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Signaling in Lymphocyte Activation [PDF]

Cold Spring Harbor Perspectives in Biology, 2015
The fate of T and B lymphocytes, the key cells that direct the adaptive immune response, is regulated by a diverse network of signal transduction pathways. The T- and B-cell antigen receptors are coupled to intracellular tyrosine kinases and adaptor molecules to control the metabolism of inositol phospholipids and calcium release.
D. Cantrell
openaire   +4 more sources

Continuous Modeling of T CD4 Lymphocyte Activation and Function [PDF]

Frontiers in Immunology, 2021
T CD4+ cells are central to the adaptive immune response against pathogens. Their activation is induced by the engagement of the T-cell receptor by antigens, and of co-stimulatory receptors by molecules also expressed on antigen presenting cells. Then, a
David Martínez-Méndez, Luis Mendoza, Luis Mendoza, Carlos Villarreal, Carlos Villarreal, Leonor Huerta   +5 more
doaj   +2 more sources

Biophysical aspects of T lymphocyte activation at the immune synapse

Frontiers in Immunology, 2016
T lymphocyte activation is a pivotal step of the adaptive immune response. It requires the recognition by T-cell receptors (TCR) of peptides presented in the context of major histocompatibility complex molecules (pMHC) present at the surface of antigen ...
Claire eHivroz
doaj   +2 more sources

The regulation of lymphocyte activation and proliferation.

Current Opinion in Immunology, 2018
S. Heinzel, Julia M. Marchingo, M. Horton, P. Hodgkin   +3 more
semanticscholar   +3 more sources

Lymphocyte Activation Process [PDF]

Definitions, 2020
openaire   +2 more sources

Comprehensive analysis of signaling lymphocyte activation molecule family as a prognostic biomarker and correlation with immune infiltration in clear cell renal cell carcinoma. [PDF]

Oncol Lett
Song N, Wang Z, Shi P, Cui K, Fan Y, Zeng L, Di W, Li J, Su W, Wang H.   +9 more
europepmc   +3 more sources

Mucosal Genomics Implicate Lymphocyte Activation and Lipid Metabolism in Refractory Environmental Enteric Dysfunction

Gastroenterology, 2021
Background & Aims Environmental enteric dysfunction (EED) limits the Sustainable Development Goals of improved childhood growth and survival. We applied mucosal genomics to advance our understanding of EED.
Y. Haberman, N. Iqbal, S. Ghandikota, Indika V. Mallawaarachchi, T. Braun, P. Dexheimer, N. Rahman, R. Hadar, K. Sadiq, Z. Ahmad, Romana Idress, J. Iqbal, Sheraz Ahmed, A. Hotwani, F. Umrani, L. Ehsan, Gregory L. Medlock, S. Syed, C. Moskaluk, Jennie Z. Ma, A. Jegga, S. Moore, S. Ali, L. Denson   +23 more
semanticscholar   +1 more source

Inherited immunodeficiencies associated with proximal and distal defects in T cell receptor signaling and co-signaling

Biomedical Journal, 2022
T lymphocytes are central cells of adaptive immunity. Activation of T lymphocytes by the antigen receptor of T cells (TCR) and co-stimulatory molecules involve specific signaling components and cascades.
Sylvain Latour
doaj   +1 more source

Activation of lymphocytes [PDF]

Journal of Clinical Pathology, 1967
The technique involved in studying the activation of lymphocytes in the resting form, and their recognition as dividing and functional cells was studied, using phase contrast and agar as well as fluid culture. Standardization of technical methods was found to be essential, and the effect of variables was studied.
R J, Pulvertaft, I, Pulvertaft
openaire   +2 more sources

FcγRI FG-loop functions as a pH sensitive switch for IgG binding and release

Frontiers in Immunology, 2023
Understanding the molecular mechanism underlying the hierarchic binding between FcγRs and IgG antibodies is critical for therapeutic antibody engineering and FcγR functions.
Jinghua Lu, Matthew Spencer, Zhongcheng Zou, Maria Traver, Joseph Brzostowski, Peter D. Sun   +5 more
doaj   +1 more source