Results 71 to 80 of about 113,253 (324)

LPA Variants Are Associated With Residual Cardiovascular Risk in Patients Receiving Statins

Circulation, 2018
Background: Coronary heart disease (CHD) is a leading cause of death globally. Although therapy with statins decreases circulating levels of low-density lipoprotein cholesterol and the incidence of CHD, additional events occur despite statin therapy in ...
Wei-Qi Wei, Xiaohui Li, Q. Feng, M. Kubo, I. Kullo, P. Peissig, E. Karlson, G. Jarvik, M. Lee, N. Shang, Eric A. Larson, T. Edwards, C. Shaffer, J. Mosley, S. Maeda, M. Horikoshi, M. Ritchie, Marc S. Williams, E. Larson, D. Crosslin, S. Bland, J. Pacheco, L. Rasmussen-Torvik, David J. Cronkite, David J. Cronkite, G. Hripcsak, N. Cox, R. Wilke, C. Stein, J. Rotter, Y. Momozawa, D. Roden, R. Krauss, J. Denny   +33 more
semanticscholar   +1 more source

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co‐Oligomerized with β‐Amyloid 1‐42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids

Advanced Science, EarlyView.
Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan, Zhimeng Tang, Yanyu Luo, Bin Liu, Xinxin Huang, Jun Wei, Feng Yue   +6 more
wiley   +1 more source

Enhancing adult hippocampal neurogenesis with lysophosphatidic acid: a proposal for erasing cocaine contextual memory [PDF]

, 2018
Stimulating adult hippocampal neurogenesis (AHN) has been uncovered as a promising approach in the manipulation of retrograde memories. This work aims to study whether increasing AHN with lysophosphatidic acid (LPA, an endogenous lysophospholipid with ...
Castilla Ortega, María Estela, Estivill-Torrús, Guillermo, Gil Rodríguez, Sara, Ladrón de Guevara-Miranda, David, Moreno-Fernández, Román D., Pavón, Francisco Javier, Rodríguez de Fonseca, Fernando, Rosell-del-Valle, Cristina, Santin-Nuñez, Luis Javier, Serrano, Antonia   +9 more
core  

Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype

Journal of Neuroinflammation, 2017
BackgroundExtracellular lysophosphatidic acid (LPA) species transmit signals via six different G protein-coupled receptors (LPAR1–6) and are indispensible for brain development and function of the nervous system.
I. Plastira, E. Bernhart, M. Goeritzer, T. Devaney, H. Reicher, A. Hammer, B. Lohberger, A. Wintersperger, B. Zucol, W. F. Graier, D. Kratky, E. Malle, W. Sattler   +12 more
semanticscholar   +1 more source

Spatially Resolved Multiomics Reveals Metabolic Remodeling and Autophagy Activation in Adamantinomatous Craniopharyngiomas

Advanced Science, EarlyView.
Multiomics integration analysis reveals the “cystic fluid–tumor cell” metabolic coupling that mediates active choline/ethanolamine uptake of tumor cells from cystic fluid and PC/PE synthesis pathways reprogramming that mediating autophagy pathway activation within ACP. ABSTRACT Adamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and
Dongting Chen, Yahui Gao, Yulin Wang, Ting Lei, Zheng Qu, Yuhan An, Jiaxu Fu, Xin Li, Fangjun Liu, Yan Li   +9 more
wiley   +1 more source

Local Edge Betweenness based Label Propagation for Community Detection in Complex Networks

, 2017
Nowadays, identification and detection community structures in complex networks is an important factor in extracting useful information from networks.
Bagheri, Alireza, Shahrivari, Hamid
core   +1 more source

LPA signaling is regulated through the primary cilium: a novel target in glioblastoma

Oncogene, 2017
The primary cilium is a ubiquitous organelle presented on most human cells. It is a crucial signaling hub for multiple pathways including growth factor and G-protein coupled receptors. Loss of primary cilia, observed in various cancers, has been shown to
Yuriy V. Loskutov, Caryn L. Griffin, Kristina M. Marinak, A. Bobko, N. Margaryan, W. Geldenhuys, J. Sarkaria, E. Pugacheva   +7 more
semanticscholar   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Workplace safety behaviors in the context of selected employee and organizational factors: a latent profile analysis

Medycyna Pracy
Background This study aimed to identify distinct employee and organizational profiles influencing workplace safety behaviors (compliance and participation) using latent profile analysis (LPA), focusing on psychological need satisfaction, work performance,
Łukasz Kapica, Andrzej Najmiec, Witold Sygocki   +2 more
doaj   +1 more source

Autotaxin–lysophosphatidic acid–LPA 3 signaling at the embryo‐epithelial boundary controls decidualization pathways

EMBO Journal, 2017
During pregnancy, up‐regulation of heparin‐binding (HB‐) EGF and cyclooxygenase‐2 (COX‐2) in the uterine epithelium contributes to decidualization, a series of uterine morphological changes required for placental formation and fetal development. Here, we
S. Aikawa, K. Kano, A. Inoue, Jiao Wang, D. Saigusa, T. Nagamatsu, Yasushi Hirota, T. Fujii, Soken Tsuchiya, Y. Taketomi, Y. Sugimoto, M. Murakami, M. Arita, M. Kurano, H. Ikeda, Y. Yatomi, J. Chun, J. Aoki   +17 more
semanticscholar   +1 more source