Results 31 to 40 of about 4,142,040 (366)
Lymphocyte Activation Gene 3 (LAG-3) Modulates the Ability of CD4 T-cells to Be Suppressed In Vivo
PLoS ONE, 2014 Lymphocyte Activation Gene – 3 (LAG-3) is an immune checkpoint molecule that regulates both T-cell activation and homeostasis. However, the molecular mechanisms underlying LAG-3’s function are generally unknown.
N. Durham +6 more
semanticscholar +1 more source
Single Cell Transcriptomics Implicate Novel Monocyte and T Cell Immune Dysregulation in Sarcoidosis
Frontiers in Immunology, 2020 Sarcoidosis is a systemic inflammatory disease characterized by infiltration of immune cells into granulomas. Previous gene expression studies using heterogeneous cell mixtures lack insight into cell-type-specific immune dysregulation.
Lori Garman +10 more
doaj +1 more source
Activation and inhibition of lymphocytes by costimulation [PDF]
Journal of Clinical Investigation, 2002 Mounting an appropriate immune response depends on the careful regulation of lymphocyte activation. To this end, lymphocytes require two independent signals to become fully activated. The first, an antigen-specific signal is sent via the unique antigen receptor: T cell receptor (TCR) on T cells or surface Ig on B cells.
Kenneth A. Frauwirth, Craig B. Thompson
openaire +3 more sources
The M1 and M2 paradigm of macrophage activation: time for reassessment
F1000Prime Reports, 2014 Macrophages are endowed with a variety of receptors for lineage-determining growth factors, T helper (Th) cell cytokines, and B cell, host, and microbial products.
F. Martínez, S. Gordon
semanticscholar +1 more source
Genome-wide discovery of modulators of transcriptional interactions in human B lymphocytes [PDF]
RECOMB'06 Proceedings, LNCS 3909, Springer, 2006, 2005 Transcriptional interactions in a cell are modulated by a variety of mechanisms that prevent their representation as pure pairwise interactions between a transcription factor and its target(s). These include, among others, transcription factor activation by phosphorylation and acetylation, formation of active complexes with one or more co-factors, and ...
arxiv +1 more source
Serum microRNAs as Biomarkers of Human Lymphocyte Activation in Health and Disease
Frontiers in Immunology, 2014 Induction of the adaptive immune system is evaluated mostly by assessment of serum antibody titers and T lymphocyte responses in peripheral blood, although T and B cell activation occurs in lymphoid tissues.
P. de Candia +3 more
semanticscholar +1 more source
Frontiers in Immunology, 2018 Few studies investigate the major protein antigens targeted by the antibody diversity of infected mice with Trypanosoma cruzi. To detect global IgG antibody specificities, sera from infected mice were immunoblotted against whole T. cruzi extracts.
Fabricio Montalvão +15 more
doaj +1 more source
Molecular tug of war reveals adaptive potential of an immune cell repertoire [PDF]
arXiv, 2022 The adaptive immune system constantly remodels its lymphocyte repertoire for better protection against future pathogens. Its ability to improve antigen recognition on the fly relies on somatic mutation and selective expansion of B lymphocytes expressing high-affinity antigen receptors.
arxiv
Reaction-diffusion systems derived from kinetic theory for Multiple Sclerosis [PDF]
, 2023 We present a mathematical study for the development of Multiple Sclerosis in which a spatio-temporal kinetic { theory} model describes, at the mesoscopic level, the dynamics of a high number of interacting agents. We consider both interactions among different populations of human cells and the motion of immune cells, stimulated by cytokines.
arxiv +1 more source
Biomédica: revista del Instituto Nacional de Salud, 2008 Introducción. La presencia de infecciones por patógenos oportunistas en pacientes con síndrome de inmunodeficiencia adquirida representa un coestímulo para acelerar la progresión de la infección por el VIH-1.
Carlos Julio Montoya +4 more
doaj +1 more source