices following oxygen-glucose deprivation. In vitro, iLTP can occlude physiological LTP (pLTP) through saturation of plasticity mechanisms.
James E. Orfila, Nicole McKinnon, Myriam Moreno, Guiying Deng, Nicholas Chalmers, Robert M. Dietz, Paco S. Herson, Nidia Quillinan   +7 more
doaj   +1 more source

The α1 subunit of the GABA(A) receptor modulates fear learning and plasticity in the lateral amygdala

Frontiers in Behavioral Neuroscience, 2009
Synaptic plasticity in the amydgala is essential for emotional learning. Fear conditioning, for example, depends on changes in excitatory transmission that occur following NMDA receptor activation and AMPA receptor modification in this region. The role
Brian J Wiltgen, Brian J Wiltgen, Bill Godsil, Bill Godsil, Zechun Peng, Zechun Peng, Faysal Saab, Faysal Saab, Harry June, Michael L Van Linn, James M Cook, Carolyn Houser, Carolyn Houser, Thomas O’dell, Thomas O’dell, Gregg E Homanics, Michael Fanselow, Michael Fanselow   +17 more
doaj   +1 more source

Long Term Potentiation as a Mechanism for Learning and Memory [PDF]

Cell Journal, 2009
Since the 1970s when long term potentiation (LTP) was introduced to the scientific world;several studies have been devoted to determining whether this phenomenon is naturally abasic mechanism of learning and memory in mammalian brains. However, plenty of
Gholamali Hamidi, Sayyed Alireza Talaei Zavareh, Mahmoud Salami   +2 more
doaj  

Temporal sensitivity of protein kinase a activation in late-phase long term potentiation. [PDF]

PLoS Computational Biology, 2010
Protein kinases play critical roles in learning and memory and in long term potentiation (LTP), a form of synaptic plasticity. The induction of late-phase LTP (L-LTP) in the CA1 region of the hippocampus requires several kinases, including CaMKII and PKA,
MyungSook Kim, Ted Huang, Ted Abel, Kim T Blackwell   +3 more
doaj   +1 more source

Effects of intra-dentate gyrus microinjection of myokine irisin on long-term potentiation in male rats [PDF]

Arquivos de Neuro-Psiquiatria, 2020
Induction of long-term potentiation (LTP) increases the storage capacity of synapses in the hippocampal dentate gyrus (DG). Irisin is a myokine generated from FNDC5 (a gene precursor) during exercise.
Saeed Mohammadi, Shahrbanoo Oryan, Alireza Komaki, Akram Eidi, Mohammad Zarei   +4 more
doaj   +1 more source

Erythropoietin enhances hippocampal long-term potentiation and memory

BMC Biology, 2008
Background Erythropoietin (EPO) improves cognition of human subjects in the clinical setting by as yet unknown mechanisms. We developed a mouse model of robust cognitive improvement by EPO to obtain the first clues of how EPO influences cognition, and ...
El-Kordi Ahmed, Radyushkin Konstantin, Sperling Swetlana, Hannke Kathrin, Hassouna Imam, Müller Michael, Zhang Mingyue, Theis Fabian, Gertler Christoph, Medrihan Lucian, Stradomska Alicja, Sargin Derya, Adamcio Bartosz, Schulze Lizzy, Ronnenberg Anja, Wolf Fred, Brose Nils, Rhee Jeong-Seop, Zhang Weiqi, Ehrenreich Hannelore   +19 more
doaj   +1 more source

Convergent evidence for abnormal striatal synaptic plasticity in dystonia

Neurobiology of Disease, 2010
Dystonia is a functionally disabling movement disorder characterized by abnormal movements and postures. Although substantial recent progress has been made in identifying genetic factors, the pathophysiology of the disease remains a mystery.
David A. Peterson, Terrence J. Sejnowski, Howard Poizner   +2 more
doaj   +1 more source