Results 31 to 40 of about 43,762 (300)

Lymphangiogenesis [PDF]

Computational and Mathematical Methods in Medicine, 2003
While much effort is given to the modelling of tumour angiogenesis, little attention is paid to lymphangiogenesis and its potential role in tumour progression and metastasis. This is due at least in part to the controversy that surrounds tumour lymphangiogenesis—opinion is divided as to whether tumours actively promote the development of lymph channels
Catherine R. Tait, Pamela F. Jones
openaire   +1 more source

Signaling of Prostaglandin E Receptors, EP3 and EP4 Facilitates Wound Healing and Lymphangiogenesis with Enhanced Recruitment of M2 Macrophages in Mice. [PDF]

PLoS ONE, 2016
Lymphangiogenesis plays an important role in homeostasis, metabolism, and immunity, and also occurs during wound-healing. Here, we examined the roles of prostaglandin E2 (PGE2) receptor (EP) signaling in enhancement of lymphangiogenesis in wound healing ...
Kanako Hosono, Risa Isonaka, Tadashi Kawakami, Shuh Narumiya, Masataka Majima   +4 more
doaj   +1 more source

Rescue of Angiopoietin-2 Inhibits Proliferation of Lymphatic Malformation Endothelial Cells. [PDF]

FASEB J
Mechanistic summary of how autocrine ANG2 suppressed LMEC proliferation. Somatic activating SNVs in PIK3CA result in increased PI3K/Akt signaling, Akt‐mediated downregulation of ANG2, and LMEC hyperproliferation. Restoration of autocrine ANG2 in LMECs through overexpression suppressed LMEC proliferation in vitro and lymphangiogenesis in vivo and was ...
Sun RW, Zhang H, Mehdi SJ, Bowen JK, Burnett AK, Richter GT, Washam CL, Byrum SD, Wu JK, Shawber CJ, Strub GM.   +10 more
europepmc   +2 more sources

PEDF inhibits lymphatic metastasis of nasopharyngeal carcinoma as a new lymphangiogenesis inhibitor

Cell Death and Disease, 2021
Nasopharyngeal carcinoma (NPC) is one of the most malignant tumors in southern China and Asia, and lymph node metastasis is an important cause for treatment failure.
Chuanghua Luo, Haofan Yin, Tianxiao Gao, Caiqi Ma, Junxi Liu, Ting Zhang, Zumin Xu, Xi Wang, Danrui Zhang, Weiwei Qi, Zhonghan Yang, Guoquan Gao, Xia Yang, Ti Zhou   +13 more
doaj   +1 more source

Lymphangiogenesis in renal fibrosis arises from macrophages via VEGF-C/VEGFR3-dependent autophagy and polarization

Cell Death and Disease, 2021
Inflammation plays a crucial role in the occurrence and development of renal fibrosis, which ultimately results in end-stage renal disease (ESRD). There is new focus on lymphangiogenesis in the field of inflammation.
Ying Zhang, Conghui Zhang, Lixi Li, Xinjun Liang, Peng Cheng, Qing Li, Xiaoyan Chang, Kun Wang, Shuai Huang, Yueqiang Li, Yanyan Liu, Gang Xu   +11 more
semanticscholar   +1 more source

Role of Extracellular Vesicles on Cancer Lymphangiogenesis and Lymph Node Metastasis

Frontiers in Oncology, 2021
Lymph node metastasis (LNM) of tumors is an established indicator of poor prognosis in patients. Tumor-associated lymphangiogenesis is a key step in LNM and has gained much attention. However, currently, there is no anti-tumor lymphangiogenesis drug used
Linlin Wang, Ling Li, Guiquan Zhu
doaj   +1 more source

Promoting Lymphangiogenesis and Lymphatic Growth and Remodeling to Treat Cardiovascular and Metabolic Diseases.

Arteriosclerosis, Thrombosis and Vascular Biology, 2022
Lymphatic vessels are low-pressure, blind-ended tubular structures that play a crucial role in the maintenance of tissue fluid homeostasis, immune cell trafficking, and dietary lipid uptake and transport.
Xiaolei Liu, Kui Cui, Haolan Wu, Kathryn Li, Qianman Peng, Donghai Wang, Douglas B. Cowan, J. B. Dixon, R. Sathish Srinivasan, D. Bielenberg, Kaifu Chen, Da-Zhi Wang, Yabing Chen, Hong Chen   +13 more
semanticscholar   +1 more source

Promoting inflammatory lymphangiogenesis by vascular endothelial growth factor-C (VEGF-C) aggravated intestinal inflammation in mice with experimental acute colitis [PDF]

Brazilian Journal of Medical and Biological Research, 2016
Angiogenesis and lymphangiogenesis are thought to play a role in the pathogenesis of inflammatory bowel diseases (IBD). However, it is not understood if inflammatory lymphangiogenesis is a pathological consequence or a productive attempt to resolve the ...
X.L. Wang, J. Zhao, L. Qin, M. Qiao
doaj   +3 more sources

Tumor-associated macrophage, angiogenesis and lymphangiogenesis markers predict prognosis of non-small cell lung cancer patients

Journal of Translational Medicine, 2020
Background The tumor microenvironment (TME) is a critical player in tumor progression, metastasis and therapy outcomes. Tumor-associated macrophages (TAMs) are a well-recognized core element of the TME and generally characterized as M2-like macrophages ...
I. Hwang, J. Kim, Kris Ylaya, E. Chung, Haruhisa Kitano, Candice Perry, J. Hanaoka, J. Fukuoka, J. Chung, S. Hewitt   +9 more
semanticscholar   +1 more source

VEGF‐C/VEGFR‐3 axis protects against pressure‐overload induced cardiac dysfunction through regulation of lymphangiogenesis

Clinical and Translational Medicine, 2021
Prolonged pressure overload triggers cardiac hypertrophy and frequently leads to heart failure (HF). Vascular endothelial growth factor‐C (VEGF‐C) and its receptor VEGFR‐3 are components of the central pathway for lymphatic vessel growth (also known as ...
Qiu-Yue Lin, Yunlong Zhang, Jie Bai, Jin-qiu Liu, Hui-Hua Li   +4 more
semanticscholar   +1 more source