Results 101 to 110 of about 281,396 (208)

Long non-coding RNAs as regulators of the endocrine system [PDF]

, 2018
Long non-coding RNAs (lncRNAs) are a large and diverse group of RNAs that are often lineage-specific and that regulate multiple biological functions. Many are nuclear and are essential parts of ribonucleoprotein complexes that modify chromatin segments ...
Knoll, Marko, Lodish, Harvey F, Sun, Lei
core   +1 more source

Deciphering the role of non-coding RNAs involved in sorafenib resistance

Heliyon
Sorafenib is an important treatment strategy for advanced hepatocellular carcinoma (HCC). Unfortunately, drug resistance has become a major obstacle in sorafenib application.
FanJing Jing, YunYan Shi, Dong Jiang, Xiao Li, JiaLin Sun, XiaoLei Zhang, Qie Guo   +6 more
doaj   +1 more source

Identification of long non-coding RNAs involved in neuronal development and intellectual disability [PDF]

, 2016
Recently, exome sequencing led to the identification of causal mutations in 16–31% of patients with intellectual disability (ID), leaving the underlying cause for many patients unidentified. In this context, the noncoding part of the human genome remains
D'haene, Eva, De Meyer, Tim, Jacobs, Eva, Menten, Björn, Vergult, Sarah, Volders, Pieter-Jan   +5 more
core   +1 more source

Long non-coding RNAs and cancer: a new frontier of translational research? [PDF]

, 2012
Author manuscriptTiling array and novel sequencing technologies have made available the transcription profile of the entire human genome. However, the extent of transcription and the function of genetic elements that occur outside of protein-coding genes,
A Cayre, A Chetcuti, A Colombatti, A Iacoangeli, A Lujambio, A Mishra, A Nahvi, A Pushechnikov, AH Buck, AL Hancock, AM Khalil, AP Bracken, AR Yoon, AS Chan, AT De Souza, AT Willingham, AY Liu, BE Hayward, BL Ebert, BM Owens, C Blin-Wakkach, C Braconi, C Jacquot, C Kanduri, C Liu, CA Thrash-Bingham, CE Foulds, CM Azzalin, D Cazalla, D Reisman, DS Perez, E Sonkoly, E Sunami, EJ Davison, ES Tasheva, F Rossignol, F Wang, FC Noonan, G A Calin, G Bejerano, G Spigoni, G Werstuck, GA Calin, GL Lee, GS Yochum, GT Williams, H Alakus, H Fiegl, H He, H Kawasaki, H Shen, H van Bakel, H van Bakel, HG Laverty, HNC van Bakel, I Martianov, I Pasic, I Revet, I Shamovsky, IJ Matouk, IJ Matouk, IY Yotova, J Krutzfeldt, J Li, J Li, J Okamoto, J Oliva, J Wang, JC Schwartz, JD Potts, JE Wilusz, JM Franco-Zorrilla, JM Silva, JN Hutchinson, JR Day, JS Mattick, JT Lee, K Li, K Numata, K Panzitt, K Szegedi, K Tanaka, KA Rees, KC Pang, KL Rice, KL Yap, KV Morris, KV Morris, L Benetatos, L Li, L Monti, L Nelles, L Poliseno, LA Hindorff, LJ Ng, LL Chen, M Bedford, M Castelnuovo, M Guttman, M Guttman, M Huarte, M Huarte, M I Almeida, M Malleter, M Mancini, M Martick, M Mourtada-Maarabouni, M Ridanpaa, M Taskinen, MA Cortez, MB Clark, MC Tsai, MD Yan, ME Askarian-Amiri, ME Dinger, ME Dinger, MJ Bussemakers, MM Candeias, MM Pomerantz, MN Cabili, MN Rivera, MR Ginger, MS Kumar, N Berteaux, N Delgado Andre, N Leveille, ND Rintala-Maki, NR Madamanchi, O Makitie, P Ji, P Kapranov, P Mestdagh, P Preker, P Scaruffi, PP Amaral, PP Gardner, R Agrelo, R Cordaux, R Kogo, R Smith, R Spizzo, R Yang, RA Drewell, RA Gupta, RB Lanz, RC Iskow, RJ Taft, S Brabletz, S Ganesan, S Hanson, S Tochitani, S Tommasi, S Tuupanen, S Washietl, SA Korneev, SC Gopinath, SE Wojcik, SM Colley, SM Weakley, SS Potter, T Hermann, T Kin, T Kino, T Li, T Mondal, T Nakayama, T Sliwinski, T Yoshimizu, TR Mercer, U Klein, UA Orom, UH Frey, V Srikantan, W Chen, W Cheng, W Yu, WP Tsang, X Wang, X Zhang, X Zhang, XS Wang, Y Cao, Y Chu, Y Jeon, Y Maida, Y Okubo, Y Zhang, YM Chau, YS Kim, Z Yang   +189 more
core   +1 more source

