Results 71 to 80 of about 185,323 (261)

Long non-coding RNAs in neurodevelopmental disorders

Frontiers in Molecular Neuroscience, 2013
Recent studies have emphasized an important role for long non-coding RNAs (lncRNA) in epigenetic regulation, development, and disease. Despite growing interest in lncRNAs, the mechanisms by which lncRNAs control cellular processes are still elusive ...
Ilse Ida Gerarda Maria Van De Vondervoort, Ilse Ida Gerarda Maria Van De Vondervoort, Peter M Gordebeke, Peter M Gordebeke, Nima eKhoshab, Nima eKhoshab, Paul H E Tiesinga, Paul H E Tiesinga, Jan K Buitelaar, Jan K Buitelaar, Tamas eKozicz, Tamas eKozicz, Jeffrey C Glennon, Jeffrey C Glennon, Armaz eAschrafi, Armaz eAschrafi   +15 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Long non-coding RNAs and hepatocellular carcinoma

Molecular and Clinical Oncology, 2014
Recent advances in next-generation sequencing technology in transcriptome analysis have helped identify numerous non-coding RNAs. The long non-coding RNA (lncRNA) is commonly defined as an RNA molecule with a length of 200 bp-100 kbp that lacks protein-coding potential.
Fu-Jun, Yu, Jian-Jian, Zheng, Pei-Hong, Dong, Xiao-Ming, Fan   +3 more
openaire   +3 more sources

Novel lncRNA regulatory elements in milk somatic cells of Holstein dairy cows associated with mastitis

Communications Biology
Despite regulatory elements such as long non - coding RNAs representing most of the transcriptome, the functional understanding of long non - coding RNAs in relation to major health conditions including bovine mastitis is limited. This study examined the
Victoria Asselstine, Juan F. Medrano, Malane M. M. Muniz, Bonnie A. Mallard, Niel A. Karrow, Angela Cánovas   +5 more
doaj   +1 more source

Long Non-Coding RNAs in Multiple Myeloma

Non-Coding RNA, 2019
Multiple myeloma (MM) is the second most common hematooncological disease of malignant plasma cells in the bone marrow. While new treatment brought unprecedented increase of survival of patients, MM pathogenesis is yet to be clarified.
Romana Butova, Petra Vychytilova-Faltejskova, Adela Souckova, Sabina Sevcikova, Roman Hajek   +4 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Exploring the role of non-coding RNAs in retinoblastoma: mechanism of contribution, biomarker potential, therapeutic opportunities, and encountered challenges

Egyptian Journal of Medical Human Genetics
Retinoblastoma (RB) is a primary cancer of the eye that predominantly affects children, although rare adult cases have been reported. This malignancy arises from immature retinal cells and is a major cause of vision loss in the pediatric population.
Alireza Azani, Zahra Mehrdad, Vahid Ghassemifar, Pegah Kavousinia, Parsa Lorestani, Malihe Sharafi, Alireza Mojarrad, Haniyeh Ghasrsaz, Sepide Javankiani, Mohammad Saeed Soleimani Meigoli, Safa Tahmasebi, Faeze Ahmadi Beni, Qumars Behfar   +12 more
doaj   +1 more source

Long Non-coding RNAs in Endothelial Biology

Frontiers in Physiology, 2018
In recent years, the role of RNA has expanded to the extent that protein-coding RNAs are now the minority with a variety of non-coding RNAs (ncRNAs) now comprising the majority of RNAs in higher organisms.
Tyler Weirick, Giuseppe Militello, Shizuka Uchida   +2 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

The function and mechanisms of action of non-coding RNAs in prostatic diseases

Cell Investigation
Non-coding RNAs (ncRNAs) are RNA molecules that lack protein-coding capacity. In recent years, research interest has surged in the roles of long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and microRNAs (miRNAs) in prostate diseases, including ...
Zhongpeng Zheng, George Pupwe, Kyle Takehiro, Guopeng Yu, Ming Zhan, Bin Xu   +5 more
doaj   +1 more source