Results 31 to 40 of about 16,311 (176)

Lymphangiogenesis and Lesion Heterogeneity in Interstitial Lung Diseases

Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine, 2015
The lymphatic system has several physiological roles, including fluid homeostasis and the activation of adaptive immunity by fluid drainage and cell transport. Lymphangiogenesis occurs in adult tissues during various pathologic conditions.
Masahiro Yamashita
doaj   +1 more source

A zebrafish model of inflammatory lymphangiogenesis

Biology Open, 2015
Inflammatory bowel disease (IBD) is a disabling chronic inflammatory disease of the gastrointestinal tract. IBD patients have increased intestinal lymphatic vessel density and recent studies have shown that this may contribute to the resolution of IBD ...
Kazuhide S. Okuda, June Pauline Misa, Stefan H. Oehlers, Christopher J. Hall, Felix Ellett, Sultan Alasmari, Graham J. Lieschke, Kathryn E. Crosier, Philip S. Crosier, Jonathan W. Astin   +9 more
doaj   +1 more source

Integrins and Their Extracellular Matrix Ligands in Lymphangiogenesis and Lymph Node Metastasis

International Journal of Cell Biology, 2012
In the 1970s, the late Judah Folkman postulated that tumors grow proportionately to their blood supply and that tumor angiogenesis removed this limitation promoting growth and metastasis. Work over the past 40 years, varying from molecular examination to
Jie Chen, J. Steven Alexander, A. Wayne Orr   +2 more
doaj   +1 more source

Locoregional Immune Checkpoint Blockade and Remodeling of Lymph Nodes by Engineered Dendritic Cell‐Derived Exosomes for Suppressing Tumor Progression and Metastasis

Advanced Science, EarlyView.
The study develops engineered exosomes (EmDEX@GA) for locoregional immunomodulation of tumor‐draining lymph node (TDLN). EmDEX@GA can actively target to TDLN and remodel its immunosuppressive microenvironment through the synergistic effects of PD‐1/PD‐L1 blockade and STING pathway activation, subsequently enhance anti‐tumor immunity and suppress tumor ...
Yizhen Wang, Xiaomin Guo, Jingya Qin, Yifan Xue, Peng Zhang, Yadong Liu, Moyang Chen, Guanghao Zhu, Xinqiu Song, Lili Cheng, Bo Liu, Jie Liu, Jie Ren   +12 more
wiley   +1 more source

Integrating Aggregate Materials and Machine Learning Algorithms: Advancing Detection of Pathogen‐Derived Extracellular Vesicles

Aggregate, EarlyView.
Pathogen‐derived extracellular vesicle detection: theoretical insights and advanced methodologies: This review explores the theoretical foundations and practical applications of pEV detection, emphasizing the challenges and innovative strategies involving novel aggregate materials and machine learning for enhanced diagnostic accuracy.
Lihan Lai, Yun Su, Cong Hu, Zehong Peng, Wei Xue, Liang Dong, Tony Y. Hu   +6 more
wiley   +1 more source

ETV4 Mediated Tumor‐Associated Neutrophil Infiltration Facilitates Lymphangiogenesis and Lymphatic Metastasis of Bladder Cancer

Advanced Science, 2023
As a key step of tumor lymphatic metastasis, lymphangiogenesis is regulated by VEGFC‐VEGFR3 signaling pathway mediated by immune cells, mainly macrophages, in the tumor microenvironment.
Qiang Zhang, Sen Liu, Hongjin Wang, Kanghua Xiao, Junlin Lu, Siting Chen, Ming Huang, Ruihui Xie, Tianxin Lin, Xu Chen   +9 more
doaj   +1 more source

Establishment of a Prognostic Risk Score Model Based on Bioinformatics for Ferroptosis and Cuproptosis‐Related Genes in Gastric Cancer

Cancer Nexus, EarlyView.
ABSTRACT Background Gastric cancer (GC) stands out as one of the most prevalent forms of malignant tumors globally, characterized by a notably high mortality rate. In spite of progress in medical science and treatment alternatives, the survival rate over 5 years continues to stay under 40%.
Yang Shaokang, Yang Peng, Liu Zhicheng, Chen Yujia, He Qitong, Wang Daguang   +5 more
wiley   +1 more source

CRIP1 Reshapes the Gastric Cancer Microenvironment to Facilitate Development of Lymphatic Metastasis

Advanced Science, 2023
Lymphangiogenesis in tumors provides an auxiliary route for cancer cell invasion to drainage lymph nodes, facilitating the development of lymphatic metastasis (LM).
Zhonghua Wu, Bicheng Qu, Minxian Yuan, Jingjing Liu, Cen Zhou, Mingwei Sun, Zhexu Guo, Yaqing Zhang, Yongxi Song, Zhenning Wang   +9 more
doaj   +1 more source

Incidence and Prognostic Implications of Lymphovascular Invasion in Node‐Negative Pancreatic Neuroendocrine Tumors: Results From the US Neuroendocrine Study Group

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background Despite the well‐known prognostic role of lymph node metastasis (LNM) in pNETs, less is known about the importance of lymphovascular invasion (LVI) among patients with these tumors. Methods Patients undergoing pancreatectomy for pNET between 2002 and 2020 were identified in the US Neuroendocrine Tumor Study Group database.
Kota Sahara, Diamantis I. Tsilimigras, Yuki Homma, Jun Kawashima, Shishir K. Maithel, Flavio Rocha, Sharon Weber, Ryan Fields, Kamran Idrees, George A. Poultsides, Cliff Cho, Itaru Endo, Timothy M. Pawlik   +12 more
wiley   +1 more source

Targeting tubulointerstitial remodeling in proteinuric nephropathy in rats

Disease Models & Mechanisms, 2015
Proteinuria is an important cause of tubulointerstitial damage. Anti-proteinuric interventions are not always successful, and residual proteinuria often leads to renal failure.
Saleh Yazdani, Ryanne S. Hijmans, Fariba Poosti, Wendy Dam, Gerjan Navis, Harry van Goor, Jacob van den Born   +6 more
doaj   +1 more source