Results 31 to 40 of about 27,751 (253)

Myeloid Cells and Lymphangiogenesis [PDF]

Cold Spring Harbor Perspectives in Medicine, 2012
The lymphatic vascular system and the hematopoietic system are intimately connected in ontogeny and in physiology. During embryonic development, mammalian species derive a first lymphatic vascular plexus from the previously formed anterior cardinal vein, whereas birds and amphibians have a lymphatic vascular system of dual origin, composed of lymphatic
Zumsteg, Adrian, Christofori, Gerhard
openaire   +4 more sources

Identification of Gene Expression Differences between Lymphangiogenic and Non-Lymphangiogenic Non-Small Cell Lung Cancer Cell Lines. [PDF]

PLoS ONE, 2016
It is well established that lung tumors induce the formation of lymphatic vessels. However, the molecular mechanisms controlling tumor lymphangiogenesis in lung cancer have not been fully delineated. In the present study, we identify a panel of non-small
Erin Regan, Robert C Sibley, Bercin Kutluk Cenik, Asitha Silva, Luc Girard, John D Minna, Michael T Dellinger   +6 more
doaj   +1 more source

Current Status of Lymphangiogenesis: Molecular Mechanism, Immune Tolerance, and Application Prospect

Cancers, 2023
Simple Summary Lymphatic vessels are low-pressure, blind-ended tubular structures essential in maintaining tissue fluid homeostasis, immune cell transport, and lipid transport. More and more evidence showed that lymphangiogenesis might be closely related
Hongyang Deng, Jiaxing Zhang, Fahong Wu, Feng-xian Wei, Wei Han, Xiao-dong Xu, Youcheng Zhang   +6 more
semanticscholar   +1 more source

Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism.

Nature Cancer, 2021
Secreted extracellular vesicles (EVs) influence the tumor microenvironment and promote distal metastasis. Here we analyzed the involvement of melanoma-secreted EVs in lymph node pre-metastatic niche formation in murine models.
S. García-Silva, A. Benito‐Martin, Laura Nogués, Alberto Hernández-Barranco, Marina S. Mazariegos, Vanesa Santos, M. Hergueta-Redondo, P. Ximénez-Embún, Raghu P. Kataru, Ana Amor López, C. Merino, S. Sánchez-Redondo, Osvaldo Graña-Castro, Irina R Matei, J. A. Nicolás-Ávila, R. Torres-Ruiz, S. Rodríguez-Perales, Lola Martínez, Manuel Pérez-Martínez, Gadea Mata, A. Szumera-Ciećkiewicz, I. Kalinowska, A. Saltari, J. M. Martinez-Gomez, S. Hogan, H. Saragovi, S. Ortega, C. García-Martín, J. Boskovic, M. Levesque, P. Rutkowski, A. Hidalgo, J. Muñoz, D. Megías, B. Mehrara, D. Lyden, H. Peinado   +36 more
semanticscholar   +1 more source

Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression

Journal of Clinical Investigation, 2022
Vascular endothelial growth factor C (VEGF-C) induces lymphangiogenesis via VEGF receptor 3 (VEGFR3), which is encoded by the most frequently mutated gene in human primary lymphedema. Angiopoietins (Angs) and their Tie receptors regulate lymphatic vessel
E. A. Korhonen, Aino Murtomäki, S. K. Jha, A. Anisimov, A. Pink, Yan Zhang, Simon Stritt, Inam Liaqat, L. Stanczuk, Laura Alderfer, Zhiliang Sun, Emmi Kapiainen, Abhishek Singh, Ibrahim Sultan, Anni Lantta, V. Leppänen, L. Eklund, Yulong He, H. Augustin, Kari Vaahtomeri, P. Saharinen, Taija Mäkinen, K. Alitalo   +22 more
semanticscholar   +1 more source

Lymphangiogenesis and tumor metastasis [PDF]

Thrombosis and Haemostasis, 2003
SummaryIn several human cancers, increased expression in primary tumors of vascular endothelial growth factor-C (VEGF-C) is correlated with regional lymph node metastasis. Studies using transgenic mice overexpressing VEGF-C, or xenotransplantation of VEGF-C-expressing tumor cells into immunodeficient mice, have demonstrated a role for VEGF-C in tumor ...
Michael S. Pepper, Riccardo E. Nisato, Jean-Christophe Tille   +2 more
openaire   +6 more sources

Does plasminogen activator inhibitor-1 drive lymphangiogenesis? [PDF]

PLoS ONE, 2010
The purpose of this study is to explore the function of plasminogen activator inhibitor-1 (PAI-1) during pathological lymphangiogenesis. PAI-1, the main physiological inhibitor of plasminogen activators is involved in pathological angiogenesis at least ...
Françoise Bruyère, Laurence Melen-Lamalle, Silvia Blacher, Benoît Detry, Anne Masset, Julie Lecomte, Vincent Lambert, Catherine Maillard, Gunilla Høyer-Hansen, Leif R Lund, Jean-Michel Foidart, Agnès Noël   +11 more
doaj   +1 more source

Integrins in angiogenesis and lymphangiogenesis [PDF]

Nature Reviews Cancer, 2008
Blood vessels promote tumour growth, and both blood and lymphatic vessels facilitate tumour metastasis by serving as conduits for the transport of tumour cells to new sites. Angiogenesis and lymphangiogenesis are regulated by integrins, which are members of a family of cell surface receptors whose ligands are extracellular matrix proteins and ...
Christie J. Avraamides, Barbara Garmy‐Susini, Judith A. Varner   +2 more
openalex   +5 more sources

Lymphangiogenesis and cancer metastasis [PDF]

Journal of Cellular and Molecular Medicine, 2009
Abstract Anatomy and function of the lymphatic system Tumour‐induced lymphangiogenesis promotes metastasis Tumour‐induced lymph node lymphangiogenesis precedes cancer metastasis to lymph nodes Tumour cell invasion into lymphatic vessels Peri‐ and intra‐tumoral lymphangiogenesis Lymphatic vessel markers and lymphangiogenic growth factors Preventive and ...
Viviane Mumprecht, Michael Detmar
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circNFIB1 inhibits lymphangiogenesis and lymphatic metastasis via the miR-486-5p/PIK3R1/VEGF-C axis in pancreatic cancer

Molecular Cancer, 2020
Background Patients with lymph node (LN)-positive pancreatic ductal adenocarcinoma (PDAC) have extremely poor survival rates. Circular RNAs (circRNAs), a newly discovered type of endogenous noncoding RNAs, have been proposed to mediate the progression of
Yao Kong, Yuting Li, Yuming Luo, Jiang Zhu, Hanhao Zheng, Bowen Gao, Xiao-Zhong Guo, Zhihua Li, Rufu Chen, Changhao Chen   +9 more
semanticscholar   +1 more source