Results 1 to 10 of about 30,355 (264)

Spatio-temporal Models of Lymphangiogenesis in Wound Healing [PDF]

arXiv, 2016
Several studies suggest that one possible cause of impaired wound healing is failed or insufficient lymphangiogenesis, that is the formation of new lymphatic capillaries. Although many mathematical models have been developed to describe the formation of blood capillaries (angiogenesis), very few have been proposed for the regeneration of the lymphatic ...
A Bianchi, A Castiglioni, A Christiansen, A Friedman, A Gosiewska, A Louveau, A Mantovani, A Saaristo, A Stéphanou, AB Sutton, AI Papaioannou, AJ Macdonald, AJ Singer, Arianna Bianchi, AV Benest, AW Taylor, AY Sheikh, B Greenwood, B Kaminska, B Whitehurst, BE Farrell, BM Berg van den, C Cao, C Heppell, C Norrmen, CA Cobbold, CH Cho, CL Helm, CT Ambrose, D Ludwig, DJ Grainger, DR Brown, E Hormbrey, E Mendoza, EK Rofstad, ETT Withington, F Krombach, F Mac Gabhann, G Crescenzo De, G Müller, G Oliver, GF Pierce, GJ Goodhill, H Brem, H Kaur, H Staden von, HA Levine, HM Byrne, HM Byrne, HV Waugh, I Barkefors, I Choi, I Nunes, I Zachary, J Asai, J Goldman, J Posnett, JA Flegg, JC Zhuang, JD Shields, JF Douglas, JJL Velázquez, JJL Velázquez, JM Rutkowski, JM Rutkowski, Jonathan A. Sherratt, JP Yang, K Maruyama, K Weber-Matthiesen, KC Boardman, KE Murphy, Kevin J. Painter, KN Margaris, L Edelstein, L Yang, LM Wakefield, M Fischer, M Hyytiäinen, M Lohela, M Oi, M Scianna, M Shi, MAJ Chaplain, ME Fleury, ME Swift, MH Witte, MTGT May, N Khalil, N Khalil, N Li Jeon, NP Reddy, NV Mantzaris, P Drew, P Galie, PN Bernatchez, R Boulton, R Huggenberger, RC Ji, RC Schugart, RH Adams, RS Sweat, RT Tranquillo, S Kiriakidis, S Lee, S Monstrey, S Podgrabinska, S Zimny, SJ Lunt, SM Wahl, T Miura, T Roose, T Tammela, TG Simonsen, TL Haas, VPKH Nguyen, WJ Jeffcoate, Y Cao, Y Zheng   +117 more
arxiv   +3 more sources

A Mathematical Model for Lymphangiogenesis in Normal and Diabetic Wounds [PDF]

arXiv, 2015
Several studies suggest that one possible cause of impaired wound healing is failed or insufficient lymphangiogenesis, that is the formation of new lymphatic capillaries. Although many mathematical models have been developed to describe the formation of blood capillaries (angiogenesis) very few have been proposed for the regeneration of the lymphatic ...
Bianchi, Arianna, Painter, Kevin J., Sherratt, Jonathan A.   +2 more
arxiv   +3 more sources

Does plasminogen activator inhibitor-1 drive lymphangiogenesis? [PDF]

PLoS ONE, 2010
The purpose of this study is to explore the function of plasminogen activator inhibitor-1 (PAI-1) during pathological lymphangiogenesis. PAI-1, the main physiological inhibitor of plasminogen activators is involved in pathological angiogenesis at least ...
Françoise Bruyère, Laurence Melen-Lamalle, Silvia Blacher, Benoît Detry, Anne Masset, Julie Lecomte, Vincent Lambert, Catherine Maillard, Gunilla Høyer-Hansen, Leif R Lund, Jean-Michel Foidart, Agnès Noël   +11 more
doaj   +6 more sources

Targeting glycolytic reprogramming by tsRNA-0032 for treating pathological lymphangiogenesis [PDF]

