Results 41 to 50 of about 4,241,016 (384)

Lymphocyte activation gene 3: a novel therapeutic target in chronic lymphocytic leukemia

Haematologica, 2017
A novel therapeutic approach in cancer, attempting to stimulate host anti-tumor immunity, involves blocking of immune checkpoints. Lymphocyte activation gene 3 (LAG3) is an immune checkpoint receptor expressed on activated/exhausted T cells. When engaged
M. Shapiro, Y. Herishanu, B. Katz, N. Dezorella, Clare Sun, S. Kay, A. Polliack, I. Avivi, A. Wiestner, C. Perry   +9 more
semanticscholar   +1 more source

Intimate Partner Violence is Associated with Increased CD4+ T-Cell Activation Among HIV-Negative High-Risk Women

Pathogens and Immunity, 2016
Background: Biological pathways mediating the link between intimate partner violence (IPV) and increased HIV risk remain unexplored. We hypothesized that IPV-induced stress negatively affects HIV systemic immune defenses and aimed to evaluate whether IPV
Ameeta Shivdas Kalokhe, Chris C. Ibegbu, Surinder P. Kaur, Rama R. Amara, Mary E. Kelley, Carlos del Rio, Rob Stephenson   +6 more
doaj   +1 more source

CD122-targeted interleukin-2 and αPD-L1 treat bladder cancer and melanoma via distinct mechanisms, including CD122-driven natural killer cell maturation

OncoImmunology, 2021
Bladder cancer (BC) and melanoma are amenable to immune checkpoint blockade (ICB) therapy, yet most patients with advanced/metastatic disease do not respond. CD122-targeted interleukin (IL)-2 can improve ICB efficacy, but mechanisms are unclear.
Ryan M Reyes, Chenghao Zhang, Yilun Deng, Niannian Ji, Neelam Mukherjee, Alvaro S Padron, Curtis A Clark, Robert S Svatek, Tyler J Curiel   +8 more
doaj   +1 more source

Isolation and Activation of Murine Lymphocytes [PDF]

Journal of Visualized Experiments, 2016
B and T cells, with their extremely diverse antigen-receptor repertoires, have the ability to mount specific immune responses against almost any invading pathogen1,2. Understandably, such intricate abilities are controlled by a large number of molecules involved in various cellular processes to ensure timely and spatially regulated immune responses3 ...
Lim, Jun Feng, Berger, Heidi, Su, I-hsin
openaire   +4 more sources

Lymphocyte Activation Gene 3 (LAG-3) Modulates the Ability of CD4 T-cells to Be Suppressed In Vivo

PLoS ONE, 2014
Lymphocyte Activation Gene – 3 (LAG-3) is an immune checkpoint molecule that regulates both T-cell activation and homeostasis. However, the molecular mechanisms underlying LAG-3’s function are generally unknown.
N. Durham, C. Nirschl, Christopher M. Jackson, Jimmy Elias, Christina M. Kochel, R. Anders, C. Drake   +6 more
semanticscholar   +1 more source

The M1 and M2 paradigm of macrophage activation: time for reassessment

F1000Prime Reports, 2014
Macrophages are endowed with a variety of receptors for lineage-determining growth factors, T helper (Th) cell cytokines, and B cell, host, and microbial products.
F. Martínez, S. Gordon
semanticscholar   +1 more source

Serum microRNAs as Biomarkers of Human Lymphocyte Activation in Health and Disease

Frontiers in Immunology, 2014
Induction of the adaptive immune system is evaluated mostly by assessment of serum antibody titers and T lymphocyte responses in peripheral blood, although T and B cell activation occurs in lymphoid tissues.
P. de Candia, A. Torri, M. Pagani, S. Abrignani   +3 more
semanticscholar   +1 more source

Activation and inhibition of lymphocytes by costimulation [PDF]

Journal of Clinical Investigation, 2002
Mounting an appropriate immune response depends on the careful regulation of lymphocyte activation. To this end, lymphocytes require two independent signals to become fully activated. The first, an antigen-specific signal is sent via the unique antigen receptor: T cell receptor (TCR) on T cells or surface Ig on B cells.
Kenneth A. Frauwirth, Craig B. Thompson
openaire   +3 more sources

The impact of adiposity on adipose tissue-resident lymphocyte activation in humans

International Journal of Obesity, 2014
Background/objectives:The presence of T lymphocytes in human adipose tissue has only recently been demonstrated and relatively little is known of their potential relevance in the development of obesity-related diseases.
Rebecca L Travers, A. C. Motta, J. Betts, A. Bouloumié, Dylan Thompson   +4 more
semanticscholar   +1 more source

A novel method to allow noninvasive, longitudinal imaging of the murine immune system in vivo [PDF]

, 2012
In vivo imaging has revolutionized understanding of the spatiotemporal complexity that subserves the generation of successful effector and regulatory immune responses.
Andrea J. White, Butcher, Cardillo, Carragher, Catherine M. Rush, Celli, de Boer, Eric J. Jenkinson, Farr, Fulmer, Gianluca Grassia, Girard, Graham Anderson, Gunn, Hillebrands, Huang, Iain B. McInnes, Itano, James M. Brewer, Karen J. Bryson, Kono, Lane, Leishman, Luther, McNagny, Millington, Pasquale Maffia, Paul Garside, Proudman, Robert A. Benson, Schneider, Smith, Stutzmann, Sumen, Tammela, Tomei, Vivienne B. Gibson, White, Worbs, Yoshida, Zinselmeyer   +40 more
core   +1 more source