Results 1 to 10 of about 36,407 (187)

Three-dimensional modelling of lymphangiogenesis in-vitro using bioorthogonal click-crosslinked gelatin hydrogels [PDF]

Materials Today Bio
Lymphangiogenesis, the formation of new lymphatic vessels from pre-existing vessels, is crucial for maintaining tissue homeostasis and immune function. Despite recent advances in understanding the molecular mechanisms regulating lymphangiogenesis, most ...
Dana E. Al-Ansari, Yangshuo Hu, Nicola Contessi Negrini, Daisy Jones, Graeme M. Birdsey, Adam D. Celiz   +5 more
doaj   +3 more sources

Lymphangiogenesis Guidance Mechanisms and Therapeutic Implications in Pathological States of the Cornea [PDF]

Cells, 2023
Corneal lymphangiogenesis is one component of the neovascularization observed in several inflammatory pathologies of the cornea including dry eye disease and corneal graft rejection.
Mehul Patnam, Sunil R. Dommaraju, Faisal Masood, Paula Herbst, Jin-Hong Chang, Wen-Yang Hu, Mark I. Rosenblatt, Dimitri T. Azar   +7 more
doaj   +2 more sources

Lymphangiogenesis induced by vascular endothelial growth factor receptor 1 signaling contributes to the progression of endometriosis in mice

Journal of Pharmacological Sciences, 2020
Lymphangiogenesis is related to the growth of endometriosis. Here, we examined whether vascular endothelial growth factor (VEGF) receptor 1 (VEGFR1) signaling plays a role in lymphangiogenesis during endometriosis.
Kyoko Hattori, Yoshiya Ito, Masako Honda, Kazuki Sekiguchi, Kanako Hosono, Masabumi Shibuya, Nobuya Unno, Masataka Majima   +7 more
doaj   +2 more sources

Lymphangiogenesis: from the pig embryos to cancer [PDF]

, 2008
The discovery and the comprehension of lymphatic vessels suffered several historical delays and setbacks. The inherent anatomical problems slowed down the precise identification of the lymphatic system during the development of medical science.
Duarte, Maria, Longatto Filho, Adhemar, Schmitt, Fernando C.   +2 more
core   +5 more sources

Lymphatic Endothelial Markers and Tumor Lymphangiogenesis Assessment in Human Breast Cancer

Diagnostics, 2021
Metastasis via lymphatic vessels or blood vessels is the leading cause of death for breast cancer, and lymphangiogenesis and angiogenesis are critical prerequisites for the tumor invasion–metastasis cascade.
Jia-Mei Chen, Bo Luo, Ru Ma, Xi-Xi Luo, Yong-Shun Chen, Yan Li   +5 more
doaj   +1 more source

High endogenous CCL2 expression promotes the aggressive phenotype of human inflammatory breast cancer

Nature Communications, 2021
Inflammatory breast cancer (IBC) is an aggressive form of breast cancer with a poor prognosis. Here the authors report the characterization of a human IBC cell line recapitulating the clinical and histopathological features of the human disease, and ...
Anita Rogic, Ila Pant, Luca Grumolato, Ruben Fernandez-Rodriguez, Andrew Edwards, Suvendu Das, Aaron Sun, Shen Yao, Rui Qiao, Shabnam Jaffer, Ravi Sachidanandam, Guray Akturk, Rosa Karlic, Mihaela Skobe, Stuart A. Aaronson   +14 more
doaj   +1 more source

Activation of Dll4/Notch Signaling and Hypoxia-Inducible Factor-1 Alpha Facilitates Lymphangiogenesis in Lacrimal Glands in Dry Eye. [PDF]

PLoS ONE, 2016
By using hypoxia-inducible factor-1 alpha conditional knockout (HIF-1α CKO) mice and a dry eye (DE) mouse model, we aimed to determine the role played by delta-like ligand 4 (Dll4)/Notch signaling and HIF-1α in the lymphangiogenesis of lacrimal glands ...
Ji Hwan Min, Chul Hee Lee, Yong Woo Ji, Areum Yeo, Hyemi Noh, Insil Song, Eung Kweon Kim, Hyung Keun Lee   +7 more
doaj   +1 more source

Reactive Oxygen Species in Regulating Lymphangiogenesis and Lymphatic Function

Cells, 2022
The lymphatic system is pivotal for immunosurveillance and the maintenance of tissue homeostasis. Lymphangiogenesis, the formation of new lymphatic vessels from pre-existing vessels, has both physiological and pathological roles.
Bhupesh Singla, Ravi Varma Aithabathula, Sonia Kiran, Shweta Kapil, Santosh Kumar, Udai P. Singh   +5 more
doaj   +1 more source

Cancer-associated fibroblast-derived SOD3 enhances lymphangiogenesis to drive metastasis in lung adenocarcinoma. [PDF]

Angiogenesis
Oo MW, Hikita T, Mashima T, Torigata K, Thu YM, Habu T, Kawai H, Ohara T, Tomida S, Ito S, Suzawa K, Nagatsuka H, Toyooka S, Nakayama M.   +13 more
europepmc   +3 more sources

Identification of Gene Expression Differences between Lymphangiogenic and Non-Lymphangiogenic Non-Small Cell Lung Cancer Cell Lines. [PDF]

PLoS ONE, 2016
It is well established that lung tumors induce the formation of lymphatic vessels. However, the molecular mechanisms controlling tumor lymphangiogenesis in lung cancer have not been fully delineated. In the present study, we identify a panel of non-small
Erin Regan, Robert C Sibley, Bercin Kutluk Cenik, Asitha Silva, Luc Girard, John D Minna, Michael T Dellinger   +6 more
doaj   +1 more source