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Continuous Modeling of T CD4 Lymphocyte Activation and Function [PDF]
Frontiers in Immunology, 2021 T CD4+ cells are central to the adaptive immune response against pathogens. Their activation is induced by the engagement of the T-cell receptor by antigens, and of co-stimulatory receptors by molecules also expressed on antigen presenting cells. Then, a
David Martínez-Méndez +5 more
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Mechanosensing in T Lymphocyte Activation [PDF]
Biophysical Journal, 2012 Mechanical forces play an increasingly recognized role in modulating cell function. This report demonstrates mechanosensing by T cells, using polyacrylamide gels presenting ligands to CD3 and CD28. Naive CD4 T cells exhibited stronger activation, as measured by attachment and secretion of IL-2, with increasing substrate elastic modulus over the range ...
Judokusumo, E +4 more
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Effect of corticosteroids on lymphocyte activation [PDF]
Blood, 1977 Human peripheral blood lymphocytes were stimulated by concanavalin A, sodium periodate, and neuraminidase plus galactose oxidase. Response to mitogens was measured by the amount of tritiated thymidine incorporated as well as the percent of “giant sheep red blood cell rosettes” generated.
DT Yu
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Prognostic impact of a lymphocyte activation-associated gene signature in GBM based on transcriptome analysis [PDF]
PeerJ, 2021 Background Glioblastoma multiforme (GBM) is a highly, malignant tumor of the primary central nervous system. Patients diagnosed with this type of tumor have a poor prognosis.
Yujia Lan +7 more
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Activation of lymphocytes [PDF]
Journal of Clinical Pathology, 1967 The technique involved in studying the activation of lymphocytes in the resting form, and their recognition as dividing and functional cells was studied, using phase contrast and agar as well as fluid culture. Standardization of technical methods was found to be essential, and the effect of variables was studied.
R. J. V. Pulvertaft, Isobel Pulvertaft
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CTP Synthase 1 Is a Novel Therapeutic Target in Lymphoma
HemaSphere, 2023 Lymphoma is the most common hematological malignancy and is among the 10 most prevalent cancers worldwide. Although survival has been improved by modern immunochemotherapeutic regimens, there remains a significant need for novel targeted agents to treat ...
Hélène Asnagli +13 more
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FcγRI FG-loop functions as a pH sensitive switch for IgG binding and release
Frontiers in Immunology, 2023 Understanding the molecular mechanism underlying the hierarchic binding between FcγRs and IgG antibodies is critical for therapeutic antibody engineering and FcγR functions.
Jinghua Lu +5 more
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The Activation of Lymphocytes Is in Their CARMA [PDF]
Immunity, 2003 Lymphocyte activation via antigen receptors initiates adaptive immune responses. Two papers in this issue of Immunity demonstrate that CARMA-1, a CARD carrying member of the MAGUK family proteins, is essential for lymphocyte activation. CARMA-1 functions by coupling antigen receptor signals to NF-kappaB induction and JNK activation.
Abul K. Abbas, Ranjan Sen
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Frontiers in Immunology, 2023 IntroductionAlthough children seem to be less susceptible to COVID-19, some of them develop a rare but serious hyperinflammatory condition called multisystem inflammatory syndrome in children (MIS-C).
Andreja Nataša Kopitar +11 more
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Reversal of splicing infidelity is a pre-activation step in B cell differentiation
Frontiers in Immunology, 2022 IntroductionB cell activation and differentiation is central to the adaptive immune response. Changes in exon usage can have major impacts on cellular signaling and differentiation but have not been systematically explored in differentiating B cells ...
Tina M. O’Grady +5 more
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