Effects of adenosine on lymphangiogenesis. [PDF]
PLoS ONE, 2014 BACKGROUND: The lymphatic system controls tissue homeostasis by draining protein-rich lymph to the vascular system. Lymphangiogenesis, the formation of lymphatic vessels, is a normal event in childhood but promotes tumor spread and metastasis during ...
Bénédicte Lenoir +6 more
doaj +6 more sources
EphrinB2-mediated CDK5/ISL1 pathway enhances cardiac lymphangiogenesis and alleviates ischemic injury by resolving post-MI inflammation [PDF]
Signal Transduction and Targeted TherapyEphrinB2 (erythropoietin-producing hepatoma interactor B2) is a key Eph/ephrin family member, promoting angiogenesis, vasculogenesis, and lymphangiogenesis during embryonic development. However, the role of EphrinB2 in cardiac lymphangiogenesis following
Yingnan Bai +19 more
doaj +2 more sources
Lymphatics and Lymphangiogenesis in the Eye [PDF]
Journal of Ophthalmology, 2012 Lymphatic is a prerequisite for the maintenance of tissue fluid balance and immunity in the body. A body of evidence also shows that lymphangiogenesis plays important roles in the pathogenesis of diseases such as tumor metastasis and inflammation.
Shintaro Nakao +2 more
doaj +5 more sources
CEACAM1 increased the lymphangiogenesis through miR-423-5p and NF- kB in Non-Small Cell Lung Cancer [PDF]
Biochemistry and Biophysics ReportsBackground: Lung cancer causes significant mortality, with invasion and metastasis being the main features that cause most cancer deaths. Lymph node metastasis is the primary metastatic route in non-small cell carcinoma (NSCLC) and influences the staging
Jie Yu +9 more
doaj +2 more sources
A zebrafish model of inflammatory lymphangiogenesis [PDF]
Biology Open, 2015 Inflammatory bowel disease (IBD) is a disabling chronic inflammatory disease of the gastrointestinal tract. IBD patients have increased intestinal lymphatic vessel density and recent studies have shown that this may contribute to the resolution of IBD ...
Kazuhide S. Okuda +9 more
doaj +5 more sources
Lymphatic‐specific methyltransferase‐like 3‐mediated m6A modification drives vascular patterning through prostaglandin metabolism reprogramming [PDF]
MedCommLymphangiogenesis plays a pivotal role in the pathogenesis of various vascular disorders, including ocular vascular diseases and cancers. Deregulation of N6‐methyladenosine (m6A) modification has been identified as a key contributor to human diseases ...
Lianjun Shi +7 more
doaj +2 more sources
Lymphatic Endothelial Markers and Tumor Lymphangiogenesis Assessment in Human Breast Cancer
Diagnostics, 2021 Metastasis via lymphatic vessels or blood vessels is the leading cause of death for breast cancer, and lymphangiogenesis and angiogenesis are critical prerequisites for the tumor invasion–metastasis cascade.
Jia-Mei Chen +5 more
doaj +1 more source
Nature Communications, 2021 Inflammatory breast cancer (IBC) is an aggressive form of breast cancer with a poor prognosis. Here the authors report the characterization of a human IBC cell line recapitulating the clinical and histopathological features of the human disease, and ...
Anita Rogic +14 more
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Activation of Dll4/Notch Signaling and Hypoxia-Inducible Factor-1 Alpha Facilitates Lymphangiogenesis in Lacrimal Glands in Dry Eye. [PDF]
PLoS ONE, 2016 By using hypoxia-inducible factor-1 alpha conditional knockout (HIF-1α CKO) mice and a dry eye (DE) mouse model, we aimed to determine the role played by delta-like ligand 4 (Dll4)/Notch signaling and HIF-1α in the lymphangiogenesis of lacrimal glands ...
Ji Hwan Min +7 more
doaj +1 more source
Lymphangiogenesis and Anti-lymphangiogenesis in Cutaneous Melanoma [PDF]
Anticancer Research, 2016 Cutaneous malignant melanoma is an aggressive tumor characterized by early lymph node metastasis and bad prognosis. Although the spread of tumor cells in the regional lymph nodes is very important in the staging, prognosis and therapeutic strategy of malignant melanoma, the mechanism(s) of initial lymphatic vessels invasion is are) not completely ...
Marius Raica +2 more
openaire +3 more sources