Results 1 to 10 of about 12,929 (212)

Lsd1 restricts the number of germline stem cells by regulating multiple targets in escort cells. [PDF]

PLoS Genetics, 2014
Specialized microenvironments called niches regulate tissue homeostasis by controlling the balance between stem cell self-renewal and the differentiation of stem cell daughters.
Susan Eliazer, Victor Palacios, Zhaohui Wang, Rahul K Kollipara, Ralf Kittler, Michael Buszczak   +5 more
doaj   +3 more sources

The kinase NEK6 positively regulates LSD1 activity and accumulation in local chromatin sub-compartments. [PDF]

Commun Biol
LSD1 plays a crucial role in mammalian biology, regulated through interactions with coregulators and post-translational modifications. Here we show that the kinase NEK6 stimulates LSD1 activity in cells and observe a strong colocalization of NEK6 and ...
Knodel F, Eirich J, Pinter S, Eisler SA, Finkemeier I, Rathert P.   +5 more
europepmc   +2 more sources

LSD1+8a is an RNA biomarker of neuroendocrine prostate cancer. [PDF]

Neoplasia
Background: Lysine-specific demethylase 1 (LSD1) is a histone demethylase and regulator of differentiation, including in cancer. A neuronal-specific isoform of LSD1—LSD1+8a—has been shown to play a key role in promoting neuronal differentiation in the ...
Kumaraswamy A, Mannan R, Swaim OA, Rodansky E, Wang XM, Udager A, Mehra R, Li H, Morrissey C, Corey E, Haffner MC, Nelson PS, Chinnaiyan AM, Yates JA, Alumkal JJ.   +14 more
europepmc   +2 more sources

Cooperative role of LSD1 and CHD7 in regulating differentiation of mouse embryonic stem cells. [PDF]

Sci Rep
Lysine-specific histone demethylase 1 (LSD1) is a histone demethylase that plays a critical role in epigenetic regulation by removing the methyl group from mono- and di-methylated lysine 4 on histone H3 (H3K4me1/2), acting as a repressor of gene ...
Malla S, Martinez-Gamero C, Kumari K, Achour C, Mermelekas G, Martinez-Delgado D, Coego A, Guallar D, Roman AC, Aguilo F.   +9 more
europepmc   +2 more sources

LSD1 deficiency in breast cancer cells promotes the formation of pre-metastatic niches. [PDF]

NPJ Precis Oncol
Lysine-specific demethylase 1 (LSD1), a histone demethylating enzyme, plays a crucial role in cancer metastasis. Studies show LSD1 knockout promotes breast cancer lung metastasis, but it’s unknown if it alters the lung microenvironment for metastasis. In
Yao Y, Qian R, Gao H, Dai Y, Shi Y, An P, Xin B, Liu Z, Zhang N, Wan Y, He Y, Hu X.   +11 more
europepmc   +2 more sources

ZebraShare: a new venue for rapid dissemination of zebrafish mutant data [PDF]

PeerJ, 2021
Background In the past decade, the zebrafish community has widely embraced targeted mutagenesis technologies, resulting in an abundance of mutant lines.
April DeLaurier, Douglas G. Howe, Leyla Ruzicka, Adam N. Carte, Lacie Mishoe Hernandez, Kali J Wiggins, Mika M. Gallati, Kayce Vanpelt, Frances Loyo Rosado, Katlin G. Pugh, Chasey J. Shabdue, Khadijah Jihad, Summer B. Thyme, Jared C. Talbot   +13 more
doaj   +2 more sources

The scaffolding function of LSD1 controls DNA methylation in mouse ESCs. [PDF]

Nat Commun
Lysine-specific histone demethylase 1 (LSD1), which demethylates mono- or di- methylated histone H3 on lysine 4 (H3K4me1/2), is essential for early embryogenesis and development.
Malla S, Kumari K, García-Prieto CA, Caroli J, Nordin A, Phan TTT, Bhattarai DP, Martinez-Gamero C, Dorafshan E, Stransky S, Álvarez-Errico D, Saiki PA, Lai W, Lyu C, Lizana L, Gilthorpe JD, Wang H, Sidoli S, Mateus A, Lee DF, Cantù C, Esteller M, Mattevi A, Roman AC, Aguilo F.   +24 more
europepmc   +2 more sources

Comparison of pharmacological inhibitors of lysine-specific demethylase 1 in glioblastoma stem cells reveals inhibitor-specific efficacy profiles

Frontiers in Neurology, 2023
IntroductionImproved therapies for glioblastoma (GBM) are desperately needed and require preclinical evaluation in models that capture tumor heterogeneity and intrinsic resistance seen in patients.
Lea M. Stitzlein, Lea M. Stitzlein, Achintyan Gangadharan, Leslie M. Walsh, Deokhwa Nam, Alexsandra B. Espejo, Melissa M. Singh, Kareena H. Patel, Yue Lu, Xiaoping Su, Ravesanker Ezhilarasan, Joy Gumin, Sanjay Singh, Erik Sulman, Frederick F. Lang, Joya Chandra, Joya Chandra, Joya Chandra   +17 more
doaj   +1 more source

OTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis, and Breast Cancer Metastasis

Advanced Science, 2021
Genomic amplification of OTUD7B is frequently found across human cancers. But its role in tumorigenesis is poorly understood. Lysine‐specific demethylase 1 (LSD1) is known to execute epigenetic regulation by forming corepressor complex with CoREST ...
Zhicheng Gong, Aicun Li, Jiancheng Ding, Qing Li, Lei Zhang, Yuanpei Li, Zhe Meng, Fei Chen, Jialiang Huang, Dawang Zhou, Ronggui Hu, Jing Ye, Wen Liu, Han You   +13 more
doaj   +1 more source

Sanguinarine, identified as a natural alkaloid LSD1 inhibitor, suppresses lung cancer cell growth and migration [PDF]

Iranian Journal of Basic Medical Sciences, 2022
Objective(s): Lysine-specific demethylase1 (LSD1), an important class of histone demethylases, plays a crucial role in regulation of mammalian biology. The up-regulated LSD1 expression was frequently associated with progress and oncogenesis of multiple ...
Ting-ting Qin, Zhong-hua Li, Li-xin Li, Kun Du, Ji-ge Yang, Zhenqiang Zhang, Xiang-xiang Wu, Jinlian Ma   +7 more
doaj   +1 more source