Methods of Lysergic Acid Synthesis—The Key Ergot Alkaloid [PDF]
Molecules, 2022 Ergot is the spore form of the fungus Claviceps purpurea. Ergot alkaloids are indole compounds that are biosynthetically derived from L-tryptophan and represent the largest group of fungal nitrogen metabolites found in nature.
Michał K. Jastrzębski +2 more
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Construction of an efficient Claviceps paspali cell factory for lysergic acid production [PDF]
Frontiers in Bioengineering and Biotechnology, 2023 Lysergic acid (LA) is the key precursor of ergot alkaloids, and its derivatives have been used extensively for the treatment of neurological disorders. However, the poor fermentation efficiency limited its industrial application.
Mingzhe Hu +30 more
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Increasing lysergic acid levels for ergot alkaloid biosynthesis: Directing catalysis via the F-G loop of Clavine oxidases [PDF]
Frontiers in Microbiology, 2023 Most ergot alkaloid drugs are semi-synthetically derived from the natural product lysergic acid, a valuable precursor for the development of novel ergot alkaloid drugs.
Li Rong Lim +13 more
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Contribution of a novel gene to lysergic acid amide synthesis in Metarhizium brunneum [PDF]
BMC Research Notes, 2022 Objective The fungus Metarhizium brunneum produces ergot alkaloids of the lysergic acid amide class, most abundantly lysergic acid α-hydroxyethylamide (LAH). Genes for making ergot alkaloids are clustered in the genomes of producers. Gene clusters of LAH-
Kelcie N. Britton +4 more
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Reconstituting the complete biosynthesis of D-lysergic acid in yeast [PDF]
Nature Communications, 2022 The ergot alkaloids are a class of natural products known for their pharmacologically privileged molecular structure that are used in the treatment of neurological ailments.
Garrett Wong +6 more
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Lysergic Acid Diethylamide, Psilocybin and Dimethyltryptamine in Depression Treatment: A Systematic Review [PDF]
Pharmaceuticals, 2021 Despite many different kinds of substances available for depression treatment, depression itself still appears to be a clinical challenge. Recently, formerly illicit substances came to scientists’ attention, including lysergic acid diethylamide (LSD ...
Gniewko Więckiewicz +4 more
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Clinical Research on Lysergic Acid Diethylamide (LSD) in Psychiatry and Neuroscience [PDF]
PharmaceuticalsLysergic acid diethylamide (LSD) is gaining renewed interest as a potential treatment for anxiety, depression, and alcohol use disorder, with clinical trials reporting significant symptom reductions and long-lasting effects.
Hossein Omidian, Alborz Omidian
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Lysergic Acid Amide (LSA), an LSD Analog: Systematic Review of Pharmacological Effects, Adverse Outcomes, and Therapeutic Potentials [PDF]
PharmacyObjective: To systematically review the scientific literature on lysergic acid amide (LSA), focusing on its physical, neurobiological, and social effects, as well as its potential risks and therapeutic uses.
Paula S. C. C. Castro +7 more
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Quantification of Ergot Alkaloids via Lysergic Acid Hydrazide—Development and Comparison of a Sum Parameter Screening Method [PDF]
Molecules, 2023 Ergot alkaloids are a group of mycotoxins occurring in products derived from various grasses (e.g., rye) and have been regulated in the EU recently.
Maximilian Kuner +5 more
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Lysergic acid diethylamide (LSD) promotes social behaviour through 5-HT2A and ampa in the medial prefrontal cortex (MPFC) [PDF]
European Psychiatry, 2021 Introduction Autism Spectrum Disorder and Social Anxiety Disorder are mental illnesses characterized by a dysfunction in social behavior (SB); a phenomenon largely mediated by the medial prefrontal cortex (mPFC). Clinical studies have demonstrated that
A. Markopoulos +3 more
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