Results 81 to 90 of about 327,413 (252)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Mapping-based genome size estimation
BMC GenomicsWhile the size of chromosomes can be measured under a microscope, obtaining the exact size of a genome remains a challenge. Biochemical methods and k-mer distribution-based approaches allow only estimations. An alternative approach to estimate the genome
Shakunthala Natarajan +2 more
doaj +1 more source
Transcriptome assembly from long-read RNA-seq alignments with StringTie2
Genome Biology, 2019 RNA sequencing using the latest single-molecule sequencing instruments produces reads that are thousands of nucleotides long. The ability to assemble these long reads can greatly improve the sensitivity of long-read analyses.
Sam Kovaka +5 more
doaj +1 more source
hAssembler: A hybrid de novo genome assembly approach for large genomes
The Indian Journal of Agricultural Sciences, 2020 Genome assembly is a process where large contigs and scaffolds are constructed from raw reads generated by sequencing machines. Based on the size of the generated reads they can be primarily categorized into short reads and long reads.
AMIT KAIRI +2 more
doaj +1 more source
, 2021 Finland is rarely mentioned as an example by leftists and Greens who want to build a better future. Yet this little-noticed country is one of the most equal, peaceful and happiest on the planet. Danny Dorling and Annika Koljonen explain how Finland came to demonstrate the benefits of investing in people – and suggest what its model might have to offer ...
Dorling, D, Koljonen, A
openaire +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
PLoS ONE, 2014 De novo microbial genome sequencing reached a turning point with third-generation sequencing (TGS) platforms, and several microbial genomes have been improved by TGS long reads. Bacillus subtilis natto is closely related to the laboratory standard strain
Mayumi Kamada +5 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Frontiers in Plant ScienceDiplocarpon coronariae is a fungal pathogen that is prevalent in low-input apple production. Over the past 15 years, it has become increasingly distributed in Europe. However, comprehensive insights into its biology and pathogenicity remain limited.
Sophie Richter +13 more
doaj +1 more source