Results 11 to 20 of about 27,751 (253)

Lymphangiogenesis in gastric cancer: function and mechanism

European Journal of Medical Research, 2023
Increased lymphangiogenesis and lymph node (LN) metastasis are thought to be important steps in cancer metastasis, and are associated with patient's poor prognosis.
Pengpeng Liu, Ping’an Ding, Chenyu Sun, Shuya Chen, Scott Lowe, Lingjiao Meng, Qun Zhao   +6 more
doaj   +2 more sources

ETV4 Mediated Tumor‐Associated Neutrophil Infiltration Facilitates Lymphangiogenesis and Lymphatic Metastasis of Bladder Cancer

Advanced Science, 2023
As a key step of tumor lymphatic metastasis, lymphangiogenesis is regulated by VEGFC‐VEGFR3 signaling pathway mediated by immune cells, mainly macrophages, in the tumor microenvironment.
Qiang Zhang, Sen Liu, Hongjin Wang, Kanghua Xiao, Junlin Lu, Siting Chen, Ming Huang, Ruihui Xie, Tianxin Lin, Xu Chen   +9 more
doaj   +3 more sources

Reactive Oxygen Species in Regulating Lymphangiogenesis and Lymphatic Function

Cells, 2022
The lymphatic system is pivotal for immunosurveillance and the maintenance of tissue homeostasis. Lymphangiogenesis, the formation of new lymphatic vessels from pre-existing vessels, has both physiological and pathological roles.
Bhupesh Singla, Ravi Varma Aithabathula, Sonia Kiran, Shweta Kapil, Santosh Kumar, Udai P. Singh   +5 more
doaj   +2 more sources

Exosomal circ_0026611 contributes to lymphangiogenesis by reducing PROX1 acetylation and ubiquitination in human lymphatic endothelial cells (HLECs)

Cellular & Molecular Biology Letters, 2023
Background Esophageal squamous carcinoma (ESCC) is a common malignancy that originates in the digestive tract. Lymph node metastasis (LNM) is a complicated process, and tumor lymphangiogenesis has been reported to be associated with the spread of tumor ...
Wenjian Yao, Xiangbo Jia, Li Zhu, Lei Xu, Quan Zhang, Tian Xia, Li Wei   +6 more
doaj   +2 more sources

Lymphatic Endothelial Markers and Tumor Lymphangiogenesis Assessment in Human Breast Cancer

Diagnostics, 2021
Metastasis via lymphatic vessels or blood vessels is the leading cause of death for breast cancer, and lymphangiogenesis and angiogenesis are critical prerequisites for the tumor invasion–metastasis cascade.
Jia-Mei Chen, Bo Luo, Ru Ma, Xi-Xi Luo, Yong-Shun Chen, Yan Li   +5 more
doaj   +2 more sources

Effects of adenosine on lymphangiogenesis. [PDF]

PLoS ONE, 2014
BACKGROUND: The lymphatic system controls tissue homeostasis by draining protein-rich lymph to the vascular system. Lymphangiogenesis, the formation of lymphatic vessels, is a normal event in childhood but promotes tumor spread and metastasis during ...
Bénédicte Lenoir, Daniel R Wagner, Silvia Blacher, Graciela B Sala-Newby, Andrew C Newby, Agnès Noel, Yvan Devaux   +6 more
doaj   +6 more sources

PEDF inhibits lymphatic metastasis of nasopharyngeal carcinoma as a new lymphangiogenesis inhibitor

Cell Death and Disease, 2021
Nasopharyngeal carcinoma (NPC) is one of the most malignant tumors in southern China and Asia, and lymph node metastasis is an important cause for treatment failure.
Chuanghua Luo, Haofan Yin, Tianxiao Gao, Caiqi Ma, Junxi Liu, Ting Zhang, Zumin Xu, Xi Wang, Danrui Zhang, Weiwei Qi, Zhonghan Yang, Guoquan Gao, Xia Yang, Ti Zhou   +13 more
doaj   +2 more sources

Three-dimensional modelling of lymphangiogenesis in-vitro using bioorthogonal click-crosslinked gelatin hydrogels [PDF]

Materials Today Bio
Lymphangiogenesis, the formation of new lymphatic vessels from pre-existing vessels, is crucial for maintaining tissue homeostasis and immune function. Despite recent advances in understanding the molecular mechanisms regulating lymphangiogenesis, most ...
Dana E. Al-Ansari, Yangshuo Hu, Nicola Contessi Negrini, Daisy Jones, Graeme M. Birdsey, Adam D. Celiz   +5 more
doaj   +2 more sources

Role of Extracellular Vesicles on Cancer Lymphangiogenesis and Lymph Node Metastasis

Frontiers in Oncology, 2021
Lymph node metastasis (LNM) of tumors is an established indicator of poor prognosis in patients. Tumor-associated lymphangiogenesis is a key step in LNM and has gained much attention. However, currently, there is no anti-tumor lymphangiogenesis drug used
Linlin Wang, Ling Li, Guiquan Zhu
doaj   +2 more sources

Lymphatics and Lymphangiogenesis in the Eye [PDF]

Journal of Ophthalmology, 2012
Lymphatic is a prerequisite for the maintenance of tissue fluid balance and immunity in the body. A body of evidence also shows that lymphangiogenesis plays important roles in the pathogenesis of diseases such as tumor metastasis and inflammation.
Shintaro Nakao, Ali Hafezi-Moghadam, Tatsuro Ishibashi   +2 more
doaj   +5 more sources