Results 91 to 100 of about 2,589 (171)

Lactylation in urological malignancies: emerging mechanisms and therapeutic direction

Frontiers in Cell and Developmental Biology
Urological malignancies represent a group of highly aggressive tumors with a strong tendency toward therapy resistance. Their pathogenesis is closely associated with metabolic reprogramming and epigenetic regulation. In recent years, lactylation, a novel
Jiafeng Lin, Chenye Yuan, Chunsheng Liu, Minjie Zhang, Jianbin Luo, Zhihuang Wu, Qinghong Ma, Shengbiao Xie, Yufeng Liang, Guoqiang Chen   +9 more
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Recapitulating hypoxic metabolism in cartilaginous organoids via adaptive cell-matrix interactions enhances histone lactylation and cartilage regeneration

Nature Communications
Mesenchymal condensation, characterized by rapid proliferation and aggregation of precursor cells within a restructured mesodermal extracellular matrix, is critical for skeletal tissue development, including articular cartilage.
Boguang Yang, Zhuo Li, Zhengmeng Yang, Pengchao Zhao, Sien Lin, Jiahao Wu, Wei Liu, Xuefeng Yang, Xian Xie, Zhixian Zong, Yuanning Lyu, Zhinan Yang, Gang Li, To Ngai, Kunyu Zhang, Liming Bian   +15 more
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Therapeutic potential of microglial SMEK1 in regulating H3K9 lactylation in cerebral ischemia-reperfusion

Communications Biology
Acute ischemic stroke (AIS) triggers immune responses and neuroinflammation, contributing to brain injury. Histone lactylation, a metabolic stress-related histone modification, plays a critical role in various diseases, but its involvement in cerebral ...
Wei-Yue Si, Chun-Lin Yang, Shu-Li Wei, Tong Du, Liang-Kang Li, Jing Dong, Yang Zhou, Heng Li, Peng Zhang, Qi-Ji Liu, Rui-Sheng Duan, Ruo-Nan Duan   +11 more
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Aldehyde Dehydrogenase 2 Lactylation Aggravates Mitochondrial Dysfunction by Disrupting PHB2 Mediated Mitophagy in Acute Kidney Injury

Advanced Science
Mitochondrial dysfunction is a crucial event in acute kidney injury (AKI), leading to a metabolic shift toward glycolysis and increased lactate production.
Jiaying Li, Xiaoxiao Shi, Jiatong Xu, Kaiyue Wang, Fangxing Hou, Xiaodong Luan, Limeng Chen   +6 more
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Histone Lactylation Couples FSH-Driven Lactate Metabolism to Mitochondrial Biogenesis by Enhancing HDAC4-Mediated Deacetylation of PGC-1α in Granulosa Cells

Research
Follicle-stimulating hormone (FSH) coordinates ovarian follicle development by aligning mitochondrial biogenesis with increased metabolic demand. Although FSH is known to stimulate glycolysis in granulosa cells (GCs), the mechanism by which glycolytic ...
Gang Wu, Min Chen, Chengyu Li, Mengli Wei, Yitong Pan, Tong He, Zhaojun Liu, Hongmin Li, Chunlei Zhang, Jia-Qing Zhang, Yanan Sheng, Yang Liu, Honglin Liu, Ming Shen   +13 more
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Appraising histone H4 lysine 5 lactylation as a novel biomarker in breast cancer

Scientific Reports
Background Posttranslational modifications of histone lysine (K) have integral connections with cell metabolism, and participate in the carcinogenesis of various cancers. This study focuses on evaluating the expression of histone H4 lys 5 lactylation (H4K5lac) and its clinical role in breast cancer (BC).
Ya Zhu, Yuping Fu, Fengzhen Liu, Sha Yan, Ruili Yu   +4 more
openaire   +3 more sources

Global profiling of protein lactylation in microglia in experimental high-altitude cerebral edema

Cell Communication and Signaling
Background High-altitude cerebral edema (HACE) is considered an end-stage acute mountain sickness (AMS) that typically occurs in people after rapid ascent to 2500 m or more.
Xiufang Jiang, Jiayue Gao, Xuechao Fei, Yanan Geng, Xiangpei Yue, Zibi Shi, Xiang Cheng, Tong Zhao, Ming Fan, Haitao Wu, Ming Zhao, Lingling Zhu   +11 more
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Lactylation of Mitochondrial Adenosine Triphosphate Synthase Subunit Alpha Regulates Vascular Remodeling and Progression of Aortic Dissection

Research
Aortic dissection (AD) is a cardiovascular disorder with a high mortality rate. Lysine Lactylation (Kla), a novel posttranslational modification, critically regulates inflammation, tumors, and cardiovascular diseases.
Tao Yu, Xiaolu Li, Chao Wang, Yanyan Yang, Xiuxiu Fu, Tianxiang Li, Wentao Wang, Xiangyu Liu, Xiaoxin Jiang, Ding Wei, Jian-Xun Wang   +10 more
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Lactate Dehydrogenase C4 Accelerates Triple‐Negative Breast Cancer Progression by Promoting Acetyl‐CoA Acyltransferase 2 Lactylation to Increase Free Fatty Acid Accumulation

Advanced Science
Lactate‐induced protein lysine (K) lactylation is inherently connected to cellular metabolism and is implicated in oncogenesis. As a crucial glycolytic enzyme in lactate metabolism, lactate dehydrogenase C4 (LDHC4) has undefined yet potentially ...
Zhaolei Cui, Chaoqiang Zheng, Yingying Lin, Zhenzhou Xiao, Yanhong Li, Wei Peng, Shijie He, Anyang Li, Xiufeng Wu, Yan Chen, Yang Sun   +10 more
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Protein lactylation in Alzheimer’s disease: bridging metabolism, pathology, and therapeutic opportunity

Frontiers in Aging Neuroscience
Lactate, long regarded as a mere by-product of glycolysis, is increasingly recognized as a signaling metabolite and epigenetic regulator through protein lactylation.
Huawen Cao, Junyi Liang, Xiaohong Dong, Zhiqi Xia, Xiaoting Luo, Bin Liu   +5 more
doaj   +1 more source