Results 81 to 90 of about 281,396 (208)
, 2015 Rapid development in genome-wide transcriptional analyses has led to the discovery of a large number of non-coding transcripts, also called long non-coding RNA (lncRNA). LncRNAs harbor biological activities including regulation of protein-coding gene expression at epigenetic, transcriptional and post-transcriptional levels.
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Long non-coding RNAs in neurodevelopmental disorders
Frontiers in Molecular Neuroscience, 2013 Recent studies have emphasized an important role for long non-coding RNAs (lncRNA) in epigenetic regulation, development, and disease. Despite growing interest in lncRNAs, the mechanisms by which lncRNAs control cellular processes are still elusive ...
Ilse Ida Gerarda Maria Van De Vondervoort +15 more
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Into the Wild: GWAS Exploration of Non-coding RNAs [PDF]
, 2018 Genome-wide association studies (GWAS) have proven a fundamental tool to identify common variants associated to complex traits, thus contributing to unveil the genetic components of human disease.
Giral, Hector +2 more
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Long Non-Coding RNAs in Multiple Myeloma
Non-Coding RNA, 2019 Multiple myeloma (MM) is the second most common hematooncological disease of malignant plasma cells in the bone marrow. While new treatment brought unprecedented increase of survival of patients, MM pathogenesis is yet to be clarified.
Romana Butova +4 more
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Long non-coding RNA SENCR is a positive regulator of ETV2 [PDF]
, 2017 Department of Biological SciencesAlthough long non-coding RNAs (lncRNAs) have emerged as novel regulator of cell fate and gene expression, the regulation of vascular specific transcription factor by lncRNA in generation of induced endothelial cells ...
Jeong, Yujin
core
Communications BiologyDespite regulatory elements such as long non - coding RNAs representing most of the transcriptome, the functional understanding of long non - coding RNAs in relation to major health conditions including bovine mastitis is limited. This study examined the
Victoria Asselstine +5 more
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The function and mechanisms of action of non-coding RNAs in prostatic diseases
Cell InvestigationNon-coding RNAs (ncRNAs) are RNA molecules that lack protein-coding capacity. In recent years, research interest has surged in the roles of long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and microRNAs (miRNAs) in prostate diseases, including ...
Zhongpeng Zheng +5 more
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Long Non-coding RNAs in Endothelial Biology
Frontiers in Physiology, 2018 In recent years, the role of RNA has expanded to the extent that protein-coding RNAs are now the minority with a variety of non-coding RNAs (ncRNAs) now comprising the majority of RNAs in higher organisms.
Tyler Weirick +2 more
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Whole transcriptome profiling reveals the RNA content of motor axons [PDF]
, 2015 Most RNAs within polarized cells such as neurons are sorted subcellularly in a coordinated manner. Despite advances in the development of methods for profiling polyadenylated RNAs from small amounts of input RNA, techniques for profiling coding and non ...
Appenzeller, Silke +5 more
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Regulation of the ESC transcriptome by nuclear long non-coding RNAs [PDF]
, 2015 Long noncoding (lnc)RNAs have recently emerged as key regulators of gene expression. Here, we performed high-depth poly(A)+ RNA sequencing across multiple clonal populations of mouse embryonic stem cells (ESCs) and neural progenitor cells (NPCs) to ...
Bergmann, J. H. +5 more
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