Lysergic Acid Diethylamide, Psilocybin and Dimethyltryptamine in Depression Treatment: A Systematic Review. [PDF]
Pharmaceuticals (Basel), 2021 Despite many different kinds of substances available for depression treatment, depression itself still appears to be a clinical challenge. Recently, formerly illicit substances came to scientists’ attention, including lysergic acid diethylamide (LSD ...
Więckiewicz G +4 more
europepmc +5 more sources
Methods of Lysergic Acid Synthesis-The Key Ergot Alkaloid. [PDF]
Molecules, 2022 Ergot is the spore form of the fungus Claviceps purpurea. Ergot alkaloids are indole compounds that are biosynthetically derived from L-tryptophan and represent the largest group of fungal nitrogen metabolites found in nature.
Jastrzębski MK, Kaczor AA, Wróbel TM.
europepmc +3 more sources
Reconstituting the complete biosynthesis of D-lysergic acid in yeast. [PDF]
Nat Commun, 2022 The ergot alkaloids are a class of natural products known for their pharmacologically privileged molecular structure that are used in the treatment of neurological ailments.
Wong G +6 more
europepmc +3 more sources
Contribution of a novel gene to lysergic acid amide synthesis in Metarhizium brunneum. [PDF]
BMC Res Notes, 2022 Objective The fungus Metarhizium brunneum produces ergot alkaloids of the lysergic acid amide class, most abundantly lysergic acid α-hydroxyethylamide (LAH). Genes for making ergot alkaloids are clustered in the genomes of producers. Gene clusters of LAH-
Britton KN +4 more
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Clinical Research on Lysergic Acid Diethylamide (LSD) in Psychiatry and Neuroscience. [PDF]
Pharmaceuticals (Basel)Lysergic acid diethylamide (LSD) is gaining renewed interest as a potential treatment for anxiety, depression, and alcohol use disorder, with clinical trials reporting significant symptom reductions and long-lasting effects.
Omidian H, Omidian A.
europepmc +3 more sources
Construction of an efficient Claviceps paspali cell factory for lysergic acid production. [PDF]
Front Bioeng Biotechnol, 2022 Lysergic acid (LA) is the key precursor of ergot alkaloids, and its derivatives have been used extensively for the treatment of neurological disorders. However, the poor fermentation efficiency limited its industrial application.
Hu M +9 more
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Increasing lysergic acid levels for ergot alkaloid biosynthesis: Directing catalysis via the F-G loop of Clavine oxidases. [PDF]
Front Microbiol, 2023 Most ergot alkaloid drugs are semi-synthetically derived from the natural product lysergic acid, a valuable precursor for the development of novel ergot alkaloid drugs.
Lim LR, Wong G, Go MK, Yew WS.
europepmc +2 more sources
Concerning the biogenesis of lysergic acid [PDF]
Experientia, 1954 Ein biogenetischer Weg zur Lysergsaure, bestehend in der Kondensation von Tryptophan mit Zitronensaure, wird vorgeschlagen.
N. L. Wendler
openaire +4 more sources
Quantification of Ergot Alkaloids via Lysergic Acid Hydrazide-Development and Comparison of a Sum Parameter Screening Method. [PDF]
Molecules, 2023 Ergot alkaloids are a group of mycotoxins occurring in products derived from various grasses (e.g., rye) and have been regulated in the EU recently.
Kuner M +5 more
europepmc +2 more sources
Total Synthesis of Lysergic Acid [PDF]
Organic Letters, 2013 A total synthesis of lysergic acid was accomplished. Key features of our synthesis include stereoselective construction of the stereogenic centers at the allylic positions by using the Evans aldol reaction, and a sequential process with a ring-closing metathesis and an intramolecular Heck reaction to construct the C and D rings.
Tohru Fukuyama +2 more
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