The how and why of lncRNA function: An innate immune perspective. [PDF]
, 2020 Next-generation sequencing has provided a more complete picture of the composition of the human transcriptome indicating that much of the "blueprint" is a vastness of poorly understood non-protein-coding transcripts.
Carpenter, Susan +2 more
core
Genomics and proteomics: a signal processor's tour [PDF]
, 2004 The theory and methods of signal processing are becoming increasingly important in molecular biology. Digital filtering techniques, transform domain methods, and Markov models have played important roles in gene identification, biological sequence ...
Vaidyanathan, P. P.
core +2 more sources
The long non-coding RNA Kcnq1ot1 controls maternal p57 expression in muscle cells by promoting H3K27me3 accumulation to an intragenic MyoD-binding region [PDF]
, 2019 BACKGROUND: The cell-cycle inhibitor p57kip2 plays a critical role in mammalian development by coordinating cell proliferation and differentiation in many cell types.
Andresini, Oriella +5 more
core +4 more sources
Long noncoding RNA Cfast regulates cardiac fibrosis
Molecular Therapy: Nucleic Acids, 2021 Cardiac fibrosis occurs in most cardiac diseases, which reduces cardiac muscle compliance, impairs both systolic and diastolic heart function and, ultimately, leads to heart failure.
Feng Zhang +17 more
doaj +1 more source
The Long Noncoding RNA HEAL Regulates HIV-1 Replication through Epigenetic Regulation of the HIV-1 Promoter. [PDF]
, 2019 A major challenge in finding a cure for HIV-1/AIDS is the difficulty in identifying and eradicating persistent reservoirs of replication-competent provirus.
Chang, Kungyen +11 more
core +1 more source
Long noncoding RNAs in lipid metabolism [PDF]
Current Opinion in Lipidology, 2018 Purpose of review Noncoding RNAs have emerged as important regulators of cellular and systemic lipid metabolism. In particular, the enigmatic class of long noncoding RNAs have been shown to play multifaceted roles in controlling transcriptional and posttranscriptional gene regulation. In this review, we discuss recent advances,
Coen, van Solingen +2 more
openaire +2 more sources
Long noncoding RNAs in innate immunity [PDF]
Cellular & Molecular Immunology, 2015 Long noncoding RNAs (lncRNAs) have been shown to play important roles in immune cell development and immune responses through different mechanisms, such as dosage compensation, imprinting, enhancer function, and transcriptional regulation. Although the functions of most lncRNAs are unclear, some lncRNAs have been found to control transcriptional or ...
Zhang, Yuan, Cao, Xuetao
openaire +2 more sources
Single cell analysis reveals the involvement of the long non-coding RNA Pvt1 in the modulation of muscle atrophy and mitochondrial network [PDF]
, 2019 Long non-coding RNAs (lncRNAs) are emerging as important players in the regulation of several aspects of cellular biology. For a better comprehension of their function, it is fundamental to determine their tissue or cell specificity and to identify their
Alessio, Enrico +13 more
core +1 more source
Divergent lncRNAs take the lead on pluripotent cell differentiation [PDF]
, 2016 [No abstract ...
Ballarino, Monica, Rosa, Alessandro
core +1 more source
Noncoding RNAs Associated with Therapeutic Resistance in Pancreatic Cancer
Biomedicines, 2021 Therapeutic resistance is an inevitable impediment towards effective cancer therapies. Evidence accumulated has shown that the signaling pathways and related factors are fundamentally responsible for therapeutic resistance via regulating diverse cellular
Seung Wan Son +3 more
doaj +1 more source