Results 21 to 30 of about 27,519 (289)

The scaffolding function of LSD1 controls DNA methylation in mouse ESCs

Nature Communications
Lysine-specific histone demethylase 1 (LSD1), which demethylates mono- or di- methylated histone H3 on lysine 4 (H3K4me1/2), is essential for early embryogenesis and development.
Sandhya Malla, Kanchan Kumari, Carlos A. García-Prieto, Jonatan Caroli, Anna Nordin, Trinh T. T. Phan, Devi Prasad Bhattarai, Carlos Martinez-Gamero, Eshagh Dorafshan, Stephanie Stransky, Damiana Álvarez-Errico, Paulina Avovome Saiki, Weiyi Lai, Cong Lyu, Ludvig Lizana, Jonathan D. Gilthorpe, Hailin Wang, Simone Sidoli, Andre Mateus, Dung-Fang Lee, Claudio Cantù, Manel Esteller, Andrea Mattevi, Angel-Carlos Roman, Francesca Aguilo   +24 more
doaj   +2 more sources

Novel dual LSD1/HDAC6 inhibitor for the treatment of cancer

PLoS ONE, 2023
Dually targeting the epigenetic proteins lysine specific demethylase 1 (LSD1) and histone deacetylases (HDACs) that play a key role in cancer cells by modulating gene repressor complexes including CoREST will have a profound effect in inhibiting tumour ...
Chandru Gajendran, Subramanyam J. Tantry, Naveen Sadhu M., Mohammed Zainuddin, Purushottam Dewang, Mahanandeesha S. Hallur, Sreekala Nair, Krishnakumar Vaithilingam, Basavaprabhu Nagayya, Sridharan Rajagopal, Sivanandhan Dhanalakshmi   +10 more
openalex   +3 more sources

412 Synergistic Targeting of Lysine-specific demethylase 1 (LSD1) and MAPK Signaling: A Mechanism-Guided Therapeutic Approach for Glioblastoma (GBM) [PDF]

Journal of Clinical and Translational Science
OBJECTIVES/GOALS: LSD1 is a histone demethylase important in GBM regulation. Our goal is to design a therapeutic strategy for LSD1 inhibitors to meet clinical needs in GBM. Despite the abundance of LSD1 inhibitors, resistance emerges in GBM mouse models.
Lea Stitzlein, Jack Adams, Matthew Luetzen, Melissa Singh, Xioaping Su, Yue Lu, Joy Gumin, Frederick Lang, Joya Chandra   +8 more
doaj   +2 more sources

ZebraShare: a new venue for rapid dissemination of zebrafish mutant data [PDF]

PeerJ, 2021
Background In the past decade, the zebrafish community has widely embraced targeted mutagenesis technologies, resulting in an abundance of mutant lines.
April DeLaurier, Douglas G. Howe, Leyla Ruzicka, Adam N. Carte, Lacie Mishoe Hernandez, Kali J Wiggins, Mika M. Gallati, Kayce Vanpelt, Frances Loyo Rosado, Katlin G. Pugh, Chasey J. Shabdue, Khadijah Jihad, Summer B. Thyme, Jared C. Talbot   +13 more
doaj   +2 more sources

OTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis, and Breast Cancer Metastasis

Advanced Science, 2021
Genomic amplification of OTUD7B is frequently found across human cancers. But its role in tumorigenesis is poorly understood. Lysine‐specific demethylase 1 (LSD1) is known to execute epigenetic regulation by forming corepressor complex with CoREST ...
Zhicheng Gong, Aicun Li, Jiancheng Ding, Qing Li, Lei Zhang, Yuanpei Li, Zhe Meng, Fei Chen, Jialiang Huang, Dawang Zhou, Ronggui Hu, Jing Ye, Wen Liu, Han You   +13 more
doaj   +1 more source

Comparison of pharmacological inhibitors of lysine-specific demethylase 1 in glioblastoma stem cells reveals inhibitor-specific efficacy profiles

Frontiers in Neurology, 2023
IntroductionImproved therapies for glioblastoma (GBM) are desperately needed and require preclinical evaluation in models that capture tumor heterogeneity and intrinsic resistance seen in patients.
Lea M. Stitzlein, Lea M. Stitzlein, Achintyan Gangadharan, Leslie M. Walsh, Deokhwa Nam, Alexsandra B. Espejo, Melissa M. Singh, Kareena H. Patel, Yue Lu, Xiaoping Su, Ravesanker Ezhilarasan, Joy Gumin, Sanjay Singh, Erik Sulman, Frederick F. Lang, Joya Chandra, Joya Chandra, Joya Chandra   +17 more
doaj   +1 more source

LSD1: Biologic Roles and Therapeutic Targeting [PDF]

Epigenomics, 2016
LSD1 (KDM1A; BHC110; AOF2) was the first protein reported to exhibit histone demethylase activity and has since been shown to have multiple essential roles in mammalian biology. Given its enzymatic activity and its high-level expression in many human malignancies, a significant recent focus has been the development of pharmacologic inhibitors.
Maiques-Diaz, Alba, Somervaille, Tim Cp
openaire   +3 more sources

Genome-Wide Studies of Histone Demethylation Catalysed by the Fission Yeast Homologues of Mammalian LSD1 [PDF]

, 2007
In order to gain a more global view of the activity of histone demethylases, we report here genome-wide studies of the fission yeast SWIRM and polyamine oxidase (PAO) domain homologues of mammalian LSD1. Consistent with previous work we find that the two
Abdelhalim Boukaba, Antony M. Carr, BG Mellone, C Martin, Carolina Bonilla, D Robyr, David Lando, E Metzger, E Nicolas, Ernest D. Laue, G Rigaut, GW Humphrey, I Sinha, IM Hall, J Bahler, J Nakayama, James Cauwood, JF Flanagan, JJ Tasto, Juan Valcarcel, Julian Walfridsson, K Noma, K Yamane, Karl Ekwall, M Wiren, MA Hakimi, MG Lee, MG Lee, Michael Opel, MJ Buck, Natalia V. Murzina, P Bjerling, PA Cloos, Petra J.H. Werler, PJ Werler, R Schneider, RJ Klose, RJ Sims 3rd, Robin C. Allshire, Sarah C. Trewick, SI Grewal, SK Kurdistani, Tony Kouzarides, U Kleeberg, Y Shi, Y Shi, Y Tsukada, Y Xue, YJ Shi   +48 more
core   +12 more sources

Integrative analysis reveals histone demethylase LSD1 promotes RNA polymerase II pausing

iScience, 2022
Summary: Lysine-specific demethylase 1 (LSD1) is well-known for its role in decommissioning enhancers during mouse embryonic stem cell (ESC) differentiation.
Hani Jieun Kim, Pishun Li, Taiyun Kim, Andrew J. Oldfield, Xiaofeng Zheng, Pengyi Yang   +5 more
doaj   +1 more source

LSD1 inhibitors for cancer treatment: Focus on multi-target agents and compounds in clinical trials

Frontiers in Pharmacology, 2023
Histone lysine-specific demethylase 1 (LSD1/KDM1A) was first identified in 2004 as an epigenetic enzyme able to demethylate specific lysine residues of histone H3, namely H3K4me1/2 and H3K9me1/2, using FAD as the cofactor.
Beatrice Noce, Elisabetta Di Bello, R. Fioravanti, A. Mai   +3 more
semanticscholar   +1 more source