Results 131 to 140 of about 19,126 (200)

Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States

Advanced Science, EarlyView.
Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton, Carrillo Paola Gonzalez, Luay Almassalha, Wing Shun Li, Ruyi Gong, Nicolas Acosta, I Chae Ye, Jane Frederick, Christopher Hogg, Saira John, J. A. Gareth Williams, Rikkert J. Nap, Igal Szleifer, Vadim Backman   +13 more
wiley   +1 more source

Cohesin cofactor dosage sets the rate of loop extrusion, rendering genome folding tunable yet vulnerable to genetic disruption. [PDF]

Mol Cell
Shah R, Tortora MMC, Louafi N, Rahmaninejad H, Hansen KL, Anderson EC, Bonitto K, Wen D, Giorgetti L, Fudenberg G, Nora EP.   +10 more
europepmc   +1 more source

DNA double-strand break end synapsis by DNA loop extrusion. [PDF]

Nat Commun, 2023
Yang JH, Brandão HB, Hansen AS.
europepmc   +1 more source

Review of Gastrointestinal Capsule Robots: Materials, Actuation, Diagnostics, and Therapeutics

Advanced Science, EarlyView.
This review examines gastrointestinal capsule robots through a systems engineering lens, covering shell materials, actuation and localization strategies, diagnostic modalities, therapeutic interventions, and commercialization status. By mapping the complete technological chain from fabrication to clinical deployment, this work identifies critical gaps ...
Zengsheng Li, Zhongguo Ren, Yiliang Lin, Xianfeng Xia, Tianlong Li, Kai Fung Chan, Philip Wai Yan Chiu, Wei Peng Yong, Mengmeng Sun   +8 more
wiley   +1 more source

Uniform dynamics of cohesin-mediated loop extrusion in living human cells. [PDF]

Nat Genet
Sabaté T, Lelandais B, Robert MC, Szalay M, Tinevez JY, Bertrand E, Zimmer C.   +6 more
europepmc   +1 more source

Fob1-dependent condensin recruitment and loop extrusion on yeast chromosome III. [PDF]

PLoS Genet, 2023
Dinda M, Fine RD, Saha S, Wang Z, Zang C, Li M, Smith JS.   +6 more
europepmc   +1 more source

Voltage‐Reconfigurable Magneto‐Ionic Nanolayers in Dot Arrays for Probabilistic, Materials‐Engineered Security Primitives

Advanced Science, EarlyView.
A magneto‐ionic security‐by‐materials‐design strategy exploits voltage‐driven N3– migration in selectively contacted FeCoN dots, creating reconfigurable sub‐15 nm ferromagnetic sublayers with deterministic and/or probabilistic (single‐domain↔vortex) states, voltage‐tunable probabilities and fully stochastic orientation/chirality.
Irena Spasojevic, Federica Celegato, Alessandro Magni, Paola Tiberto, Jordi Sort   +4 more
wiley   +1 more source

Acute NIPBL depletion reveals in vivo dynamics of loop extrusion and its role in transcription activation. [PDF]

Nat Genet
Popay TM, Pant A, Munting F, Tastemel M, Black ME, Haghani N, Dixon JR.   +6 more
europepmc   +1 more source

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

Three-dimensional loop extrusion. [PDF]

Biophys J, 2021
Bonato A, Michieletto D.
europepmc   +1 more source