Results 21 to 30 of about 30,187 (260)
Lymphangiogenesis and Cancer [PDF]
Genes & Cancer, 2011 Historically, lymphatic vessels were considered passive participants in tumor metastasis by simply providing channels for tumor cells to transit to draining lymph nodes. The discovery of several key lymphatic-specific molecular markers and an increased availability of in vitro and in vivo experimental systems to study lymphatic biology have however ...
Ailsa J. Christiansen, Michael Detmar
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Reactive Oxygen Species in Regulating Lymphangiogenesis and Lymphatic Function
Cells, 2022 The lymphatic system is pivotal for immunosurveillance and the maintenance of tissue homeostasis. Lymphangiogenesis, the formation of new lymphatic vessels from pre-existing vessels, has both physiological and pathological roles.
Bhupesh Singla +5 more
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Myeloid Cells and Lymphangiogenesis [PDF]
Cold Spring Harbor Perspectives in Medicine, 2012 The lymphatic vascular system and the hematopoietic system are intimately connected in ontogeny and in physiology. During embryonic development, mammalian species derive a first lymphatic vascular plexus from the previously formed anterior cardinal vein, whereas birds and amphibians have a lymphatic vascular system of dual origin, composed of lymphatic
Zumsteg, Adrian, Christofori, Gerhard
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Lipid metabolism in pancreatic cancer: emerging roles and potential targets
Cancer Communications, Volume 42, Issue 12, Page 1234-1256, December 2022., 2022 Abstract Pancreatic cancer is one of the most serious health issues in developed and developing countries, with a 5‐year overall survival rate currently <9%. Patients typically present with advanced disease due to vague symptoms or lack of screening for early cancer detection.
Xinpeng Yin +6 more
wiley +1 more source
Lymphangiogenesis and tumor metastasis [PDF]
Thrombosis and Haemostasis, 2003 SummaryIn several human cancers, increased expression in primary tumors of vascular endothelial growth factor-C (VEGF-C) is correlated with regional lymph node metastasis. Studies using transgenic mice overexpressing VEGF-C, or xenotransplantation of VEGF-C-expressing tumor cells into immunodeficient mice, have demonstrated a role for VEGF-C in tumor ...
Michael S. Pepper +2 more
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Identification of Gene Expression Differences between Lymphangiogenic and Non-Lymphangiogenic Non-Small Cell Lung Cancer Cell Lines. [PDF]
PLoS ONE, 2016 It is well established that lung tumors induce the formation of lymphatic vessels. However, the molecular mechanisms controlling tumor lymphangiogenesis in lung cancer have not been fully delineated. In the present study, we identify a panel of non-small
Erin Regan +6 more
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Lymphangiogenesis in gastric cancer: function and mechanism
European Journal of Medical Research, 2023 Increased lymphangiogenesis and lymph node (LN) metastasis are thought to be important steps in cancer metastasis, and are associated with patient's poor prognosis.
Pengpeng Liu +6 more
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Journal of Cellular and Molecular Medicine, Volume 26, Issue 23, Page 5743-5754, December 2022., 2022 Abstract Vascular endothelial growth factor‐C (VEGF‐C) binds to receptor vascular endothelial growth factor receptor‐3 (VEGFR‐3) expressed on lymphatic endothelial and melanoma cells. Binding of VEGF‐C to VEGFR‐3 enhances receptor phosphorylation that activates mitogen‐activated protein kinase (MAP‐K) and phosphatidylinositol‐3‐kinase (PI3K).
Yvette N. Hlophe, Anna M. Joubert
wiley +1 more source
Promoting inflammatory lymphangiogenesis by vascular endothelial growth factor-C (VEGF-C) aggravated intestinal inflammation in mice with experimental acute colitis [PDF]
Brazilian Journal of Medical and Biological Research, 2016 Angiogenesis and lymphangiogenesis are thought to play a role in the pathogenesis of inflammatory bowel diseases (IBD). However, it is not understood if inflammatory lymphangiogenesis is a pathological consequence or a productive attempt to resolve the ...
X.L. Wang, J. Zhao, L. Qin, M. Qiao
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PEDF inhibits lymphatic metastasis of nasopharyngeal carcinoma as a new lymphangiogenesis inhibitor
Cell Death and Disease, 2021 Nasopharyngeal carcinoma (NPC) is one of the most malignant tumors in southern China and Asia, and lymph node metastasis is an important cause for treatment failure.
Chuanghua Luo +13 more
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