Results 1 to 10 of about 17,508 (126)
Lymphangiogenesis and Anti-lymphangiogenesis in Cutaneous Melanoma [PDF]
Anticancer Research, 2016 Cutaneous malignant melanoma is an aggressive tumor characterized by early lymph node metastasis and bad prognosis. Although the spread of tumor cells in the regional lymph nodes is very important in the staging, prognosis and therapeutic strategy of malignant melanoma, the mechanism(s) of initial lymphatic vessels invasion is are) not completely ...
Marius, Raica +2 more
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Lymphangiogenesis and Cancer [PDF]
Genes & Cancer, 2011 Historically, lymphatic vessels were considered passive participants in tumor metastasis by simply providing channels for tumor cells to transit to draining lymph nodes. The discovery of several key lymphatic-specific molecular markers and an increased availability of in vitro and in vivo experimental systems to study lymphatic biology have however ...
Christiansen A, Detmar M
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Computational and Mathematical Methods in Medicine, 2003 While much effort is given to the modelling of tumour angiogenesis, little attention is paid to lymphangiogenesis and its potential role in tumour progression and metastasis. This is due at least in part to the controversy that surrounds tumour lymphangiogenesis—opinion is divided as to whether tumours actively promote the development of lymph channels
Catherine R. Tait, Pamela F. Jones
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Lymphangiogenesis and tumor metastasis [PDF]
Thrombosis and Haemostasis, 2003 SummaryIn several human cancers, increased expression in primary tumors of vascular endothelial growth factor-C (VEGF-C) is correlated with regional lymph node metastasis. Studies using transgenic mice overexpressing VEGF-C, or xenotransplantation of VEGF-C-expressing tumor cells into immunodeficient mice, have demonstrated a role for VEGF-C in tumor ...
Riccardo E, Nisato +2 more
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Myeloid Cells and Lymphangiogenesis [PDF]
Cold Spring Harbor Perspectives in Medicine, 2012 The lymphatic vascular system and the hematopoietic system are intimately connected in ontogeny and in physiology. During embryonic development, mammalian species derive a first lymphatic vascular plexus from the previously formed anterior cardinal vein, whereas birds and amphibians have a lymphatic vascular system of dual origin, composed of lymphatic
Zumsteg, Adrian, Christofori, Gerhard
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Circulation, 2012 At the level of the capillaries, the systemic circulation loses about 2-4 liters of fluid and about 100g of protein into the interstitium daily. This ultrafiltrate of the systemic capillaries is returned to the circulatory system by the lymphatics. The lymphatic vasculature is highly specialized to perform this service, beginning with the blind-ended ...
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Lymphangiogenesis and cancer metastasis [PDF]
Journal of Cellular and Molecular Medicine, 2009 Abstract Anatomy and function of the lymphatic system Tumour‐induced lymphangiogenesis promotes metastasis Tumour‐induced lymph node lymphangiogenesis precedes cancer metastasis to lymph nodes Tumour cell invasion into lymphatic vessels Peri‐ and intra‐tumoral lymphangiogenesis Lymphatic vessel markers and lymphangiogenic growth factors Preventive and ...
Mumprecht, Viviane, Detmar, Michael
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Growth Hormone Promotes Lymphangiogenesis [PDF]
The American Journal of Pathology, 2008 The lymphatic system plays an important role in inflammation and cancer progression, although the molecular mechanisms involved are poorly understood. As determined using comparative transcriptional profiling studies of cultured lymphatic endothelial cells versus blood vascular endothelial cells, growth hormone receptor was expressed at much higher ...
Nadja Erika, Banziger-Tobler +3 more
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Lymphangiogenesis and cancer metastasis
Frontiers in Bioscience, 2011 Lymphangiogenesis remains a fascinating biological process that plays a crucial role in both normal tissue development and several lymphatic diseases. The last few years have witnessed a rapid progression in understanding the development and regulation of the lymphatic system which provided insight on several pathological processes including cancer ...
Mahir A A, Al-Rawi, Wen G, Jiang
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Lymphedema and Therapeutic Lymphangiogenesis
BioMed Research International, 2013 Lymphedema is a disorder of the lymphatic vascular system characterized by impaired lymphatic return and swelling of the extremities. Lymphedema is divided into primary and secondary forms based on the underlying etiology. Despite substantial advances in both surgical and conservative techniques, therapeutic options for the management of lymphedema are
Yukihiro Saito +3 more
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