Results 11 to 20 of about 43,762 (300)

LINC01116 , a hypoxia‐ lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma [PDF]

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Richard A. Gonçalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
openalex   +2 more sources

ALKBH5 activates FAK signaling through m6A demethylation in ITGB1 mRNA and enhances tumor-associated lymphangiogenesis and lymph node metastasis in ovarian cancer

Theranostics, 2023
Background: Lymph node (LN) metastasis is common in patients with epithelial ovarian cancer (EOC) and is associated with poor prognosis. Tumor-associated lymphangiogenesis is the first stage of LN metastasis.
Rui Sun, Lin Yuan, Yi Jiang, Y. Wan, Xiaolling Ma, Jing Yang, Guodong Sun, Shulin Zhou, Hui Wang, Jiangnan Qiu, Lin Zhang, Wenjun Cheng   +11 more
semanticscholar   +1 more source

Downregulation of miR‐100‐5p in cancer‐associated fibroblast‐derived exosomes facilitates lymphangiogenesis in esophageal squamous cell carcinoma

Cancer Medicine, 2023
Esophageal squamous cell carcinoma (ESCC), an aggressive gastrointestinal tumor, often has high early lymphatic metastatic potential. Cancer‐associated fibroblasts (CAFs) are primary components in tumor microenvironment (TME), and the impact of CAFs and ...
Chao Chen, Chenbo Yang, Xiangyu Tian, Yinghao Liang, Shuaiyuan Wang, Xiaoqian Wang, Yuwei Shou, Hui Li, Qiankun Xiao, Jiao Shu, Miaomiao Sun, Kuisheng Chen   +11 more
semanticscholar   +1 more source

FASN promotes lymph node metastasis in cervical cancer via cholesterol reprogramming and lymphangiogenesis

Cell Death and Disease, 2022
Cervical cancer (CC) patients with lymph node metastasis (LNM) have a poor prognosis. Clarification of the detailed mechanisms underlying LNM may provide potential clinical therapeutic targets for CC patients with LNM. However, the molecular mechanism of
Q. Du, Pan Liu, Chunyu Zhang, Tianyu Liu, Wei Wang, C. Shang, Jieyu Wu, Y. Liao, Yili Chen, Jia-ming Huang, Hao Tan, Yun-he Zhao, M. Xia, Junxiu Liu, S. Yao   +14 more
semanticscholar   +1 more source

High endogenous CCL2 expression promotes the aggressive phenotype of human inflammatory breast cancer

Nature Communications, 2021
Inflammatory breast cancer (IBC) is an aggressive form of breast cancer with a poor prognosis. Here the authors report the characterization of a human IBC cell line recapitulating the clinical and histopathological features of the human disease, and ...
Anita Rogic, Ila Pant, Luca Grumolato, Ruben Fernandez-Rodriguez, Andrew Edwards, Suvendu Das, Aaron Sun, Shen Yao, Rui Qiao, Shabnam Jaffer, Ravi Sachidanandam, Guray Akturk, Rosa Karlic, Mihaela Skobe, Stuart A. Aaronson   +14 more
doaj   +1 more source

CD47 Activation by Thrombospondin-1 in Lymphatic Endothelial Cells Suppresses Lymphangiogenesis and Promotes Atherosclerosis

Arteriosclerosis, Thrombosis and Vascular Biology, 2023
Background: TSP1 (thrombospondin-1)—a well-known angiogenesis inhibitor—mediates differential effects via interacting with cell surface receptors including CD36 (cluster of differentiation) and CD47.
Bhupesh Singla, Ravi Varma Aithbathula, Naveed Pervaiz, Ishita Kathuria, M. Swanson, F. Ekuban, WonMo Ahn, Frank Park, Maxwell A. Gyamfi, M. Cherian-Shaw, Udai P. Singh, Santosh Kumar   +11 more
semanticscholar   +1 more source

The role of HIF in angiogenesis, lymphangiogenesis, and tumor microenvironment in urological cancers

Molecular Biology Reports, 2023
Typically associated with solid tumors, hypoxia contributes to tumor angiogenesis and lymphangiogenesis through various molecular mechanisms. Accumulating studies indicate that hypoxia-inducible factor is the key transcription factor coordinating ...
Shen Lin, Yueyang Chai, Xiangyi Zheng, Xin Xu   +3 more
semanticscholar   +1 more source

Activation of Dll4/Notch Signaling and Hypoxia-Inducible Factor-1 Alpha Facilitates Lymphangiogenesis in Lacrimal Glands in Dry Eye. [PDF]

PLoS ONE, 2016
By using hypoxia-inducible factor-1 alpha conditional knockout (HIF-1α CKO) mice and a dry eye (DE) mouse model, we aimed to determine the role played by delta-like ligand 4 (Dll4)/Notch signaling and HIF-1α in the lymphangiogenesis of lacrimal glands ...
Ji Hwan Min, Chul Hee Lee, Yong Woo Ji, Areum Yeo, Hyemi Noh, Insil Song, Eung Kweon Kim, Hyung Keun Lee   +7 more
doaj   +1 more source

Promotion of Lymphangiogenesis by Targeted Delivery of VEGF-C Improves Diabetic Wound Healing

Cells, 2023
Chronic wounds represent a major therapeutic challenge. Lymphatic vessel function is impaired in chronic ulcers but the role of lymphangiogenesis in wound healing has remained unclear. We found that lymphatic vessels are largely absent from chronic human
L. Brunner, Yuliang He, N. Cousin, Jeannette Scholl, Livia K. Albin, B. Schmucki, S. Supersaxo, G. Restivo, J. Hafner, D. Neri, Sabine Werner, M. Detmar   +11 more
semanticscholar   +1 more source

Breaking a Vicious Circle: Lymphangiogenesis as a New Therapeutic Target in Wound Healing

Biomedicines, 2023
The lymphatic system is of fundamental importance in maintaining a fluid balance in the body and tissue homeostasis; it drains protein-rich lymph from the interstitial space and facilitates the release of cells that mediate the immune response.
F. Renó, M. Sabbatini
semanticscholar   +1 more source