Results 21 to 30 of about 27,701 (209)

The Role of Periostin in Angiogenesis and Lymphangiogenesis in Tumors

Cancers, 2022
Simple Summary Cancers are common diseases that affect people of all ages worldwide. For this reason, continuous attempts are being made to improve current therapeutic options.
Adrian Wasik, K. Ratajczak-Wielgomas, Arkadiusz Badzinski, P. Dzięgiel, Marzenna Podhorska-Okołów   +4 more
semanticscholar   +1 more source

KRAS mutant–driven SUMOylation controls extracellular vesicle transmission to trigger lymphangiogenesis in pancreatic cancer

Journal of Clinical Investigation, 2022
Lymph node (LN) metastasis occurs frequently in pancreatic ductal adenocarcinoma (PDAC) and predicts poor prognosis for patients. The KRASG12D mutation confers an aggressive PDAC phenotype that is susceptible to lymphatic dissemination.
Yuming Luo, Zhihua Li, Yao Kong, Wang He, Hanhao Zheng, M. An, Yan Lin, Dingwen Zhang, Jiabin Yang, Yue Zhao, Changhao Chen, Rufu Chen   +11 more
semanticscholar   +1 more source

M2b macrophages stimulate lymphangiogenesis to reduce myocardial fibrosis after myocardial ischaemia/reperfusion injury

Pharmaceutical Biology, 2022
Context Therapeutic lymphangiogenesis is a new treatment for cardiovascular diseases. Our previous study showed M2b macrophages can alleviate myocardial ischaemia/reperfusion injury (MI/RI).
Cuiping Wang, Y. Yue, Suiqing Huang, Keke Wang, X. Yang, Jiantao Chen, Jiaxing Huang, Zhong-dao Wu   +7 more
semanticscholar   +1 more source

CD137L-macrophage induce lymphatic endothelial cells autophagy to promote lymphangiogenesis in renal fibrosis

International Journal on Biological Sciences, 2022
Renal lymphangiogenesis is a new field of international nephrology in recent years and plays an important role in the progression of chronic renal disease.
Haotian Wei, Li Chen, Qing Li, Xinjun Liang, Kun Wang, Ying Zhang, Yueqiang Li, Yanyan Liu, Gang Xu   +8 more
semanticscholar   +1 more source

Signaling of Prostaglandin E Receptors, EP3 and EP4 Facilitates Wound Healing and Lymphangiogenesis with Enhanced Recruitment of M2 Macrophages in Mice. [PDF]

PLoS ONE, 2016
Lymphangiogenesis plays an important role in homeostasis, metabolism, and immunity, and also occurs during wound-healing. Here, we examined the roles of prostaglandin E2 (PGE2) receptor (EP) signaling in enhancement of lymphangiogenesis in wound healing ...
Kanako Hosono, Risa Isonaka, Tadashi Kawakami, Shuh Narumiya, Masataka Majima   +4 more
doaj   +1 more source

Lymphangiogenesis in renal fibrosis arises from macrophages via VEGF-C/VEGFR3-dependent autophagy and polarization

Cell Death and Disease, 2021
Inflammation plays a crucial role in the occurrence and development of renal fibrosis, which ultimately results in end-stage renal disease (ESRD). There is new focus on lymphangiogenesis in the field of inflammation.
Ying Zhang, Conghui Zhang, Lixi Li, Xinjun Liang, Peng Cheng, Qing Li, Xiaoyan Chang, Kun Wang, Shuai Huang, Yueqiang Li, Yanyan Liu, Gang Xu   +11 more
semanticscholar   +1 more source

Promoting inflammatory lymphangiogenesis by vascular endothelial growth factor-C (VEGF-C) aggravated intestinal inflammation in mice with experimental acute colitis [PDF]

Brazilian Journal of Medical and Biological Research, 2016
Angiogenesis and lymphangiogenesis are thought to play a role in the pathogenesis of inflammatory bowel diseases (IBD). However, it is not understood if inflammatory lymphangiogenesis is a pathological consequence or a productive attempt to resolve the ...
X.L. Wang, J. Zhao, L. Qin, M. Qiao
doaj   +3 more sources

Lymphangiogenesis is required for pancreatic islet inflammation and diabetes. [PDF]

PLoS ONE, 2011
Lymphangiogenesis is a common phenomenon observed during inflammation and engraftment of transplants, but its precise role in the immune response and underlying mechanisms of regulation remain poorly defined. Here we showed that in response to injury and
Na Yin, Nan Zhang, Girdhari Lal, Jiangnan Xu, Minhong Yan, Yaozhong Ding, Jonathan S Bromberg   +6 more
doaj   +1 more source

Tumor-associated macrophage, angiogenesis and lymphangiogenesis markers predict prognosis of non-small cell lung cancer patients

Journal of Translational Medicine, 2020
Background The tumor microenvironment (TME) is a critical player in tumor progression, metastasis and therapy outcomes. Tumor-associated macrophages (TAMs) are a well-recognized core element of the TME and generally characterized as M2-like macrophages ...
I. Hwang, J. Kim, Kris Ylaya, E. Chung, Haruhisa Kitano, Candice Perry, J. Hanaoka, J. Fukuoka, J. Chung, S. Hewitt   +9 more
semanticscholar   +1 more source

VEGF‐C/VEGFR‐3 axis protects against pressure‐overload induced cardiac dysfunction through regulation of lymphangiogenesis

Clinical and Translational Medicine, 2021
Prolonged pressure overload triggers cardiac hypertrophy and frequently leads to heart failure (HF). Vascular endothelial growth factor‐C (VEGF‐C) and its receptor VEGFR‐3 are components of the central pathway for lymphatic vessel growth (also known as ...
Qiu-Yue Lin, Yunlong Zhang, Jie Bai, Jin-qiu Liu, Hui-Hua Li   +4 more
semanticscholar   +1 more source