Results 21 to 30 of about 3,075,584 (328)

A prelude to long-term potentiation [PDF]

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2003
Abstract Searching for premonitory studies of hippocampal long-term potentiation (LTP), there is a paucity of data. While synaptic enhancement during repetitive activation was studied in several reports from many groups between 1955 and 1967, the reported after-effects were short, at the most lasting a few minutes.
openaire   +3 more sources

The roles of STP and LTP in synaptic encoding [PDF]

PeerJ, 2013
Long-term potentiation (LTP), a cellular model of learning and memory, is generally regarded as a unitary phenomenon that alters the strength of synaptic transmission by increasing the postsynaptic response to the release of a quantum of neurotransmitter.
Arturas Volianskis, Graham L. Collingridge, Morten S. Jensen   +2 more
doaj   +2 more sources

Cardiac Arrest Induces Ischemic Long-Term Potentiation of Hippocampal CA1 Neurons That Occludes Physiological Long-Term Potentiation

Neural Plasticity, 2018
Ischemic long-term potentiation (iLTP) is a form of synaptic plasticity that occurs in acute brain slices following oxygen-glucose deprivation. In vitro, iLTP can occlude physiological LTP (pLTP) through saturation of plasticity mechanisms.
James E. Orfila, Nicole McKinnon, Myriam Moreno, Guiying Deng, Nicholas Chalmers, Robert M. Dietz, Paco S. Herson, Nidia Quillinan   +7 more
doaj   +1 more source

The α1 subunit of the GABA(A) receptor modulates fear learning and plasticity in the lateral amygdala

Frontiers in Behavioral Neuroscience, 2009
Synaptic plasticity in the amydgala is essential for emotional learning. Fear conditioning, for example, depends on changes in excitatory transmission that occur following NMDA receptor activation and AMPA receptor modification in this region. The role
Brian J Wiltgen, Brian J Wiltgen, Bill Godsil, Bill Godsil, Zechun Peng, Zechun Peng, Faysal Saab, Faysal Saab, Harry June, Michael L Van Linn, James M Cook, Carolyn Houser, Carolyn Houser, Thomas O’dell, Thomas O’dell, Gregg E Homanics, Michael Fanselow, Michael Fanselow   +17 more
doaj   +1 more source

Learning to Bid Long-Term: Multi-Agent Reinforcement Learning with Long-Term and Sparse Reward in Repeated Auction Games [PDF]

arXiv, 2022
We propose a multi-agent distributed reinforcement learning algorithm that balances between potentially conflicting short-term reward and sparse, delayed long-term reward, and learns with partial information in a dynamic environment. We compare different long-term rewards to incentivize the algorithm to maximize individual payoff and overall social ...
arxiv  

Optimized Periodic Coulomb Potential in Two Dimension [PDF]

J. Comput. Phys. 206, 111 (2005), 2004
The 1/r Coulomb potential is calculated for a two dimensional system with periodic boundary conditions. Using polynomial splines in real space and a summation in reciprocal space we obtain numerically optimized potentials which allow us efficient calculations of any periodic (long-ranged) potential up to high precision.
arxiv   +1 more source

Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.

Proceedings of the National Academy of Sciences of the United States of America, 1995
Brain-derived neurotrophic factor (BDNF), a member of the nerve growth factor (NGF) gene family, has been shown to influence the survival and differentiation of specific classes of neurons in vitro and in vivo. The possibility that neurotrophins are also
M. Korte, P. Carroll, Eckhard Wolf, G. Brem, H. Thoenen, T. Bonhoeffer   +5 more
semanticscholar   +1 more source

Long-term potentiation: Peeling the onion [PDF]

Neuropharmacology, 2013
Since the discovery of long-term potentiation (LTP), thousands of papers have been published on this phenomenon. With this massive amount of information, it is often difficult, especially for someone not directly involved in the field, not to be overwhelmed.
Nicoll, Roger A, Roche, Katherine W
openaire   +4 more sources

Temporal sensitivity of protein kinase a activation in late-phase long term potentiation. [PDF]

PLoS Computational Biology, 2010
Protein kinases play critical roles in learning and memory and in long term potentiation (LTP), a form of synaptic plasticity. The induction of late-phase LTP (L-LTP) in the CA1 region of the hippocampus requires several kinases, including CaMKII and PKA,
MyungSook Kim, Ted Huang, Ted Abel, Kim T Blackwell   +3 more
doaj   +1 more source

Optimizing Audio Recommendations for the Long-Term: A Reinforcement Learning Perspective [PDF]

arXiv, 2023
We present a novel podcast recommender system deployed at industrial scale. This system successfully optimizes personal listening journeys that unfold over months for hundreds of millions of listeners. In deviating from the pervasive industry practice of optimizing machine learning algorithms for short-term proxy metrics, the system substantially ...
arxiv