Results 11 to 20 of about 56,277 (295)

Loqs and R2D2 act sequentially in the siRNA pathway in Drosophila [PDF]

open access: yesNature Structural & Molecular Biology, 2009
In Drosophila melanogaster, the small interfering RNA (siRNA) pathway is triggered by exogenous double-stranded RNA (dsRNA) or upon viral infection. This pathway requires Dicer-2 (Dcr-2) in association with a dsRNA-binding protein (dsRBP) called R2D2.
João Trindade, Marques   +5 more
openaire   +2 more sources

Clinical relevance of an objective flow cytometry approach based on limit of detection and limit of quantification for measurable residual disease assessment in acute myeloid leukemia. A post-hoc analysis of the GIMEMA AML1310 trial

open access: yesHaematologica, 2022
Using a multiparametric flow cytometry assay, we assessed the predictive power of a threshold calculated applying the criteria of limit of detection (LOD) and limit of quantitation (LOQ) in adult patients with acute myeloid leukemia. This was a post-hoc
Francesco Buccisano   +15 more
doaj   +1 more source

Investigating a Simple and Sensitive High-performance Liquid Chromatography Method for Simultaneous Determination of Apigenin, Catalpol, and Gallic Acid Contents in Plantago Lanceolata L. and Plantago Major L. [PDF]

open access: yesPharmaceutical and Biomedical Research, 2023
Background and Objectives: Plantago is a diverse genus of the Plantaginaceae family. Plantago lanceolata L. (P. lanceolata) and Plantago major L. (P. major) are used commercially worldwide as a traditional treatment for many diseases. A sensitive, simple,
Samaneh Rahamouz-Haghighi   +2 more
doaj  

Impact of Seed Treatment with Imidacloprid, Clothianidin and Thiamethoxam on Soil, Plants, Bees and Hive Products

open access: yesAgriculture, 2023
This paper presents studies performed for the monitoring of imidacloprid, clothianidin and thiamethoxam residues applied as seed treatment in rapeseed (Brassica napus ssp. oleifera), maize (Zea mays) and sunflower crops (Helianthus annuus).
Roxana Zaharia   +7 more
doaj   +1 more source

Loqs-PD and R2D2 define independent pathways for RISC generation in Drosophila [PDF]

open access: yesNucleic Acids Research, 2011
In Drosophila, siRNAs are classified as endo- or exo-siRNAs based on their origin. Both are processed from double-stranded RNA precursors by Dcr-2 and then loaded into the Argonaute protein Ago2. While exo-siRNAs serve to defend the cell against viruses, endo-siRNAs restrict the spread of selfish DNA in somatic cells, analogous to piRNAs in the germ ...
Hartig, Julia V., Förstemann, Klaus
openaire   +2 more sources

LOQ-Limit of quantification for SL2 assay.

open access: yes, 2022
LOQ was determined from dilution series, 8 replicates were amplified at concentration of 550000, 110000, 22000, 4400, 880, 176, 35.2, 7.04, 1.408, 0.2816, 0.05632 1μl-1.
Adriana Krolicka (13840124)   +5 more
core   +1 more source

Neonatal Feeding Trajectories in Mothers With Bipolar Disorder Taking Lithium: Pharmacokinetic Data

open access: yesFrontiers in Pharmacology, 2021
Purpose: Women who take lithium during pregnancy and continue after delivery may choose to breastfeed, formula feed, or mix these options. The aim of the study was to evaluate the neonatal lithium serum concentrations based on these three feeding ...
Maria Luisa Imaz   +8 more
doaj   +1 more source

Structural mechanism of R2D2 and Loqs-PD synergistic modulation on DmDcr-2 oligomers

open access: yesNature Communications, 2023
AbstractSmall interference RNAs are the key components of RNA interference, a conserved RNA silencing or viral defense mechanism in many eukaryotes. In Drosophila melanogaster, Dicer-2 (DmDcr-2)-mediated RNAi pathway plays important roles in defending against viral infections and protecting genome integrity.
Ting Deng   +6 more
openaire   +3 more sources

Simultaneous Screening and Determination of Eleven Mycotoxins in Tomato by Ultra-high Performance Liquid Chromatography-Quadrupole/Orbitrap High-Resolution Mass Spectrometry [PDF]

open access: yesShipin Kexue, 2023
A method was developed for the simultaneous screening and determination of eleven mycotoxins in tomato by ultra-high performance liquid chromatography-quadrepole/orbitrap high-resolution mass spectrometry (UPLC-Q/Orbitrap HRMS).
WANG Changzhao, LI Zihao, ZHANG Yali, LIN Fang, LI Jianhua, ZOU Yang, YANG Yue
doaj   +1 more source

Percentage increase compared to LOD and LOQ.

open access: yes, 2023
Theoretically estimated minimal copy numbers required to detect a certain percentage increase of dd-cfDNA fraction (50%, 100% and 150%), compared to LOD and LOQ (represented by dashed lines).
Leif Kofoed Nielsen (14675947)   +4 more
core   +1 more source

Home - About - Disclaimer - Privacy