Results 31 to 40 of about 27,519 (289)

LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development. [PDF]

, 2020
Developmental progression depends on temporally defined changes in gene expression mediated by transient exposure of lineage intermediates to signals in the progenitor niche.
Benner, Christopher W, Geusz, Ryan J, Harrington, Austin R, Jhala, Ulupi S, Matta, Ileana, Patel, Nisha A, Rosenfeld, Michael G, Sander, Maike, Shih, Hung-Ping, Vinckier, Nicholas K, Wang, Allen, Wang, Jianxun, Wang, Jinzhao, Wetton, Nichole, Wortham, Matthew   +14 more
core   +2 more sources

Histone Demethylase LSD1 Regulates Adipogenesis [PDF]

Journal of Biological Chemistry, 2010
Epigenetic mechanisms, in particular the enzymatic modification of histones, are a crucial element of cell differentiation, a regulated process that allows a precursor cell basically to turn into a different cell type while maintaining the same genetic equipment.
Melina M, Musri, Mari Carmen, Carmona, Felicia A, Hanzu, Perla, Kaliman, Ramon, Gomis, Marcelina, Párrizas   +5 more
openaire   +2 more sources

Over-expression of LSD1 promotes proliferation, migration and invasion in non-small cell lung cancer. [PDF]

PLoS ONE, 2012
BACKGROUND: Lysine specific demethylase 1 (LSD1) has been identified and biochemically characterized in epigenetics, but the pathological roles of its dysfunction in lung cancer remain to be elucidated.
Tangfeng Lv, Dongmei Yuan, Xiaohui Miao, Yanling Lv, Ping Zhan, Xiaokun Shen, Yong Song   +6 more
doaj   +1 more source

LSD1 Promotes Prostate Cancer Cell Survival by Destabilizing FBXW7 at Post-Translational Level

Frontiers in Oncology, 2021
Prostate cancer (PCa) is the most common cancer in men and the fifth leading cause of cancer death worldwide. Unfortunately, castration-resistant prostate cancer (CRPCa) is incurable with surgical treat and prone to drug resistance.
Xu-ke Qin, Yang Du, Xiu-heng Liu, Lei Wang   +3 more
doaj   +1 more source

Alternative splicing of LSD1+8a in neuroendocrine prostate cancer is mediated by SRRM4

Neoplasia: An International Journal for Oncology Research, 2020
Neuroendocrine prostate cancer (NEPC) is the most virulent form of prostate cancer. Importantly, our recent work examining metastatic biopsy samples demonstrates NEPC is increasing in frequency.
Daniel J. Coleman, David A. Sampson, Archana Sehrawat, Anbarasu Kumaraswamy, Duanchen Sun, Yuzhuo Wang, Jacob Schwartzman, Joshua Urrutia, Ahn R. Lee, Ilsa M. Coleman, Peter S. Nelson, Xuesen Dong, Colm Morrissey, Eva Corey, Zheng Xia, Joel A. Yates, Joshi J. Alumkal   +16 more
doaj   +1 more source

Sanguinarine, identified as a natural alkaloid LSD1 inhibitor, suppresses lung cancer cell growth and migration [PDF]

Iranian Journal of Basic Medical Sciences, 2022
Objective(s): Lysine-specific demethylase1 (LSD1), an important class of histone demethylases, plays a crucial role in regulation of mammalian biology. The up-regulated LSD1 expression was frequently associated with progress and oncogenesis of multiple ...
Ting-ting Qin, Zhong-hua Li, Li-xin Li, Kun Du, Ji-ge Yang, Zhenqiang Zhang, Xiang-xiang Wu, Jinlian Ma   +7 more
doaj   +1 more source

E3 ligase Trim35 inhibits LSD1 demethylase activity through K63-linked ubiquitination and enhances anti-tumor immunity in NSCLC

Cell Reports, 2023
Summary: Targeting lysine-specific histone demethylase 1A (LSD1) can improve tumor immunogenicity of poorly immunogenic tumors, such as non-small cell lung cancer (NSCLC), with elevated T cell infiltration and sensitize tumors to anti-PD-1 therapy ...
Feiyu Tang, Can Lu, Xiang He, Wei Lin, Bowen Xie, Xing Gao, Yang Peng, Desong Yang, Lunquan Sun, Liang Weng   +9 more
doaj   +1 more source

LSD1/KDM1 isoform LSD1+8a contributes to neural differentiation in small cell lung cancer [PDF]

Biochemistry and Biophysics Reports, 2017
Small cell lung cancer (SCLC) is an aggressive neuroendocrine tumor characterized by rapid progression. The mechanisms that lead to a shift from initial therapeutic sensitivity to ultimate therapeutic resistance are poorly understood. Although the SCLC genomic landscape led to the discovery of promising agents targeting genetic alterations that were ...
Takanobu Jotatsu, Shigehiro Yagishita, Ken Tajima, Fumiyuki Takahashi, Kaoru Mogushi, Moulid Hidayat, Aditya Wirawan, Ryo Ko, Ryota Kanemaru, Naoko Shimada, Keiko Mitani, Tsuyoshi Saito, Kazuya Takamochi, Kenji Suzuki, Shinji Kohsaka, Shinya Kojima, Hiroshi Mukae, Kazuhiro Yatera, Kazuhisa Takahashi   +18 more
openaire   +5 more sources

Visualizing the Histone Code on LSD1 [PDF]

Cell, 2007
In this issue, Garcia-Bassets et al. (2007) show that spurious transcriptional activation by unliganded nuclear receptors is inhibited by histone lysine methylation. This inhibitory histone modification code is efficiently countered by the ligand-dependent recruitment of histone lysine demethylases, including lysine-specific demethylase 1 (LSD1), which
Gamble, Matthew J., Kraus, W. Lee
openaire   +2 more sources

The enzymes LSD1 and Set1A cooperate with the viral protein HBx to establish an active hepatitis B viral chromatin state [PDF]

, 2016
Indexación: Web of ScienceWith about 350 million people chronically infected around the world hepatitis B is a major health problem. Template for progeny HBV synthesis is the viral genome, organized as a minichromosome (cccDNA) inside the hepatocyte ...
Alarcon, V, Alvarez, F, De Ferrari, GV, Flores, Y, Hernandez, S, Kann, M, Loyola, A, Rubio, L, Varas-Godoy, M, Villanueva, RA   +9 more
core   +2 more sources