Results 31 to 40 of about 34,914 (256)

Modifiable risk factors for cancer among people with lynch syndrome: an international, cross-sectional survey

Hereditary Cancer in Clinical Practice
Background Lynch syndrome is the most common cause of hereditary colorectal and endometrial cancer. Lifestyle modification may provide an opportunity for adjunctive cancer prevention.
Robert F. Power, Damien E. Doherty, Roberta Horgan, Pat Fahey, David J. Gallagher, Maeve A. Lowery, Karen A. Cadoo   +6 more
doaj   +1 more source

Molecular pathology of Lynch syndrome [PDF]

The Journal of Pathology, 2020
AbstractLynch syndrome (LS) is characterised by predisposition to colorectal, endometrial, and other cancers and is caused by inherited pathogenic variants affecting the DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6, and PMS2. It is probably the most common predisposition to cancer, having an estimated prevalence of between 1/100 and 1/180 ...
Guia Cerretelli, Ann Ager, Mark J Arends, Ian M Frayling   +3 more
openaire   +4 more sources

Association of a novel point mutation in MSH2 gene with familial multiple primary cancers

Journal of Hematology & Oncology, 2017
Background Multiple primary cancers (MPC) have been identified as two or more cancers without any subordinate relationship that occur either simultaneously or metachronously in the same or different organs of an individual. Lynch syndrome is an autosomal
Hai Hu, Hong Li, Feng Jiao, Ting Han, Meng Zhuo, Jiujie Cui, Yixue Li, Liwei Wang   +7 more
doaj   +1 more source

Comprehensive characterization of CRC with germline mutations reveals a distinct somatic mutational landscape and elevated cancer risk in the Chinese population

Cancer Biology & Medicine, 2022
Objective: Hereditary colorectal cancer (CRC) accounts for approximately 5%–10% of all CRC cases. The full profile of CRC-related germline mutations and the corresponding somatic mutational profile have not been fully determined in the Chinese population.
Jianfei Yao, Yunhuan Zhen, Jing Fan, Yuan Gong, Yumeng Ye, Shaohua Guo, Hongyi Liu, Xiaoyun Li, Guosheng Li, Pan Yang, Xiaohui Wang, Danni Liu, Tanxiao Huang, Huiya Cao, Peisu Suo, Yuemin Li, Jingbo Yu, Lele Song   +17 more
doaj   +1 more source

The diagnostic potential of urinary volatile organic compounds for colorectal neoplasia in Lynch syndrome-A prospective longitudinal study. [PDF]

Int J Cancer
What's new? Lynch syndrome demands lifelong colonoscopy surveillance to early detect and treat colorectal cancer (CRC) and prevent CRC by removing adenomas. However, colonoscopy overuse and post‐colonoscopy CRC rates among individuals with Lynch syndrome are problematic.
van Liere ELSA, Ramsoekh D, Stewart TK, Daulton E, Jacobs MAJM, Dekker E, Bosch S, Covington JA, de Meij TGJ, de Boer NKH.   +9 more
europepmc   +2 more sources

Monocyte maturation pattern by flow cytometry expression of CD64, CD300e, and CD14 correlates to presence of myeloid neoplasm and helps identify blast equivalents in the setting of monocytic neoplasm

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract CD300e is a marker of mature monocytes in flow cytometry; however, there is limited detailed information on staining patterns in conjunction with other monocyte markers. We evaluated the flow cytometric staining patterns of CD64, CD14, and CD300e in 12 negative and 33 positive peripheral blood specimens and 16 negative and 56 positive bone ...
Jenny Zhang, Jacob Kaplan, Elizabeth Courville   +2 more
wiley   +1 more source

Recent advances in Lynch syndrome

Experimental Hematology & Oncology, 2021
Lynch syndrome is one of the most common hereditary cancer syndromes and is characterized by the development of many cancers, such as colorectal cancer (CRC), endometrial cancer, ovarian cancer, stomach cancer and many other cancers.
Xi Li, Guodong Liu, Wei Wu
doaj   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Circulating metabolome landscape in Lynch syndrome

Cancer & Metabolism
Circulating metabolites systemically reflect cellular processes and can modulate the tissue microenvironment in complex ways, potentially impacting cancer initiation processes.
Tiina A. Jokela, Jari E. Karppinen, Minta Kärkkäinen, Jukka-Pekka Mecklin, Simon Walker, Toni T. Seppälä, Eija K. Laakkonen   +6 more
doaj   +1 more source

Improving genetic diagnosis of hereditary tumor syndromes: From expanded gene panels to functional genomics

International Journal of Cancer, EarlyView.
Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer, Morghan C. Lucas, Vitus Prokosch, Thomas Keßler, Thomas Risch, Andreas Laner, Jan Henkel, Anna Benet‐Pagès, Ariane Hallermayr, Verena Steinke‐Lange, Elke Holinski‐Feder, Barbara Klink   +11 more
wiley   +1 more source