Results 41 to 50 of about 4,108,240 (367)

Antibody Repertoires Identify β-Tubulin as a Host Protective Parasite Antigen in Mice Infected With Trypanosoma cruzi

Frontiers in Immunology, 2018
Few studies investigate the major protein antigens targeted by the antibody diversity of infected mice with Trypanosoma cruzi. To detect global IgG antibody specificities, sera from infected mice were immunoblotted against whole T. cruzi extracts.
Fabricio Montalvão, Fabricio Montalvão, Danielle Oliveira Nascimento, Marise P. Nunes, Carolina M. Koeller, Alexandre Morrot, Alexandre Morrot, Leticia Miranda S. Lery, Paulo M. Bisch, Santuza M. R. Teixeira, Rita Vasconcellos, Leonardo Freire-de-Lima, Marcela F. Lopes, Norton Heise, George A. DosReis, Célio Geraldo Freire-de-Lima   +15 more
doaj   +1 more source

The clinical spectrum of SMA‐PME and in vitro normalization of its cellular ceramide profile

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1941-1952, December 2022., 2022
Abstract Objective The objectives of this study were to define the clinical and biochemical spectrum of spinal muscular atrophy with progressive myoclonic epilepsy (SMA‐PME) and to determine if aberrant cellular ceramide accumulation could be normalized by enzyme replacement.
Michelle M. Lee, Graeme S. V. McDowell, Darryl C. De Vivo, Daniel Friedman, Samuel F. Berkovic, Maria Spanou, Argirios Dinopoulos, Katheryn Grand, Pedro A. Sanchez‐Lara, Michelle Allen‐Sharpley, Jodi Warman‐Chardon, Alexander Solyom, Thierry Levade, Edward H. Schuchman, Steffany A. L. Bennett, David A. Dyment, Toni S. Pearson   +16 more
wiley   +1 more source

Serum microRNAs as Biomarkers of Human Lymphocyte Activation in Health and Disease

Frontiers in Immunology, 2014
Induction of the adaptive immune system is evaluated mostly by assessment of serum antibody titers and T lymphocyte responses in peripheral blood, although T and B cell activation occurs in lymphoid tissues.
P. de Candia, A. Torri, M. Pagani, S. Abrignani   +3 more
semanticscholar   +1 more source

The WT hemochromatosis protein HFE inhibits CD8+ T‐lymphocyte activation

European Journal of Immunology, 2014
MHC class I (MHC I) antigen presentation is a ubiquitous process by which cells present endogenous proteins to CD8+ T lymphocytes during immune surveillance and response.
A. Reuben, Mikaël Phénix, Manuela M. Santos, R. Lapointe   +3 more
semanticscholar   +1 more source

Reaction-diffusion systems derived from kinetic theory for Multiple Sclerosis [PDF]

, 2023
We present a mathematical study for the development of Multiple Sclerosis in which a spatio-temporal kinetic { theory} model describes, at the mesoscopic level, the dynamics of a high number of interacting agents. We consider both interactions among different populations of human cells and the motion of immune cells, stimulated by cytokines.
arxiv   +1 more source

Thymic selection of T-cell receptors as an extreme value problem [PDF]

Phys. Rev. Lett. 103 (2009) 068103, 2009
T lymphocytes (T cells) orchestrate adaptive immune responses upon activation. T cell activation requires sufficiently strong binding of T cell receptors (TCRs) on their surface to short peptides (p) derived from foreign proteins, which are bound to major histocompatibility (MHC) gene products (displayed on antigen presenting cells). A diverse and self-
arxiv   +1 more source

The impact of adiposity on adipose tissue-resident lymphocyte activation in humans

International Journal of Obesity, 2014
Background/objectives:The presence of T lymphocytes in human adipose tissue has only recently been demonstrated and relatively little is known of their potential relevance in the development of obesity-related diseases.
Rebecca L Travers, A. C. Motta, J. Betts, A. Bouloumié, Dylan Thompson   +4 more
semanticscholar   +1 more source

Novel disulfide bond-mediated dimerization of the CARD domain was revealed by the crystal structure of CARMA1 CARD. [PDF]

PLoS ONE, 2013
CARMA1, BCL10 and MALT1 form a large molecular complex known as the CARMA1 signalosome during lymphocyte activation. Lymphocyte activation via the CARMA1 signalosome is critical to immune response and linked to many immune diseases. Despite the important
Tae-ho Jang, Jin Hee Park, Hyun Ho Park
doaj   +1 more source

Parallel processing in immune networks [PDF]

, 2012
In this work we adopt a statistical mechanics approach to investigate basic, systemic features exhibited by adaptive immune systems. The lymphocyte network made by B-cells and T-cells is modeled by a bipartite spin-glass, where, following biological prescriptions, links connecting B-cells and T-cells are sparse. Interestingly, the dilution performed on
arxiv   +1 more source

Autophosphorylation and the dynamics of the activation of Lck [PDF]

arXiv, 2021
Lck (lymphocyte-specific protein tyrosine kinase) is an enzyme which plays a number of important roles in the function of immune cells. It belongs to the Src family of kinases which are known to undergo autophosphorylation. It turns out that this leads to a remarkable variety of dynamical behaviour which can occur during their activation. We prove that
arxiv