Non-coding RNA-mediated gene regulation in Alzheimer's disease pathogenesis: molecular insights and emerging innovations

Saudi Pharmaceutical Journal
The accumulation of pathological markers, such as tau tangles and amyloid-beta (Aβ) plaques, and progressive cognitive dysfunction are the markers of Alzheimer's disease (AD).
Sami I. Alzarea
doaj   +1 more source

Whole transcriptome sequencing of the aging rat brain reveals dynamic RNA changes in the dark matter of the genome [PDF]

, 2012
Brain aging frequently underlies cognitive decline and is a major risk factor for neurodegenerative conditions. The exact molecular mechanisms underlying brain aging, however, remain unknown. Whole transcriptome sequencing provides unparalleled depth and
Brian Merry, João Pedro de Magalhães, Shona H. Wood, Thomas Craig, Yang Li   +4 more
core   +1 more source

Prediction of plant lncRNA by ensemble machine learning classifiers

BMC Genomics, 2018
Background In plants, long non-protein coding RNAs are believed to have essential roles in development and stress responses. However, relative to advances on discerning biological roles for long non-protein coding RNAs in animal systems, this RNA class ...
Caitlin M. A. Simopoulos, Elizabeth A. Weretilnyk, G. Brian Golding   +2 more
doaj   +1 more source

Emerging Roles for Long Non-Coding RNAs in Cancer and Neurological Disorders [PDF]

, 2012
The recent discovery of thousands of large non-coding (lnc)RNAs in the human genome prompted investigation of the potential roles of these molecules in human biology and medicine.
Courtney N. Niland, Callie R. Merry, Ahmad M. Khalil   +2 more
core   +1 more source

Long non-coding RNA expression profile in cytogenetically normal acute myeloid leukemia identifies a distinct signature and a new biomarker in NPM1-mutated patients

Haematologica, 2017
Long non-coding RNAs are defined as transcripts larger than 200 nucleotides but without protein-coding potential. There is growing evidence of the important role of long non-coding RNAs in cancer initiation, development and progression. In this study, we
Etienne De Clara, Morgane Gourvest, Hanjing Ma, François Vergez, Marie Tosolini, Sébastien Dejean, Cécile Demur, Eric Delabesse, Christian Recher, Christian Touriol, Maria Paola Martelli, Brunangelo Falini, Pierre Brousset, Marina Bousquet   +13 more
doaj   +1 more source

Non-coding RNAs as novel biomarkers and therapeutic targets in breast cancer

Oncology Reviews
Breast cancer (BC) remains a leading cause of cancer-related morbidity and mortality worldwide. Its marked heterogeneity - encompassing molecular subtypes, histological characteristics, and variable therapeutic responses - continues to pose persistent ...
Veronica Barbi, Veronica Barbi, Sara De Martino, Aurora Aiello, Michela Gottardi Zamperla, Sara Negri, Luca Cis, Valeria Pecci, Simona Nanni, Simona Nanni, Antonella Farsetti, Fabio Martelli, Carlo Gaetano, Sandra Atlante, Sandra Atlante   +14 more
doaj   +1 more source