Results 11 to 20 of about 23,756 (251)

Effects of adenosine on lymphangiogenesis. [PDF]

PLoS ONE, 2014
BACKGROUND: The lymphatic system controls tissue homeostasis by draining protein-rich lymph to the vascular system. Lymphangiogenesis, the formation of lymphatic vessels, is a normal event in childhood but promotes tumor spread and metastasis during ...
Bénédicte Lenoir, Daniel R Wagner, Silvia Blacher, Graciela B Sala-Newby, Andrew C Newby, Agnès Noel, Yvan Devaux   +6 more
doaj   +6 more sources

Lymphatics and Lymphangiogenesis in the Eye [PDF]

Journal of Ophthalmology, 2012
Lymphatic is a prerequisite for the maintenance of tissue fluid balance and immunity in the body. A body of evidence also shows that lymphangiogenesis plays important roles in the pathogenesis of diseases such as tumor metastasis and inflammation.
Shintaro Nakao, Ali Hafezi-Moghadam, Tatsuro Ishibashi   +2 more
doaj   +5 more sources

A zebrafish model of inflammatory lymphangiogenesis [PDF]

Biology Open, 2015
Inflammatory bowel disease (IBD) is a disabling chronic inflammatory disease of the gastrointestinal tract. IBD patients have increased intestinal lymphatic vessel density and recent studies have shown that this may contribute to the resolution of IBD ...
Kazuhide S. Okuda, June Pauline Misa, Stefan H. Oehlers, Christopher J. Hall, Felix Ellett, Sultan Alasmari, Graham J. Lieschke, Kathryn E. Crosier, Philip S. Crosier, Jonathan W. Astin   +9 more
doaj   +5 more sources

ALKBH5 activates FAK signaling through m6A demethylation in ITGB1 mRNA and enhances tumor-associated lymphangiogenesis and lymph node metastasis in ovarian cancer

Theranostics, 2023
Background: Lymph node (LN) metastasis is common in patients with epithelial ovarian cancer (EOC) and is associated with poor prognosis. Tumor-associated lymphangiogenesis is the first stage of LN metastasis.
Rui Sun, Lin Yuan, Yi Jiang, Y. Wan, Xiaolling Ma, Jing Yang, Guodong Sun, Shulin Zhou, Hui Wang, Jiangnan Qiu, Lin Zhang, Wenjun Cheng   +11 more
semanticscholar   +1 more source

Promotion of Lymphangiogenesis by Targeted Delivery of VEGF-C Improves Diabetic Wound Healing

Cells, 2023
Chronic wounds represent a major therapeutic challenge. Lymphatic vessel function is impaired in chronic ulcers but the role of lymphangiogenesis in wound healing has remained unclear. We found that lymphatic vessels are largely absent from chronic human
L. Brunner, Yuliang He, N. Cousin, Jeannette Scholl, Livia K. Albin, B. Schmucki, S. Supersaxo, G. Restivo, J. Hafner, D. Neri, Sabine Werner, M. Detmar   +11 more
semanticscholar   +1 more source

High endogenous CCL2 expression promotes the aggressive phenotype of human inflammatory breast cancer

Nature Communications, 2021
Inflammatory breast cancer (IBC) is an aggressive form of breast cancer with a poor prognosis. Here the authors report the characterization of a human IBC cell line recapitulating the clinical and histopathological features of the human disease, and ...
Anita Rogic, Ila Pant, Luca Grumolato, Ruben Fernandez-Rodriguez, Andrew Edwards, Suvendu Das, Aaron Sun, Shen Yao, Rui Qiao, Shabnam Jaffer, Ravi Sachidanandam, Guray Akturk, Rosa Karlic, Mihaela Skobe, Stuart A. Aaronson   +14 more
doaj   +1 more source

Current Status of Lymphangiogenesis: Molecular Mechanism, Immune Tolerance, and Application Prospect

Cancers, 2023
Simple Summary Lymphatic vessels are low-pressure, blind-ended tubular structures essential in maintaining tissue fluid homeostasis, immune cell transport, and lipid transport. More and more evidence showed that lymphangiogenesis might be closely related
Hongyang Deng, Jiaxing Zhang, Fahong Wu, Feng-xian Wei, Wei Han, Xiao-dong Xu, Youcheng Zhang   +6 more
semanticscholar   +1 more source

Activation of Dll4/Notch Signaling and Hypoxia-Inducible Factor-1 Alpha Facilitates Lymphangiogenesis in Lacrimal Glands in Dry Eye. [PDF]

PLoS ONE, 2016
By using hypoxia-inducible factor-1 alpha conditional knockout (HIF-1α CKO) mice and a dry eye (DE) mouse model, we aimed to determine the role played by delta-like ligand 4 (Dll4)/Notch signaling and HIF-1α in the lymphangiogenesis of lacrimal glands ...
Ji Hwan Min, Chul Hee Lee, Yong Woo Ji, Areum Yeo, Hyemi Noh, Insil Song, Eung Kweon Kim, Hyung Keun Lee   +7 more
doaj   +1 more source

Lymphangiogenesis and Anti-lymphangiogenesis in Cutaneous Melanoma [PDF]

Anticancer Research, 2016
Cutaneous malignant melanoma is an aggressive tumor characterized by early lymph node metastasis and bad prognosis. Although the spread of tumor cells in the regional lymph nodes is very important in the staging, prognosis and therapeutic strategy of malignant melanoma, the mechanism(s) of initial lymphatic vessels invasion is are) not completely ...
Marius Raica, Anca Maria Cimpean, Adriana-Andreea Jitariu   +2 more
openaire   +3 more sources

FASN promotes lymph node metastasis in cervical cancer via cholesterol reprogramming and lymphangiogenesis

Cell Death and Disease, 2022
Cervical cancer (CC) patients with lymph node metastasis (LNM) have a poor prognosis. Clarification of the detailed mechanisms underlying LNM may provide potential clinical therapeutic targets for CC patients with LNM. However, the molecular mechanism of
Q. Du, Pan Liu, Chunyu Zhang, Tianyu Liu, Wei Wang, C. Shang, Jieyu Wu, Y. Liao, Yili Chen, Jia-ming Huang, Hao Tan, Yun-he Zhao, M. Xia, Junxiu Liu, S. Yao   +14 more
semanticscholar   +1 more source