Results 91 to 100 of about 4,831 (203)

Improving protein succinylation sites prediction using embeddings from protein language model [PDF]

, 2022
Protein succinylation is an important post-translational modification (PTM) responsible for many vital metabolic activities in cells, including cellular respiration, regulation, and repair.
Heinzinger, Michael, KC, Dukka, Newman, Robert H., Pokharel, Suresh, Pratyush, Pawel   +4 more
core   +3 more sources

SIRT5–RAC2 Axis Drives Monocyte‐to‐Macrophage Differentiation to Promote Inflammatory Injury in Premature Ovarian Insufficiency

Advanced Science, Volume 13, Issue 14, 9 March 2026.
SIRT5 desuccinylates and stabilizes RAC2, activating CSF1R‐dependent signaling to drive monocyte differentiation into M0 macrophages and their polarization toward pro‐inflammatory M1 phenotypes in CTX‐induced premature ovarian insufficiency. Inhibiting the SIRT5‐RAC2 axis attenuates inflammation, reduces granulosa cell apoptosis, and preserves ...
Wenjing TanTai, Yaqi Li, Shengnan Liu, Minjuan Wu, Zhixiao Liu, Junfeng Jiang, Jingjing Chen, Xiaoding Xu, Li Li, Chaoqun Li, Fang Zhao, Ye Liu, Haitao Ni, Tengfei Zhang, Mingjuan Xu, Chaofeng Han   +15 more
wiley   +1 more source

Epigenomic regulation of heart failure: integrating histone marks, long noncoding RNAs, and chromatin architecture. [PDF]

, 2018
Epigenetic processes are known to have powerful roles in organ development across biology. It has recently been found that some of the chromatin modulatory machinery essential for proper development plays a previously unappreciated role in the ...
McKinsey, Timothy A, Vondriska, Thomas M, Wang, Yibin   +2 more
core  

HAMAP in 2015: updates to the protein family classification and annotation system. [PDF]

, 2015
HAMAP (High-quality Automated and Manual Annotation of Proteins-available at http://hamap.expasy.org/) is a system for the automatic classification and annotation of protein sequences. HAMAP provides annotation of the same quality and detail as UniProtKB/
Auchincloss, A.H., Baratin, D., Bougueleret, L., Bridge, A., Coudert, E., Cuche, B.A., de Castro, E., Keller, G., Pedruzzi, I., Poux, S., Redaschi, N., Rivoire, C., Xenarios, I.   +12 more
core   +1 more source

Understanding protein–flavor interactions: Factors, characterization techniques, and the effect of processing

Food Biomacromolecules, Volume 3, Issue 1, Page 47-70, March 2026.
Abstract The perception of flavor in a food system depends on its release from the protein matrix. Apart from hydrogen bonding, hydrophobic interactions and van der Waal's forces, the formation of covalent adducts between the flavor and protein highly impacts the release of flavor from the protein matrix.
Arshita Verma, Somnath Basak, Rekha S. Singhal   +2 more
wiley   +1 more source

Epigenomes in Cardiovascular Disease. [PDF]

, 2018
If unifying principles could be revealed for how the same genome encodes different eukaryotic cells and for how genetic variability and environmental input are integrated to impact cardiovascular health, grand challenges in basic cell biology and ...
McKinsey TA, Morimoto T, Poller W, Turner BM, Wang Y   +4 more
core   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, Volume 12, Issue 1, Page 65-85, Spring 2026.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

A Versatile Approach for Siteâ Specific Lysine Acylation in Proteins [PDF]

, 2017
Using amber suppression in coordination with a mutant pyrrolysylâ tRNA synthetaseâ tRNAPyl pair, azidonorleucine is genetically encoded in E. coli. Its genetic incorporation followed by traceless Staudinger ligation with a phosphinothioester allows the
Dai, Susie Y., Kurra, Yadagiri, Lee, Yan‐jiun, Lin, Hening, Liu, Wenshe R., Sharma, Vangmayee, Wang, Xin, Wang, Zhipeng A., Zeng, Yu   +8 more
core   +1 more source

Recent Developments and Applications of Capillary and Microchip Electrophoresis in Proteomics and Peptidomics (2023–2025)

Journal of Separation Science, Volume 49, Issue 3, March 2026.
ABSTRACT This review article presents a broad overview of developments and applications of capillary electrophoresis (CE) and microchip electrophoresis (MCE) in peptidomics and proteomics in the period 2023–2025. It deals with various methodological aspects, such as sample preparation including preseparation and preconcentration, multidimensional ...
Sille Štěpánová, Václav Kašička
wiley   +1 more source

Quantification of Site-specific Protein Lysine Acetylation and Succinylation Stoichiometry Using Data-independent Acquisition Mass Spectrometry. [PDF]

, 2018
Post-translational modification (PTM) of protein lysine residues by NƐ-acylation induces structural changes that can dynamically regulate protein functions, for example, by changing enzymatic activity or by mediating interactions.
Meyer, Jesse, Schilling, Birgit, Wei, Lei   +2 more
core   +1 more source