Results 31 to 40 of about 510,498 (357)
Бюллетень сибирской медицины, 2019 Background. The reason why HIV-infected patients receiving highly active antiretroviral therapy (HAART) suffer from the increased immune activation remains elusive.
V. A. Chereshnev +4 more
doaj +1 more source
Physiological Reports, 2021 Regular exercise is associated with changes in peripheral blood mononuclear cell (PBMC) proportions that have enhanced effector functions in young and old adults; however, the effects of acute exercise on PBMC nutrient sensors and metabolic function in ...
Bailey Theall +6 more
doaj +1 more source
Isolation and Activation of Murine Lymphocytes [PDF]
Journal of Visualized Experiments, 2016 B and T cells, with their extremely diverse antigen-receptor repertoires, have the ability to mount specific immune responses against almost any invading pathogen1,2. Understandably, such intricate abilities are controlled by a large number of molecules involved in various cellular processes to ensure timely and spatially regulated immune responses3 ...
Lim, Jun Feng, Berger, Heidi, Su, I-hsin
openaire +4 more sources
T-cell modulation for the treatment of chronic plaque psoriasis with efalizumab (Raptiva (TM)): Mechanisms of action [PDF]
, 2004 Psoriasis is a chronic, incurable, auto-immune disorder with cutaneous manifestations. New evidence on the central role of the immune system in the pathogenesis of psoriasis increasingly provides insight into pathogenic steps that can be modulated to ...
Caro, I. +7 more
core +1 more source
Combinatorial functions of two chimeric antibodies directed to human CD4 and one directed to the a-chain of the human interleukin-2 receptor [PDF]
, 1992 The general feasibility of chimerization of monoclonal antibodies (mAbs) has already been shown for a large number of them. In order to evaluate in vitro parameters relevant to immunosuppressive therapy, we have chimerized and synthesized two anti-CD4 ...
Flieger, Dimitri +10 more
core +1 more source
Single Cell Transcriptomics Implicate Novel Monocyte and T Cell Immune Dysregulation in Sarcoidosis
Frontiers in Immunology, 2020 Sarcoidosis is a systemic inflammatory disease characterized by infiltration of immune cells into granulomas. Previous gene expression studies using heterogeneous cell mixtures lack insight into cell-type-specific immune dysregulation.
Lori Garman +10 more
doaj +1 more source
Activation and inhibition of lymphocytes by costimulation [PDF]
Journal of Clinical Investigation, 2002 Mounting an appropriate immune response depends on the careful regulation of lymphocyte activation. To this end, lymphocytes require two independent signals to become fully activated. The first, an antigen-specific signal is sent via the unique antigen receptor: T cell receptor (TCR) on T cells or surface Ig on B cells.
Kenneth A. Frauwirth, Craig B. Thompson
openaire +3 more sources
Journal of Lipid Research, 2010 n-3 polyunsaturated fatty acids (PUFAs) modify T-cell activation, in part by remodeling lipid composition; however, the relationship between n-3 PUFA and B-cell activation is unknown.
Benjamin Drew Rockett +4 more
doaj +1 more source
Impact of aging : sporadic, and genetic risk factors on vulnerability to apoptosis in Alzheimer's disease [PDF]
, 2003 The identification of specific genetic (presenilin-1 [PS1] and amyloid precursor protein [APP] mutations) and environmental factors responsible for Alzheimer's disease (AD) has revealed evidence for a shared pathway of neuronal death.
Czech, Christian +11 more
core +1 more source
Frontiers in Immunology, 2018 Few studies investigate the major protein antigens targeted by the antibody diversity of infected mice with Trypanosoma cruzi. To detect global IgG antibody specificities, sera from infected mice were immunoblotted against whole T. cruzi extracts.
Fabricio Montalvão +15 more
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