Epigenetics in ovarian cancer: premise, properties, and perspectives. [PDF]
, 2018 Malignant ovarian tumors bear the highest mortality rate among all gynecological cancers. Both late tumor diagnosis and tolerance to available chemical therapy increase patient mortality.
Huang, Shuang +16 more
core +2 more sources
Gene regulation and epigenotype in Friedreich's ataxia [PDF]
, 2008 Friedreich??????s ataxia (FRDA) is known to be provoked by an abnormal GAA-repeat expansion located in the first intron of the FXN gene. As a result of the GAA expansion, patients exhibit low levels of FXN mRNA, leading to FRDA.
Rothe, Nadine, Rothe, Nadine
core +2 more sources
The dual role of LESION SIMULATING DISEASE 1 as a condition-dependent scaffold protein and transcription regulator [PDF]
, 2017 Since its discovery over two decades ago as an important cell death regulator in Arabidopsis thaliana, the role of LESION SIMULATING DISEASE 1 (LSD1) has been studied intensively within both biotic and abiotic stress responses as well as with respect to ...
Balazadeh, Salma +9 more
core +2 more sources
Community-aware network sparsification [PDF]
, 2017 Network sparsification aims to reduce the number of edges of a network while maintaining its structural properties; such properties include shortest paths, cuts, spectral measures, or network modularity. Sparsification has multiple applications, such as,
Gionis, Aristides +3 more
core +2 more sources
LSD1: Expanding Functions in Stem Cells and Differentiation [PDF]
Cells, 2021 Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSC) provide a powerful model system to uncover fundamental mechanisms that control cellular identity during mammalian development. Histone methylation governs gene expression programs that play a key role in the regulation of the balance between self-renewal and differentiation of ESCs ...
Carlos Martinez-Gamero +2 more
openaire +4 more sources
LSD1 inhibition attenuates androgen receptor V7 splice variant activation in castration resistant prostate cancer models [PDF]
, 2018 Background: Castrate resistant prostate cancer (CRPC) is often driven by constitutively active forms of the androgen receptor such as the V7 splice variant (AR-V7) and commonly becomes resistant to established hormonal therapy strategies such as ...
A. Ganesan +48 more
core +2 more sources
LSD1 Histone Demethylase Assays and Inhibition [PDF]
, 2016 The lysine-specific demethylase (LSD1) is a flavin-dependent amine oxidase that selectively removes one or two methyl groups from histone H3 at the Lys4 position. Along with histone deacetylases 1 and 2, LSD1 is involved in epigenetically silencing gene expression. LSD1 has been implicated as a potential therapeutic target in cancer and other diseases.
D, Hayward, P A, Cole
openaire +2 more sources
Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features [PDF]
, 2016 Because of its involvement in the progression of several malignant tumors, the histone lysine-specific demethylase 1 (LSD1) has become a prominent drug target in modern medicinal chemistry research.
Ciossani, Giuseppe +11 more
core +2 more sources
The Deubiquitinase USP28 Stabilizes LSD1 and Confers Stem-Cell-like Traits to Breast Cancer Cells
Cell Reports, 2013 LSD1 is a critical chromatin modulator that controls cellular pluripotency and differentiation through the demethylation of H3K4me1/2. Overexpression of LSD1 has been observed in many types of tumors and is correlated with its oncogenic effects in ...
Yadi Wu +7 more
doaj +1 more source
Methylated DNMT1 and E2F1 Are Targeted for Proteolysis by L3MBTL3 and CRL4DCAF5 Ubiquitin Ligase [PDF]
, 2018 Many non-histone proteins are lysine methylated and a novel function of this modification is to trigger the proteolysis of methylated proteins. Here, we report that the methylated lysine 142 of DNMT1, a major DNA methyltransferase that preserves ...
Alejo, Salvador +7 more
core +3 more sources