Results 211 to 220 of about 185,323 (261)

TSTScope Unifies Single‐Cell Multi‐Omics to Identify Functional T Cell States Predictive of Immunotherapy Response

open access: yesAdvanced Science, EarlyView.
TSTScope is an interpretable AI framework that integrates single‐cell transcriptomes with TCR information through curated gene‐program constraints. By linking receptor context to functional T cell states, it reveals response‐associated tumor‐specific T cell programs in lung cancer immunotherapy cohorts and defines an MPR score associated with ...
Shiwei Cao   +8 more
wiley   +1 more source

Long non-coding RNAs in response to Ebola virus vaccine-induced immunity. [PDF]

open access: yesFront Immunol
Mamede I   +20 more
europepmc   +1 more source

Targeting Hippocampal PTEN Suppresses Ferroptosis and Rescues Cognitive Decline in Alzheimer's Disease via Dual AKT/GSK3β/Nrf2 and AKT/STAT3 Axes

open access: yesAdvanced Science, EarlyView.
PTEN knockdown activates AKT phosphorylation, promoting Nrf2 nuclear translocation and STAT3 activation, which upregulates GPX4 and antioxidant enzymes HO‐1, SOD1, SOD2, and NQO1. These coordinated changes reduce lipid peroxidation and ROS, inhibit ferroptosis, and ultimately ameliorate cognitive impairment in APP/PS1 transgenic mice, highlighting a ...
Da‐Wei Wang   +5 more
wiley   +1 more source

Correction: Long non-coding RNAs in response to Ebola virus vaccine-induced immunity. [PDF]

open access: yesFront Immunol
Mamede I   +20 more
europepmc   +1 more source

Macrophage-derived long non-coding RNAs in cancer: pioneering targets for immune modulation and personalized therapy. [PDF]

open access: yesFront Immunol
Ramalingam PS   +11 more
europepmc   +1 more source

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