Results 21 to 30 of about 43,762 (300)

Lymphangiogenesis and Anti-lymphangiogenesis in Cutaneous Melanoma [PDF]

Anticancer Research, 2016
Cutaneous malignant melanoma is an aggressive tumor characterized by early lymph node metastasis and bad prognosis. Although the spread of tumor cells in the regional lymph nodes is very important in the staging, prognosis and therapeutic strategy of malignant melanoma, the mechanism(s) of initial lymphatic vessels invasion is are) not completely ...
Marius, Raica, Adriana-Andreea, Jitariu, Anca Maria, Cimpean   +2 more
openaire   +2 more sources

Identification of Gene Expression Differences between Lymphangiogenic and Non-Lymphangiogenic Non-Small Cell Lung Cancer Cell Lines. [PDF]

PLoS ONE, 2016
It is well established that lung tumors induce the formation of lymphatic vessels. However, the molecular mechanisms controlling tumor lymphangiogenesis in lung cancer have not been fully delineated. In the present study, we identify a panel of non-small
Erin Regan, Robert C Sibley, Bercin Kutluk Cenik, Asitha Silva, Luc Girard, John D Minna, Michael T Dellinger   +6 more
doaj   +1 more source

Lymphangiogenesis and Cancer [PDF]

Genes & Cancer, 2011
Historically, lymphatic vessels were considered passive participants in tumor metastasis by simply providing channels for tumor cells to transit to draining lymph nodes. The discovery of several key lymphatic-specific molecular markers and an increased availability of in vitro and in vivo experimental systems to study lymphatic biology have however ...
Christiansen A, Detmar M
openaire   +2 more sources

Does plasminogen activator inhibitor-1 drive lymphangiogenesis? [PDF]

PLoS ONE, 2010
The purpose of this study is to explore the function of plasminogen activator inhibitor-1 (PAI-1) during pathological lymphangiogenesis. PAI-1, the main physiological inhibitor of plasminogen activators is involved in pathological angiogenesis at least ...
Françoise Bruyère, Laurence Melen-Lamalle, Silvia Blacher, Benoît Detry, Anne Masset, Julie Lecomte, Vincent Lambert, Catherine Maillard, Gunilla Høyer-Hansen, Leif R Lund, Jean-Michel Foidart, Agnès Noël   +11 more
doaj   +1 more source

Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism.

Nature Cancer, 2021
Secreted extracellular vesicles (EVs) influence the tumor microenvironment and promote distal metastasis. Here we analyzed the involvement of melanoma-secreted EVs in lymph node pre-metastatic niche formation in murine models.
S. García-Silva, A. Benito‐Martin, Laura Nogués, Alberto Hernández-Barranco, Marina S. Mazariegos, Vanesa Santos, M. Hergueta-Redondo, P. Ximénez-Embún, Raghu P. Kataru, Ana Amor López, C. Merino, S. Sánchez-Redondo, Osvaldo Graña-Castro, Irina R Matei, J. A. Nicolás-Ávila, R. Torres-Ruiz, S. Rodríguez-Perales, Lola Martínez, Manuel Pérez-Martínez, Gadea Mata, A. Szumera-Ciećkiewicz, I. Kalinowska, A. Saltari, J. Martinez-Gomez, S. Hogan, H. Saragovi, S. Ortega, C. García-Martín, J. Boskovic, M. Levesque, P. Rutkowski, A. Hidalgo, J. Muñoz, D. Megías, B. Mehrara, D. Lyden, H. Peinado   +36 more
semanticscholar   +1 more source

Current Status of Lymphangiogenesis: Molecular Mechanism, Immune Tolerance, and Application Prospect

Cancers, 2023
Simple Summary Lymphatic vessels are low-pressure, blind-ended tubular structures essential in maintaining tissue fluid homeostasis, immune cell transport, and lipid transport. More and more evidence showed that lymphangiogenesis might be closely related
Hongyang Deng, Jiaxing Zhang, Fahong Wu, Feng-xian Wei, Wei Han, Xiao-dong Xu, Youcheng Zhang   +6 more
semanticscholar   +1 more source

Cancer-associated fibroblast-derived SOD3 enhances lymphangiogenesis to drive metastasis in lung adenocarcinoma. [PDF]

Angiogenesis
Oo MW, Hikita T, Mashima T, Torigata K, Thu YM, Habu T, Kawai H, Ohara T, Tomida S, Ito S, Suzawa K, Nagatsuka H, Toyooka S, Nakayama M.   +13 more
europepmc   +3 more sources

Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression

Journal of Clinical Investigation, 2022
Vascular endothelial growth factor C (VEGF-C) induces lymphangiogenesis via VEGF receptor 3 (VEGFR3), which is encoded by the most frequently mutated gene in human primary lymphedema. Angiopoietins (Angs) and their Tie receptors regulate lymphatic vessel
E. A. Korhonen, Aino Murtomäki, S. K. Jha, A. Anisimov, A. Pink, Yan Zhang, Simon Stritt, Inam Liaqat, L. Stanczuk, Laura Alderfer, Zhiliang Sun, Emmi Kapiainen, Abhishek Singh, Ibrahim Sultan, Anni Lantta, V. Leppänen, L. Eklund, Yulong He, H. Augustin, Kari Vaahtomeri, P. Saharinen, Taija Mäkinen, K. Alitalo   +22 more
semanticscholar   +1 more source

The Role of Periostin in Angiogenesis and Lymphangiogenesis in Tumors

Cancers, 2022
Simple Summary Cancers are common diseases that affect people of all ages worldwide. For this reason, continuous attempts are being made to improve current therapeutic options.
Adrian Wasik, K. Ratajczak-Wielgomas, Arkadiusz Badzinski, P. Dzięgiel, Marzenna Podhorska-Okołów   +4 more
semanticscholar   +1 more source

KRAS mutant–driven SUMOylation controls extracellular vesicle transmission to trigger lymphangiogenesis in pancreatic cancer

Journal of Clinical Investigation, 2022
Lymph node (LN) metastasis occurs frequently in pancreatic ductal adenocarcinoma (PDAC) and predicts poor prognosis for patients. The KRASG12D mutation confers an aggressive PDAC phenotype that is susceptible to lymphatic dissemination.
Yuming Luo, Zhihua Li, Yao Kong, Wang He, Hanhao Zheng, M. An, Yan Lin, Dingwen Zhang, Jiabin Yang, Yue Zhao, Changhao Chen, Rufu Chen   +11 more
semanticscholar   +1 more source