Results 1 to 10 of about 133,131 (124)
Effect of corticosteroids on lymphocyte activation [PDF]
Blood, 1977 Human peripheral blood lymphocytes were stimulated by concanavalin A, sodium periodate, and neuraminidase plus galactose oxidase. Response to mitogens was measured by the amount of tritiated thymidine incorporated as well as the percent of “giant sheep red blood cell rosettes” generated.
DT Yu
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Activation of lymphocytes [PDF]
Journal of Clinical Pathology, 1967 The technique involved in studying the activation of lymphocytes in the resting form, and their recognition as dividing and functional cells was studied, using phase contrast and agar as well as fluid culture. Standardization of technical methods was found to be essential, and the effect of variables was studied.
R. J. V. Pulvertaft, Isobel Pulvertaft
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Mechanosensing in T Lymphocyte Activation [PDF]
Biophysical Journal, 2012 Mechanical forces play an increasingly recognized role in modulating cell function. This report demonstrates mechanosensing by T cells, using polyacrylamide gels presenting ligands to CD3 and CD28. Naive CD4 T cells exhibited stronger activation, as measured by attachment and secretion of IL-2, with increasing substrate elastic modulus over the range ...
Judokusumo, E +4 more
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The Activation of Lymphocytes Is in Their CARMA [PDF]
Immunity, 2003 Lymphocyte activation via antigen receptors initiates adaptive immune responses. Two papers in this issue of Immunity demonstrate that CARMA-1, a CARD carrying member of the MAGUK family proteins, is essential for lymphocyte activation. CARMA-1 functions by coupling antigen receptor signals to NF-kappaB induction and JNK activation.
Abul K. Abbas, Ranjan Sen
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Signaling in Lymphocyte Activation [PDF]
Cold Spring Harbor Perspectives in Biology, 2015 The fate of T and B lymphocytes, the key cells that direct the adaptive immune response, is regulated by a diverse network of signal transduction pathways. The T- and B-cell antigen receptors are coupled to intracellular tyrosine kinases and adaptor molecules to control the metabolism of inositol phospholipids and calcium release.
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Activated T lymphocytes in uveitis. [PDF]
British Journal of Ophthalmology, 1988 Two colour flow cytometry techniques were used to assess the activation stages of peripheral and intraocular T lymphocytes in uveitis. Increased numbers of T lymphocytes bearing the interleukin-2 (IL-2) receptors were found in intraocular fluids or peripheral blood or both of 35/51 patients with uveitis.
J. Deschênes, S. Kaleta, Devron H. Char
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Isolation and Activation of Murine Lymphocytes [PDF]
Journal of Visualized Experiments, 2016 B and T cells, with their extremely diverse antigen-receptor repertoires, have the ability to mount specific immune responses against almost any invading pathogen1,2. Understandably, such intricate abilities are controlled by a large number of molecules involved in various cellular processes to ensure timely and spatially regulated immune responses3 ...
Lim, Jun Feng, Berger, Heidi, Su, I-hsin
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Activation and inhibition of lymphocytes by costimulation [PDF]
Journal of Clinical Investigation, 2002 Mounting an appropriate immune response depends on the careful regulation of lymphocyte activation. To this end, lymphocytes require two independent signals to become fully activated. The first, an antigen-specific signal is sent via the unique antigen receptor: T cell receptor (TCR) on T cells or surface Ig on B cells.
Kenneth A. Frauwirth, Craig B. Thompson
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Genome-wide discovery of modulators of transcriptional interactions in human B lymphocytes [PDF]
RECOMB'06 Proceedings, LNCS 3909, Springer, 2006, 2005 Transcriptional interactions in a cell are modulated by a variety of mechanisms that prevent their representation as pure pairwise interactions between a transcription factor and its target(s). These include, among others, transcription factor activation by phosphorylation and acetylation, formation of active complexes with one or more co-factors, and ...
arxiv +1 more source
Molecular tug of war reveals adaptive potential of an immune cell repertoire [PDF]
arXiv, 2022 The adaptive immune system constantly remodels its lymphocyte repertoire for better protection against future pathogens. Its ability to improve antigen recognition on the fly relies on somatic mutation and selective expansion of B lymphocytes expressing high-affinity antigen receptors.
arxiv