Reactive Oxygen Species in Regulating Lymphangiogenesis and Lymphatic Function
Cells, 2022 The lymphatic system is pivotal for immunosurveillance and the maintenance of tissue homeostasis. Lymphangiogenesis, the formation of new lymphatic vessels from pre-existing vessels, has both physiological and pathological roles.
Bhupesh Singla +5 more
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Lymphangiogenesis in gastric cancer: function and mechanism
European Journal of Medical Research, 2023 Increased lymphangiogenesis and lymph node (LN) metastasis are thought to be important steps in cancer metastasis, and are associated with patient's poor prognosis.
Pengpeng Liu +6 more
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Lymphatic Endothelial Markers and Tumor Lymphangiogenesis Assessment in Human Breast Cancer
Diagnostics, 2021 Metastasis via lymphatic vessels or blood vessels is the leading cause of death for breast cancer, and lymphangiogenesis and angiogenesis are critical prerequisites for the tumor invasion–metastasis cascade.
Jia-Mei Chen +5 more
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Three-dimensional modelling of lymphangiogenesis in-vitro using bioorthogonal click-crosslinked gelatin hydrogels [PDF]
Materials Today BioLymphangiogenesis, the formation of new lymphatic vessels from pre-existing vessels, is crucial for maintaining tissue homeostasis and immune function. Despite recent advances in understanding the molecular mechanisms regulating lymphangiogenesis, most ...
Dana E. Al-Ansari +5 more
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Targeting glycolytic reprogramming by tsRNA-0032 for treating pathological lymphangiogenesis [PDF]
Cell Death and DiseaseLymphangiogenesis is vital for tissue fluid homeostasis, immune function, and lipid absorption. Abnormal lymphangiogenesis has been implicated in several diseases such as cancers, inflammatory, and autoimmune diseases.
Fan Ye +7 more
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Nature Communications, 2021 Inflammatory breast cancer (IBC) is an aggressive form of breast cancer with a poor prognosis. Here the authors report the characterization of a human IBC cell line recapitulating the clinical and histopathological features of the human disease, and ...
Anita Rogic +14 more
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Activation of Dll4/Notch Signaling and Hypoxia-Inducible Factor-1 Alpha Facilitates Lymphangiogenesis in Lacrimal Glands in Dry Eye. [PDF]
PLoS ONE, 2016 By using hypoxia-inducible factor-1 alpha conditional knockout (HIF-1α CKO) mice and a dry eye (DE) mouse model, we aimed to determine the role played by delta-like ligand 4 (Dll4)/Notch signaling and HIF-1α in the lymphangiogenesis of lacrimal glands ...
Ji Hwan Min +7 more
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Identification of Gene Expression Differences between Lymphangiogenic and Non-Lymphangiogenic Non-Small Cell Lung Cancer Cell Lines. [PDF]
PLoS ONE, 2016 It is well established that lung tumors induce the formation of lymphatic vessels. However, the molecular mechanisms controlling tumor lymphangiogenesis in lung cancer have not been fully delineated. In the present study, we identify a panel of non-small
Erin Regan +6 more
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Does plasminogen activator inhibitor-1 drive lymphangiogenesis? [PDF]
PLoS ONE, 2010 The purpose of this study is to explore the function of plasminogen activator inhibitor-1 (PAI-1) during pathological lymphangiogenesis. PAI-1, the main physiological inhibitor of plasminogen activators is involved in pathological angiogenesis at least ...
Françoise Bruyère +11 more
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Podoplanin immunopositive lymphatic vessels at the implant interface in a rat model of osteoporotic fractures [PDF]
, 2013 Insertion of bone substitution materials accelerates healing of osteoporotic fractures. Biodegradable materials are preferred for application in osteoporotic patients to avoid a second surgery for implant replacement. Degraded implant fragments are often
Alt, Volker +16 more
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