Results 31 to 40 of about 10,942 (204)

Shedding new light on lipid biology with coherent anti-Stokes Raman scattering microscopy

open access: yesJournal of Lipid Research, 2010
Despite the ubiquitous roles of lipids in biology, the detection of lipids has relied on invasive techniques, population measurements, or nonspecific labeling. Such difficulties can be circumvented by a label-free imaging technique known as coherent anti-
Thuc T. Le, Shuhua Yue, Ji-Xin Cheng
doaj   +1 more source

A Review of Cyclic Phosphatidic Acid and Other Potential Therapeutic Targets for Treating Osteoarthritis

open access: yesBiomedicines, 2023
Osteoarthritis (OA), a chronic degenerative joint disease, is the most common form of arthritis. OA occurs when the protective cartilage that cushions the ends of bones gradually breaks down.
Tamotsu Tsukahara   +2 more
doaj   +1 more source

Dietary Supplementation of Lysophospholipids Affects Feed Digestion in Lambs

open access: yesAnimals, 2019
Five experiments were conducted to examine effects of lysophospholipids (LPL) on live weight gain, nutrient digestibility, ruminal fermentation parameters, serum biochemical parameters and rumen bacterial community profile in fattening lambs. Two dietary
Qin Huo   +14 more
doaj   +1 more source

Current Knowledge on Mammalian Phospholipase A1, Brief History, Structures, Biochemical and Pathophysiological Roles

open access: yesMolecules, 2022
Phospholipase A1 (PLA1) is an enzyme that cleaves an ester bond at the sn-1 position of glycerophospholipids, producing a free fatty acid and a lysophospholipid.
Shun Yaginuma   +2 more
doaj   +1 more source

Lysophospholipid receptors: Signalling, pharmacology and regulation by lysophospholipid metabolism

open access: yesBiochimica et Biophysica Acta (BBA) - Biomembranes, 2007
The lysophospholipids, sphingosine-1-phosphate (S1P), lysophosphatidic acid (LPA), sphingosylphosphorylcholine (SPC) and lysophosphatidylcholine (LPC), activate diverse groups of G-protein-coupled receptors that are widely expressed and regulate decisive cellular functions.
Meyer zu Heringdorf, Dagmar   +1 more
openaire   +2 more sources

Lysophospholipid mediators in the vasculature [PDF]

open access: yesExperimental Cell Research, 2015
Acting through cell surface receptors, “extracellular” lysophosphatidic acid (LPA) influences cell growth, differentiation, apoptosis and development in a wide spectrum of settings [1–5]. Within the vasculature, smooth muscle cells [6, 7], endothelial cells [8] and platelets [9, 10] display notable responses to LPA [11, 12], which likely regulate blood
Paul Mueller   +3 more
openaire   +2 more sources

Upregulation of ABC transporters contributes to chemoresistance of sphingosine 1-phosphate lyase-deficient fibroblasts

open access: yesJournal of Lipid Research, 2015
Sphingosine 1-phosphate (S1P) is an extra- and intracellular mediator that regulates cell growth, survival, migration, and adhesion in many cell types.
Katja Ihlefeld   +9 more
doaj   +1 more source

Daily rhythms of glycerophospholipid synthesis in fibroblast cultures involve differential enzyme contributions [PDF]

open access: yes, 2013
Circadian clocks regulate the temporal organization of several biochemical processes including lipid metabolism and their disruption leads to severe metabolic disorders. Immortalized cell lines acting as circadian clocks display daily variations in [32P]-
Acosta Rodríguez, Victoria América   +7 more
core   +2 more sources

Lysophospholipids in laboratory medicine

open access: yesProceedings of the Japan Academy, Series B, 2018
Lysophospholipids (LPLs), such as lysophosphatidic acid (LPA), sphingosine 1-phosphate (S1P), and lysophosphatidylserine (LysoPS), are attracting attention as second-generation lipid mediators. In our laboratory, the functional roles of these lipid mediators and the mechanisms by which the levels of these mediators are regulated in vivo have been ...
YATOMI, Yutaka   +5 more
openaire   +3 more sources

Peroxisome Proliferators Attenuate Free Arachidonic Acid Pool in the Kidney Through Inducing Lysophospholipid Acyltransferases

open access: yesJournal of Pharmacological Sciences, 2009
Attenuating effects of peroxisome proliferators on the concentration of free arachidonic acid by inducing 1-acyl-2-lysophospholipid acyltransferases in the kidney were studied.
Tohru Yamazaki   +6 more
doaj   +1 more source

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