Results 1 to 10 of about 27,519 (289)

Priming with LSD1 inhibitors promotes the persistence and antitumor effect of adoptively transferred T cells

Nature Communications
The antitumor efficacy of adoptively transferred T cells is limited by their poor persistence, in part due to exhaustion, but the underlying mechanisms and potential interventions remain underexplored.
Fengqi Qiu, Peishan Jiang, Guiheng Zhang, Jie An, Kexin Ruan, Xiaowen Lyu, Jianya Zhou, Wanqiang Sheng   +7 more
semanticscholar   +1 more source

Targeting LSD1 in tumor immunotherapy: rationale, challenges and potential

Frontiers in Immunology, 2023
Lysine-specific demethylase 1 (LSD1) is an enzyme that removes lysine methylation marks from nucleosome histone tails and plays an important role in cancer initiation, progression, metastasis, and recurrence.
L. Bao, Ping Zhu, Yuan Mou, Yinhong Song, Ye Qin   +4 more
semanticscholar   +1 more source

HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency. [PDF]

, 2017
Most studies of HIV latency focus on the peripheral population of resting memory T cells, but the brain also contains a distinct reservoir of HIV-infected cells in microglia, perivascular macrophages, and astrocytes.
Alvarez-Carbonell, David, Cannon, Paula M, Chateau, Morgan, Karn, Jonathan, Llewellyn, George N   +4 more
core   +1 more source

LSD1 inhibition improves efficacy of adoptive T cell therapy by enhancing CD8+ T cell responsiveness

bioRxiv, 2023
The lysine-specific histone demethylase 1A (LSD1) has been described to play a role in antitumor immunity; however, the role of LSD1 in shaping CD8+ T cell (CTL) differentiation and function is not understood.
I. Pallavicini, T. Frasconi, Elena Ceccaci, S. Tiberti, Carina B. Nava Lauson, Elisa Preto, Alberto Bigogno, Marta Mangione, Eleonora Sala, Matteo Iannacone, M. Kuka, Luigi Nezi, S. Minucci, Teresa Manzo   +13 more
semanticscholar   +1 more source

Protein degradation of Lsd1 is mediated by Bre1 yet opposed by Lsd1-interacting lncRNAs during fly follicle development

iScience
Summary: Tissue development, homeostasis, and repair all require efficient progenitor expansion. Lysine-specific demethylase 1 (Lsd1) maintains plastic epigenetic states to promote progenitor proliferation while overexpressed Lsd1 protein causes ...
Chun Ting Lin, Ruei-Teng Ting, Yang-Hsuan Ou, Tzu-Ling Shao, Ming-Chia Lee   +4 more
doaj   +1 more source

Fluorinated tranylcypromine analogues as inhibitors of lysine-specific demethylase 1 (LSD1, KDM1A) [PDF]

, 2017
We report a series of tranylcypromine analogues containing a fluorine in the cyclopropyl ring. A number of compounds with additional m- or p- substitution of the aryl ring were micromolar inhibitors of the LSD1 enzyme.
Al-Jamal, Wafa T., Bartels, Katharina, Benelkebir, Hanae, Borrello, Maria Teresa, Douglas, Leon, Duriez, Patrick J., Ganesan, A., Haufe, Günter, Packham, Graham, Pereira, Sara, Schinor, Benjamin   +10 more
core   +2 more sources

LSD1 defines the fiber type-selective responsiveness to environmental stress in skeletal muscle

eLife, 2023
Skeletal muscle exhibits remarkable plasticity in response to environmental cues, with stress-dependent effects on the fast-twitch and slow-twitch fibers.
Hirotaka Araki, Shinjiro Hino, Kotaro Anan, Kanji Kuribayashi, Kan Etoh, D. Seko, Ryuta Takase, Kensaku Kohrogi, Yuko Hino, Y. Ono, E. Araki, M. Nakao   +11 more
semanticscholar   +1 more source

Exploration of 5-cyano-6-phenylpyrimidin derivatives containing an 1,2,3-triazole moiety as potent FAD-based LSD1 inhibitors

Acta Pharmaceutica Sinica B, 2020
Histone lysine specific demethylase 1 (LSD1) has become a potential therapeutic target for the treatment of cancer. Discovery and develop novel and potent LSD1 inhibitors is a challenge, although several of them have already entered into clinical trials.
Liying Ma, Haojie Wang, Yinghua You, Chaoya Ma, Yuejiao Liu, Feifei Yang, Yichao Zheng, Hongmin Liu   +7 more
doaj   +1 more source

Epigenomic Regulation of Androgen Receptor Signaling: Potential Role in Prostate Cancer Therapy. [PDF]

, 2017
Androgen receptor (AR) signaling remains the major oncogenic pathway in prostate cancer (PCa). Androgen-deprivation therapy (ADT) is the principle treatment for locally advanced and metastatic disease.
Cucchiara, Vito, Evans, Christopher P, Gao, Allen C, Mirone, Vincenzo, Rosenfeld, Michael G, Yang, Joy C   +5 more
core   +2 more sources

LSD1 is required for euchromatic origin firing and replication timing [PDF]

, 2022
Yue Wang, Yunchao Huang, Kwang‐Ting Cheng, Xinhua Liu, Yu Zhang, Jianguo Yang, Jordan T.F. Young, Grant W. Brown, Xiaohan Yang, Yongfeng Shang   +9 more
openalex   +1 more source