Cell Death and Disease
Lymphangiogenesis is vital for tissue fluid homeostasis, immune function, and lipid absorption. Abnormal lymphangiogenesis has been implicated in several diseases such as cancers, inflammatory, and autoimmune diseases.
Fan Ye, Ziran Zhang, Lianjun Shi, Shuting Lu, Xiumiao Li, Wan Mu, Qin Jiang, Biao Yan   +7 more
doaj   +2 more sources

Integrins and Their Extracellular Matrix Ligands in Lymphangiogenesis and Lymph Node Metastasis [PDF]

International Journal of Cell Biology, 2012
In the 1970s, the late Judah Folkman postulated that tumors grow proportionately to their blood supply and that tumor angiogenesis removed this limitation promoting growth and metastasis. Work over the past 40 years, varying from molecular examination to
Jie Chen, J. Steven Alexander, A. Wayne Orr   +2 more
doaj   +4 more sources

SOAT1 Activates NLRP3 Inflammasome to Promote Cancer-Related Lymphangiogenesis and Metastasis via IL-1β/IL-1R-1 Axis in Oral Squamous Cell Carcinoma. [PDF]

Mol Carcinog
ABSTRACT Oral squamous cell carcinoma (OSCC) is a prevalent type of cancer in the head and neck region, significantly impacting patient survival rates and quality of life. Lymph node (LN) metastasis is a lead contributor to the poor prognosis associated with OSCC.
Zhao C, Wang Y, Jiang Z, Guo S, Hu L, Pan J, Dan F.   +6 more
europepmc   +2 more sources

Negative regulation of lymphangiogenesis by Tenascin-C delays the resolution of inflammation [PDF]

iScience
Summary: Lymphatic vessels are required for the clearance of excess fluid and immune cells from inflamed tissue, making the regulation of lymphangiogenesis an important area of research.
Daisuke Katoh, Yoshiyuki Senga, Kento Mizutani, Kazuaki Maruyama, Daishi Yamakawa, Tadashi Yamamuro, Michiaki Hiroe, Keiichi Yamanaka, Akihiro Sudo, Naoyuki Katayama, Toshimichi Yoshida, Kyoko Imanaka-Yoshida   +11 more
doaj   +2 more sources

Lymphangiogenesis is required for pancreatic islet inflammation and diabetes. [PDF]

PLoS ONE, 2011
Lymphangiogenesis is a common phenomenon observed during inflammation and engraftment of transplants, but its precise role in the immune response and underlying mechanisms of regulation remain poorly defined. Here we showed that in response to injury and
Na Yin, Nan Zhang, Girdhari Lal, Jiangnan Xu, Minhong Yan, Yaozhong Ding, Jonathan S Bromberg   +6 more
doaj   +5 more sources

The immune regulatory role of lymphangiogenesis in kidney disease [PDF]

Journal of Translational Medicine
The renal lymphatic system is critical for maintaining kidney homeostasis and regulating the immune response inside the kidney. In various kidney pathological situations, the renal lymphatic network experiences lymphangiogenesis, which is defined as the ...
Xiangheng Lu, Kuai Ma, Junyi Ren, Haoyu Peng, Jia Wang, Xiaoxiao Wang, Moussa Ide Nasser, Chi Liu   +7 more
doaj   +2 more sources

Hormone Receptor-Dependent Correlations Between Angiopoietins and VEGF-C in Primary Breast Cancer: Insights Into Lymphangiogenic Biomarkers. [PDF]

Cancer Rep (Hoboken)
ABSTRACT Background Biomarkers of angiogenesis and lymphangiogenesis have been explored in cancer prognostic models; however, their potential role in assessing local tumor invasiveness remains poorly understood. Aims This study aimed to evaluate the correlations of angiogenic biomarkers, specifically the angiopoietin (ANG)‐Tie system and vascular ...
Montazeri V, Varshosaz P, Fakhrjou A, Pirouzpanah S.   +3 more
europepmc   +2 more sources