Results 221 to 230 of about 185,323 (261)

Long Non-coding RNAs in Rheumatology

2022
The last decade has seen an enormous increase in long non-coding RNA (lncRNA) research within rheumatology. LncRNAs are arbitrarily classed as non-protein encoding RNA transcripts that exceed 200 nucleotides in length. These transcripts have tissue and cell specific patterns of expression and are implicated in a variety of biological processes ...
Susanne N, Wijesinghe, Mark A, Lindsay, Simon W, Jones   +2 more
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Long non-coding RNAs and splicing

Essays in Biochemistry, 2021
Abstract In this review I focus on the role of splicing in long non-coding RNA (lncRNA) life. First, I summarize differences between the splicing efficiency of protein-coding genes and lncRNAs and discuss why non-coding RNAs are spliced less efficiently.
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Infectious long non-coding RNAs

Biochimie, 2015
Long non protein coding RNAs (lncRNAs) constitute a large category of the RNA world, able to regulate different biological processes. In this review we are focusing on infectious lncRNAs, their classification, pathogenesis and impact on the infected organisms.
Konstantina, Katsarou, A L N, Rao, Mina, Tsagris, Kriton, Kalantidis   +3 more
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Long non-coding RNAs and pyroptosis

Clinica Chimica Acta, 2020
Long noncoding RNAs (lncRNAs) are defined as transcripts longer than 200 nucleotides that have no or only a low coding potential. They are involved in the progression of multiple diseases by the regulation of mechanisms related to epigenetic modifications and transcriptional and posttranscriptional processing.
Dong He, Jun Zheng, Jia Hu, Juan Chen, Xing Wei   +4 more
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Long non-coding RNAs in retinoblastoma

Pathology - Research and Practice, 2019
Retinoblastoma represents 3% of all childhood cancers and is the most common intraocular malignant tumor with a highly aggressive and metastatic phenotype. While recent genetic and epigenetic studies have reported new insights into the mechanism of retinoblastoma development, the involvement of regulatory non-coding RNAs remains unclear.
Ming, Yang, Wenbin, Wei
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Long non-coding RNAs in metastasis

Cancer and Metastasis Reviews, 2017
Long non-coding RNA (lncRNA) genes have recently been discovered as key regulators of developmental, physiological, and pathological processes in humans. Recent studies indicate that lncRNAs regulate every step of gene expression, and their aberrant expression can be found in the majority of cancer types. Particularly, lncRNAs were found to function in
Qihong, Huang, Jinchun, Yan, Reuven, Agami   +2 more
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Long non-coding RNAs in schizophrenia

Clinica Chimica Acta
Long noncoding RNAs (lncRNAs) have emerged as critical regulators of the pathogenesis of schizophrenia, a complex neuropsychiatric disorder influenced by genetic and environmental factors. These transcripts modulate gene expression through diverse mechanisms, including chromatin remodeling, transcriptional regulation, and posttranscriptional ...
Seyyed Navid, Mousavinejad, Seyed Ali, Hosseini, Mozhdeh, Mohammadpour, Felora, Ferdosi, Ehsan, Dadgostar, Siavash, Abdolghaderi, Seyyed Hossein, Khatami   +6 more
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Long non-coding RNA HCP5 in cancer

Clinica Chimica Acta, 2021
Cancer remains a major threat to human health worldwide. Long non-coding RNA (lncRNA) comprises a group of single-stranded RNA with lengths longer than 200 bp. LncRNAs are aberrantly expressed and play a variety of roles involving multiple cellular processes in cancer.
Yuanzhang Zou, Binghai Chen
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“Going Long”: Long Non-Coding RNAs as Biomarkers

Circulation Research, 2014
Protein-coding sequences constitute 200 nucleotides). Since their discovery in 2001, miRNAs have been studied extensively and fundamental insights have been obtained about their synthesis, their repression of target genes, and their involvement in disease processes. Indeed, miRNA therapeutics are already tested in clinical trials. Article, see p 668
Philipp, Skroblin, Manuel, Mayr
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Long non-coding RNAs: insights into functions

Nature Reviews Genetics, 2009
In mammals and other eukaryotes most of the genome is transcribed in a developmentally regulated manner to produce large numbers of long non-coding RNAs (ncRNAs). Here we review the rapidly advancing field of long ncRNAs, describing their conservation, their organization in the genome and their roles in gene regulation.
Mercer, T. R., Dinger, M. E., Mattick, J. S.   +2 more
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