Results 61 to 70 of about 3,794 (236)

A Biomimetic Total Synthesis of Clivonine

, 2011
The first chapter of this thesis discusses the biomimetic total synthesis of clivonine. Clivonine is a member of the Amaryllidaceae family of alkaloids and was isolated from the plant Clivia miniata Regel by Wildman in 1956.
Paddock, Victoria L., Paddock, Victoria L.   +1 more
core   +1 more source

Amaryllidaceae alkaloid cherylline inhibits the replication of dengue and Zika viruses [PDF]

, 2021
Dengue fever, caused by dengue virus (DENV), is the most prevalent arthropod- borne viral disease and is endemic in many tropical and subtropical parts of the world, with an increasing incidence in temperate regions.
Berthoux L., Chatel-Chaix L., Desgagne-Penix I., Di Lecce R., Evidente A., Ka S., Landelouci K., Masi M., Merindol N., Pepin G., Plourde M. B., Seck M., Singh A., Sow A. A.   +13 more
core   +1 more source

TDP‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models

The FEBS Journal, Volume 293, Issue 2, Page 348-384, January 2026.
The manuscript explores structural and functional features of TDP‐43 and its worm homologue, TDP‐1, highlighting conserved and divergent structural and functional features. Using genetically engineered C. elegans models, key pathological features of TDP‐43 proteinopathies—including aggregation, neurodegeneration, and motor deficits—are recapitulated ...
Ghulam Jeelani Pir, Joerg Buddenkotte, Majid Ali Alam, Ahmed Own, Randall J. Eck, Brian C. Kraemer, Eckhard Mandelkow, Martin Steinhoff   +7 more
wiley   +1 more source

Steroid Alkaloids from Holarrhena africana with Strong Activity against Trypanosoma brucei rhodesiense [PDF]

, 2017
In our continued search for natural compounds with activity against Trypanosoma brucei, causative agent of human African trypanosomiasis (HAT, "sleeping sickness"), we have investigated extracts from the leaves and bark of the West African ...
Brun, Reto, Kaiser, Marcel, Nnadi, Charles Okeke, Nwodo, Ngozi Justina, Schmidt, Thomas J.   +4 more
core   +2 more sources

Environmental and phytohormone modulation of organ‐specific specialized metabolite profiles in the dryland tree Erythrina velutina

Plant Biology, Volume 27, Issue 7, Page 1326-1340, December 2025.
Erythrina velutina organ‐specific specialized metabolism is modulated by environmental stress and phytohormones to mitigate effects of the harsh semi‐arid habitat. Abstract Erythrina velutina is a tree that thrives in the shallow rocky soils of the dry and hot Caatinga, a unique Brazilian biome.
D. S. Chacon, B. Bonilauri, C. T. da Costa, J. Vilasboa, M. Koetz, L. Pinto, J. A. S. Zuanazzi, R. B. Giordani, A. G. Fett‐Neto   +8 more
wiley   +1 more source

Study on apoptosis effect of human breast cancer cell MCF-7 induced by lycorine hydrochloride via death receptor pathway

Saudi Pharmaceutical Journal, 2017
As research was conducted on the early apoptosis of human breast cancer cell MCF-7 caused by lycorine hydrochloride and the expression of the related apoptosis proteins.
Yubin Ji, Miao Yu, Zheng Qi, Di Cui, Guosong Xin, Bing Wang, Weiling Jia, Lin Chang   +7 more
doaj   +1 more source

Cytotoxicity of Elaoephorbia drupifera and other Cameroonian medicinal plants against drug sensitive and multidrug resistant cancer cells [PDF]

, 2013
BACKGROUND: Multidrug resistance (MDR) is a major hurdle for cancer treatment worldwide and accounts for chemotherapy failure in over 90% of patients with metastatic cancer.
Armelle T Mbaveng, Benjamin Wiench, Igor K Voukeng, Roger Tsobou, Thomas Efferth, Veronique P Beng, Victor Kuete   +6 more
core   +1 more source

Preclinical Screening Platform Identifies Azatadine‐Dimaleate as a Potent Repurposed Therapeutic Against SARS‐CoV‐2 Infection

Journal of Medical Virology, Volume 97, Issue 11, November 2025.
ABSTRACT The emergence of SARS‐CoV‐2 posed a major global public health threat, necessitating urgent development of therapeutics. Despite vaccine availability, continuous emergence of viral variants with enhanced transmissibility and immune escape capabilities, and consequential impacts on health services, requires effective antiviral therapeutics ...
Ahlam Ali, David Courtney, Lindsay Broadbent, Parul Sharma, Connor G. G. Bamford, Sheerien Manzoor, Olivier Touzelet, Conall McCaughey, Adam Kirby, Eleanor Bentley, Anja Kipar, Ken I. Mills, James P. Stewart, Ultan F. Power   +13 more
wiley   +1 more source

Lycorine impedes 7,12-dimethylbenz(a)anthracene exposed hamster oral carcinogenesis through P13K/Akt and NF-κB inhibition

Türk Biyokimya Dergisi, 2022
Oncogenic signaling pathways that are activated abnormally play a key activity in tumor initiation and development. This research aimed to examine the preventive efficiency of lycorine in the buccal pouch hamster tumor model based on its capacity to ...
Gan Yi, He Ai’e, Zhu Lilei, Yao Yao, Lv Chunhua   +4 more
doaj   +1 more source

Exploration of Lycorine and Copper(II)’s Association with the N-Terminal Domain of Amyloid β

Inorganics, 2023
Lycorine (LYC) is an active alkaloid first isolated from Narcissus pseudonarcissus and found in most Amaryllidaceae plants. It belongs to the same family as galantamine, which is the active component of a drug used for the treatment of Alzheimer’s ...
Arian Kola, Ginevra Vigni, Daniela Valensin   +2 more
doaj   +1 more source