The dual role of LSD1 and HDAC3 in STAT5-dependent transcription is determined by protein interactions, binding affinities, motifs and genomic positions [PDF]
, 2016 STAT5 interacts with other factors to control transcription, and the mechanism of regulation is of interest as constitutive active STAT5 has been reported in malignancies. Here, LSD1 and HDAC3 were identified as novel STAT5a interacting partners in pro-B
Aikaterini Nanou +7 more
openalex +6 more sources
412 Synergistic Targeting of Lysine-specific demethylase 1 (LSD1) and MAPK Signaling: A Mechanism-Guided Therapeutic Approach for Glioblastoma (GBM) [PDF]
Journal of Clinical and Translational ScienceOBJECTIVES/GOALS: LSD1 is a histone demethylase important in GBM regulation. Our goal is to design a therapeutic strategy for LSD1 inhibitors to meet clinical needs in GBM. Despite the abundance of LSD1 inhibitors, resistance emerges in GBM mouse models.
Lea Stitzlein +8 more
doaj +2 more sources
Lysine‐specific demethylase 1 deletion reshapes tumour microenvironment to overcome acquired resistance to anti‐programmed death 1 therapy in liver cancer [PDF]
Clinical and Translational MedicineBackground Immune checkpoint blockade, particularly targeting programmed death 1 (PD‐1) and programmed death ligand 1 (PD‐L1), shows promise in treating hepatocellular carcinoma (HCC).
Chen Liang +23 more
doaj +2 more sources
ZebraShare: a new venue for rapid dissemination of zebrafish mutant data [PDF]
PeerJ, 2021 Background In the past decade, the zebrafish community has widely embraced targeted mutagenesis technologies, resulting in an abundance of mutant lines.
April DeLaurier +13 more
doaj +2 more sources
Frontiers in Neurology, 2023 IntroductionImproved therapies for glioblastoma (GBM) are desperately needed and require preclinical evaluation in models that capture tumor heterogeneity and intrinsic resistance seen in patients.
Lea M. Stitzlein +17 more
doaj +1 more source
Advanced Science, 2021 Genomic amplification of OTUD7B is frequently found across human cancers. But its role in tumorigenesis is poorly understood. Lysine‐specific demethylase 1 (LSD1) is known to execute epigenetic regulation by forming corepressor complex with CoREST ...
Zhicheng Gong +13 more
doaj +1 more source
Genome-Wide Studies of Histone Demethylation Catalysed by the Fission Yeast Homologues of Mammalian LSD1 [PDF]
, 2007 In order to gain a more global view of the activity of histone demethylases, we report here genome-wide studies of the fission yeast SWIRM and polyamine oxidase (PAO) domain homologues of mammalian LSD1. Consistent with previous work we find that the two
Abdelhalim Boukaba +48 more
core +12 more sources
Integrative analysis reveals histone demethylase LSD1 promotes RNA polymerase II pausing
iScience, 2022 Summary: Lysine-specific demethylase 1 (LSD1) is well-known for its role in decommissioning enhancers during mouse embryonic stem cell (ESC) differentiation.
Hani Jieun Kim +5 more
doaj +1 more source
LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development. [PDF]
, 2020 Developmental progression depends on temporally defined changes in gene expression mediated by transient exposure of lineage intermediates to signals in the progenitor niche.
Benner, Christopher W +14 more
core +2 more sources
Over-expression of LSD1 promotes proliferation, migration and invasion in non-small cell lung cancer. [PDF]
PLoS ONE, 2012 BACKGROUND: Lysine specific demethylase 1 (LSD1) has been identified and biochemically characterized in epigenetics, but the pathological roles of its dysfunction in lung cancer remain to be elucidated.
Tangfeng Lv +6 more
doaj +1 more source