Results 11 to 20 of about 9,152,726 (291)

Long-read sequencing for brain tumors [PDF]

Frontiers in Oncology
Brain tumors and genomics have a long-standing history given that glioblastoma was the first cancer studied by the cancer genome atlas. The numerous and continuous advances through the decades in sequencing technologies have aided in the advanced ...
William J. Shelton, Sara Zandpazandi, J Stephen Nix, Murat Gokden, Michael Bauer, Katie Rose Ryan, Christopher P. Wardell, Olena Morozova Vaske, Analiz Rodriguez   +8 more
doaj   +6 more sources

The application of long-read sequencing in clinical settings [PDF]

Human Genomics, 2023
Long-read DNA sequencing technologies have been rapidly evolving in recent years, and their ability to assess large and complex regions of the genome makes them ideal for clinical applications in molecular diagnosis and therapy selection, thereby ...
Josephine B. Oehler, Helen Wright, Zornitza Stark, Andrew J. Mallett, Ulf Schmitz   +4 more
doaj   +7 more sources

Deciphering transcriptome complexity via long‐read sequencing [PDF]

iMeta
Transcriptomics is moving beyond gene‐level quantification toward isoform‐resolved interrogation of alternative splicing, transcript structural variation, and repeat‐derived transcription.
Chuwen Xu, Jia Li, Chenxi Yin, Keying Li, Tian Wang, Shiwen Gao, Yue Yu, Cheng Chang, Ye Wang, Guoqing Tong, Liang Gong, Wen Hu, Guoliang Chai, Yilai Han, Qian Qin, Suoqin Jin, Xiufen Zou, Bo Li, Tianyuan Zhang, Ana Conesa, Yunhao Wang, Dingjie Wang   +21 more
doaj   +2 more sources

Long-Read Sequencing Emerging in Medical Genetics [PDF]

Frontiers in Genetics, 2019
The wide implementation of next-generation sequencing (NGS) technologies has revolutionized the field of medical genetics. However, the short read lengths of currently used sequencing approaches pose a limitation for the identification of structural ...
Tuomo Mantere, Tuomo Mantere, Simone Kersten, Simone Kersten, Simone Kersten, Alexander Hoischen, Alexander Hoischen, Alexander Hoischen   +7 more
doaj   +5 more sources

Migrating to Long-Read Sequencing for Clinical Routine TKI Resistance Mutation Screening

Cancer Informatics, 2022
Objective: The aim of this project was to implement long-read sequencing for BCR-ABL1 TKI resistance mutation screening in a clinical setting for patients undergoing treatment for chronic myeloid leukemia.
Wesley Schaal, Adam Ameur, Ulla Olsson-Strömberg, Monica Hermanson, Lucia Cavelier, Ola Spjuth   +5 more
doaj   +2 more sources

Applications of long-read sequencing to Mendelian genetics

Genome Medicine, 2023
Advances in clinical genetic testing, including the introduction of exome sequencing, have uncovered the molecular etiology for many rare and previously unsolved genetic disorders, yet more than half of individuals with a suspected genetic disorder ...
Francesco Kumara Mastrorosa, Danny E. Miller, Evan E. Eichler   +2 more
doaj   +3 more sources

Long-Read Nanopore-Based Sequencing of Anelloviruses

Viruses
Routinely used metagenomic next-generation sequencing (mNGS) techniques often fail to detect low-level viremia (
Raghavendran Anantharam, Dylan Duchen, Andrea L. Cox, Winston Timp, David L. Thomas, Steven J. Clipman, Abraham J. Kandathil   +6 more
doaj   +3 more sources

Genome sequencing using long-read sequencing

Revista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturales, 2023
Juan Guillermo McEwen, Oscar Mauricio Gómez   +1 more
doaj   +2 more sources

Why Are Long-Read Sequencing Methods Revolutionizing Microbiome Analysis?

Microorganisms
Most of the knowledge available on the composition and functionality of microbial communities in different ecosystems comes from short-read sequencing methods.
Adriana González, Asier Fullaondo, Adrian Odriozola   +2 more
doaj   +2 more sources

Identification of the Novel HLA‐A*02:04:03 Allele by Long‐Read Sequencing Following a Short‐Read Phasing Failure [PDF]

HLA
The novel allele HLA‐A*02:04:03 was detected with long‐read sequencing but failed to be detected by short‐read sequencing.
Pernille Koefoed‐Nielsen, Maja Nørgaard   +1 more
core   +2 more sources