Results 21 to 30 of about 11,397 (98)
Histone H3 peptide based LSD1-selective inhibitors
Bioorganic & Medicinal Chemistry Letters, 2015 A series of candidates for the histone H3 peptide based LSD1-selective inhibitor were designed and synthesized. Among peptides 1a-c and 2a-c, peptide 1a, which has a phenylcyclopropylamine (PCPA) moiety at Lys-4 of the 21 amino acid residues of histone H3, was the most potent LSD1-selective inhibitor.
Taeko, Kakizawa +4 more
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PLoS ONE, 2013 Cholesterol 7α-hydroxylase (CYP7A1) catalyzes the first and rate-limiting step in the classical pathway of bile acids synthesis in liver and is crucial for maintaining lipid homeostasis. Hepatocyte nuclear factor 4α (HNF4α) and α1-fetoprotein transcription factor (FTF) are two major transcription factors driving CYP7A1 promoter activity in hepatocytes.
Huafang Ouyang +4 more
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LSD1 is required for chromosome segregation during mitosis
European Journal of Cell Biology, 2010 Dynamic methylation/demethylation of histones and non-histone proteins occurs during the cell cycle. Lysine-specific demethylase 1 (LSD1) exhibits diverse transcriptional activities through catalyzing demethylation of mono- and di-methylated histone H3 on lysine 4 (H3K4) and lysine 9 (H3K9).
Shuang, Lv +8 more
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Strategies that regulate LSD1 for novel therapeutics
Acta Pharmaceutica Sinica BHistone methylation plays crucial roles in regulating chromatin structure and gene transcription in epigenetic modifications. Lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, is universally overexpressed in various diseases.
Meng Li +7 more
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The precise spatiotemporal regulation of gene expression is essential for all aspects of cellular function. Dysregulation of gene transcription can lead to serious pathologies, including severe malignancies and ultimately cell death. Consequently, complex regulatory mechanisms are essential to maintain and adapt gene expression in response to internal ...
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Correction to “Reversible Lysine Specific Demethylase 1 (LSD1) Inhibitors: A Promising Wrench to Impair LSD1” [PDF]
Journal of Medicinal Chemistry, 2021 Xing-Jie Dai +6 more
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GSK-LSD1, an LSD1 inhibitor, quashes SARS-CoV-2-triggered cytokine release syndrome in-vitro
Signal Transduction and Targeted Therapy, 2020 Hong, Kyung Soo +6 more
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